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- W2052743019 abstract "It is my purpose in this paper to present two new pedigrees which lend support to evidence that retinoblastoma is a hereditary form of neoplasia. An increased interest in the genetic determination of such tumors has been evidenced in the medical literature of recent years. Weller1in 1941, Griffith and Sorsby2in 1944 and Rados3in 1946 carefully reviewed and analyzed the evidence that such malignant neoplasms of childhood may be the results of hereditary factors. Weller cautiously concluded that there is no clearcut evidence to demonstrate that the predisposition to retinoblastoma behaves either as a simple dominant or as a simple recessive trait. This author postulates an inheritance of a somatic variation, possibly a structural anomaly, on which retinoblastoma may or may not develop. It was further suggested that retinoblastoma may belong to those congenital new growths which have been termed the phakomatoses. Griffith and Sorsby" @default.
- W2052743019 created "2016-06-24" @default.
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- W2052743019 date "1947-01-18" @default.
- W2052743019 modified "2023-09-25" @default.
- W2052743019 title "INHERITANCE OF RETINOBLASTOMA" @default.
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- W2052743019 doi "https://doi.org/10.1001/jama.1947.02880030025005" @default.
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