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• W2052719913 abstract "Some atypical antipsychotic drugs appear to improve cognitive function in schizophrenia and since acetylcholine (ACh) is of importance in cognition, we used in vivo microdialysis to examine the effects of antipsychotics administered acutely (SC or IP) at pharmacologically comparable doses on ACh outflow in the hippocampus of the rat. The atypical antipsychotics olanzapine and clozapine produced robust increases in ACh up to 1500% and 500%, respectively. The neuroleptics haloperidol, thioridazine, and chlorpromazine, as well as the atypical antipsychotics risperidone and ziprasidone produced modest increases in ACh by about 50–100%. Since most atypical antipsychotics affect a variety of monoaminergic receptors, we examined whether selective ligands for some of these receptors affect hippocampal ACh. Antagonists for the 5-HT2A (MDL 100,907), the 5-HT2C (SB 242,084), the 5-HT6 (Ro 04-6790), the D2 (raclopride) receptors, and the α1-adrenoceptors (prazosin) modestly increased ACh by about 50%. The 5-HT1A agonist R-(+)-8-OH-DPAT and the α2-adrenoceptor antagonist yohimbine significantly increased ACh by about 100% and 50%, respectively. Thus, olanzapine and clozapine increased ACh to a greater extent than other tested antipsychotics, explaining perhaps their purported beneficial effect in cognitive function in schizophrenia. It appears that selective activity at each of the monoaminergic receptors studied is not the sole mechanism underlying the olanzapine and clozapine induced increases in hippocampal ACh." @default.
• W2052719913 created "2016-06-24" @default.
• W2052719913 creator A5015736205 @default.
• W2052719913 date "2002-05-01" @default.
• W2052719913 modified "2023-10-17" @default.
• W2052719913 title "Effects of Typical and Atypical Antipsychotics and Receptor Selective Compounds on Acetylcholine Efflux in the Hippocampus of the Rat" @default.
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• W2052719913 doi "https://doi.org/10.1016/s0893-133x(01)00400-6" @default.
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