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- W2052747176 abstract "A reduction in recombination in the pseudoautosomal region is associated with an increased frequency of aneuploid 24,XY human sperm. Similarly, individuals with paternally derived Klinefelter syndrome (47,XXY) also have a paucity of recombination in the chromosomes that have undergone nondisjunction. Meiotic studies using newly developed immunocytogenetic techniques have demonstrated errors of chromosome synapsis and significantly reduced recombination in infertile men with nonobstructive azoospermia. These men have an increased risk of aneuploidy in sperm that have been surgically removed from the testes. Thus, evidence is starting to accumulate that reduced recombination has a marked effect on the generation of aneuploid sperm." @default.
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- W2052747176 date "2005-01-01" @default.
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- W2052747176 title "Mechanisms of nondisjunction in human spermatogenesis" @default.
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- W2052747176 doi "https://doi.org/10.1159/000086895" @default.
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