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- W2052717304 abstract "Abstract An average chlorhexidine concentration of 4·5 μg mg−1 lens (wet weight) was measured in HEMA-based contact lenses after 16 days of the following treatment. The lenses were maintained 16 h daily in 1·5 ml of a solution containing Chlorhexidine digluconate 0·005%, and then worn by adult albino rabbits 8 h daily. Similarly maintained, but unworn lenses contained approximately 23 μg Chlorhexidine mg−1 wet lens weight after 16 days. A plot of the results indicates that continued exposure to Chlorhexidine following initial immersion increased its concentration in unworn lenses while that in the worn lenses reached a peak at 8 days, then decreased slightly in the subsequent days of wearing. Continuous exposure of lenses to the disinfecting solution (1 lens/167 ml) in which the Chlorhexidine concentration was maintained at 0005% for 16 days gave a maximal concentration of 44 μg mg−1 wet lens weight. The comparatively small concentration in a worn lens results from: (1) daily loss from the lens during wear, a large percentage of which is apparently absorbed to tear proteins which subsequently flow from the eyes via the canaliculi; (2) limited uptake because of the small immersion volume employed in routine storage; and (3) the possible competition between Chlorhexidine and tear components for lens binding sites or establishment of an equilibrium condition between uptake and release." @default.
- W2052717304 created "2016-06-24" @default.
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- W2052717304 date "1978-09-01" @default.
- W2052717304 modified "2023-09-27" @default.
- W2052717304 title "Chlorhexidine kinetics of hydrophilic contact lenses" @default.
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- W2052717304 doi "https://doi.org/10.1111/j.2042-7158.1978.tb13363.x" @default.
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