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- W2052688891 abstract "Disorders of the central nervous system (CNS), including stroke, neurodegenerative diseases, and brain tumors, are the world’s leading causes of disability. Delivery of drugs to the CNS is complicated by the blood–brain barriers that protect the brain from the unregulated leakage and entry of substances, including proteins, from the blood. Yet proteins represent one of the most promising classes of therapeutics for the treatment of CNS diseases. Many strategies for overcoming these obstacles are in development, but the relatively straightforward approach of bypassing these barriers through direct intrathecal administration has been largely overlooked. Originally discounted because of its lack of usefulness for delivering small, lipid-soluble drugs to the brain, the intrathecal route has emerged as a useful, in some cases perhaps the ideal, route of administration for certain therapeutic protein and targeted disease combinations. Here, we review blood–brain barrier functions and cerebrospinal fluid dynamics and their relevance to drug delivery via the intrathecal route, discuss animal and human studies that have investigated intrathecal delivery of protein therapeutics, and outline several characteristics of protein therapeutics that can allow them to be successfully delivered intrathecally." @default.
- W2052688891 created "2016-06-24" @default.
- W2052688891 creator A5000007928 @default.
- W2052688891 creator A5010997422 @default.
- W2052688891 creator A5022496894 @default.
- W2052688891 creator A5054959155 @default.
- W2052688891 creator A5071494174 @default.
- W2052688891 date "2014-11-01" @default.
- W2052688891 modified "2023-10-11" @default.
- W2052688891 title "Intrathecal delivery of protein therapeutics to the brain: A critical reassessment" @default.
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