Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052725315> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2052725315 endingPage "481" @default.
- W2052725315 startingPage "481" @default.
- W2052725315 abstract "The existence of links between Alzheimer's disease and diabetes is an important topic currently under active debate. Establishing such links if they exist and defining their common pathogenesis and pathophysiological mechanisms may lead to new concepts and research directions for the pharmacological treatment of Alzheimer's disease and diabetes. Alzheimer's disease is associated with peripheral and central insulin abnormalities. Cognitive capacities are often impaired in patients with diabetes. There are many mechanisms by which insulin-signaling abnormalities may affect clinical and pathological outcome of Alzheimer's disease. Insulin resistance and dysregulation of the degradation of neurotoxic amyloid and insulin appear at the core of the links between Alzheimer's disease and diabetes. Functions and expression of insulysin, an enzyme involved in the degradation of neurotoxic amyloid peptides and insulin, are usually impaired or reduced in Alzheimer's disease and diabetes. The increased occurrence of insulin resistance in Alzheimer's disease suggests that improving insulin effectiveness and insulysin activity may have therapeutic value in Alzheimer's disease patients and therefore is worth intensive investigation." @default.
- W2052725315 created "2016-06-24" @default.
- W2052725315 creator A5064940970 @default.
- W2052725315 creator A5072355639 @default.
- W2052725315 date "2006-01-01" @default.
- W2052725315 modified "2023-10-16" @default.
- W2052725315 title "Links between Alzheimer's disease and diabetes" @default.
- W2052725315 doi "https://doi.org/10.1358/dot.2006.42.7.973588" @default.
- W2052725315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17066144" @default.
- W2052725315 hasPublicationYear "2006" @default.
- W2052725315 type Work @default.
- W2052725315 sameAs 2052725315 @default.
- W2052725315 citedByCount "50" @default.
- W2052725315 countsByYear W20527253152012 @default.
- W2052725315 countsByYear W20527253152013 @default.
- W2052725315 countsByYear W20527253152014 @default.
- W2052725315 countsByYear W20527253152015 @default.
- W2052725315 countsByYear W20527253152016 @default.
- W2052725315 countsByYear W20527253152017 @default.
- W2052725315 countsByYear W20527253152018 @default.
- W2052725315 countsByYear W20527253152019 @default.
- W2052725315 countsByYear W20527253152020 @default.
- W2052725315 countsByYear W20527253152022 @default.
- W2052725315 countsByYear W20527253152023 @default.
- W2052725315 crossrefType "journal-article" @default.
- W2052725315 hasAuthorship W2052725315A5064940970 @default.
- W2052725315 hasAuthorship W2052725315A5072355639 @default.
- W2052725315 hasConcept C126322002 @default.
- W2052725315 hasConcept C134018914 @default.
- W2052725315 hasConcept C142724271 @default.
- W2052725315 hasConcept C15744967 @default.
- W2052725315 hasConcept C169760540 @default.
- W2052725315 hasConcept C2777180221 @default.
- W2052725315 hasConcept C2777391703 @default.
- W2052725315 hasConcept C2777633098 @default.
- W2052725315 hasConcept C2779134260 @default.
- W2052725315 hasConcept C2779306644 @default.
- W2052725315 hasConcept C2780331951 @default.
- W2052725315 hasConcept C2780942790 @default.
- W2052725315 hasConcept C502032728 @default.
- W2052725315 hasConcept C555293320 @default.
- W2052725315 hasConcept C60644358 @default.
- W2052725315 hasConcept C71924100 @default.
- W2052725315 hasConcept C86803240 @default.
- W2052725315 hasConceptScore W2052725315C126322002 @default.
- W2052725315 hasConceptScore W2052725315C134018914 @default.
- W2052725315 hasConceptScore W2052725315C142724271 @default.
- W2052725315 hasConceptScore W2052725315C15744967 @default.
- W2052725315 hasConceptScore W2052725315C169760540 @default.
- W2052725315 hasConceptScore W2052725315C2777180221 @default.
- W2052725315 hasConceptScore W2052725315C2777391703 @default.
- W2052725315 hasConceptScore W2052725315C2777633098 @default.
- W2052725315 hasConceptScore W2052725315C2779134260 @default.
- W2052725315 hasConceptScore W2052725315C2779306644 @default.
- W2052725315 hasConceptScore W2052725315C2780331951 @default.
- W2052725315 hasConceptScore W2052725315C2780942790 @default.
- W2052725315 hasConceptScore W2052725315C502032728 @default.
- W2052725315 hasConceptScore W2052725315C555293320 @default.
- W2052725315 hasConceptScore W2052725315C60644358 @default.
- W2052725315 hasConceptScore W2052725315C71924100 @default.
- W2052725315 hasConceptScore W2052725315C86803240 @default.
- W2052725315 hasIssue "7" @default.
- W2052725315 hasLocation W20527253151 @default.
- W2052725315 hasLocation W20527253152 @default.
- W2052725315 hasOpenAccess W2052725315 @default.
- W2052725315 hasPrimaryLocation W20527253151 @default.
- W2052725315 hasRelatedWork W1994331035 @default.
- W2052725315 hasRelatedWork W2029427029 @default.
- W2052725315 hasRelatedWork W2053684471 @default.
- W2052725315 hasRelatedWork W2067146874 @default.
- W2052725315 hasRelatedWork W2109371472 @default.
- W2052725315 hasRelatedWork W2165176013 @default.
- W2052725315 hasRelatedWork W2242448821 @default.
- W2052725315 hasRelatedWork W3186378505 @default.
- W2052725315 hasRelatedWork W4245156471 @default.
- W2052725315 hasRelatedWork W4385326275 @default.
- W2052725315 hasVolume "42" @default.
- W2052725315 isParatext "false" @default.
- W2052725315 isRetracted "false" @default.
- W2052725315 magId "2052725315" @default.
- W2052725315 workType "article" @default.