Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052801132> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2052801132 endingPage "9" @default.
- W2052801132 startingPage "1" @default.
- W2052801132 abstract "Abstract The applicability of poly(DL‐lactide‐co‐ϵ‐caprolactone) copolymers P(DL‐LA/CL) for controlled‐release devices was evaluated. The copolymers of DL‐lactide and ϵ‐caprolactone were polymerized in bulk using Sn(II)octoate as the initiator. The release of three model compounds, theophylline, propranolol hydrochloride, and lidocaine (10 wt%), from high‐lactide content copolymer was studied. The results showed that the copolymer with only minor caprolactone content was not suitable for controlled release of these small‐molecular weight model compounds in matrix‐type devices. A burst in the release rate was observed when the degradation of the matrix replaced diffusion‐controlled release. Increasing the permeation properties of the copolymer matrix through blending and using a different comonomer ratio with an increased caprolactone content were both studied. A release that was more controlled but relatively slow was obtained by using copolyester blends as release matrices. Hydrolytic degradation of the copolymers was also recorded, and the copolymers were found to be very susceptible to hydrolytic chain scission at 37°C. Molecular modeling studies were performed to study the interactions between the theophylline model compound and the homo‐ and copolymers of lactide and ε‐caprolactone units. In agreement with experimental results, the calculations showed increasing interaction between theophylline and the polymer matrix as a function of increasing amount of lactide units. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1–9, 2002" @default.
- W2052801132 created "2016-06-24" @default.
- W2052801132 creator A5012756411 @default.
- W2052801132 creator A5030448812 @default.
- W2052801132 creator A5063667596 @default.
- W2052801132 creator A5071999837 @default.
- W2052801132 date "2002-07-22" @default.
- W2052801132 modified "2023-10-18" @default.
- W2052801132 title "Model compound release from DL-lactide/ε-caprolactone copolymers and evaluation of specific interactions by molecular modeling" @default.
- W2052801132 cites W106251639 @default.
- W2052801132 cites W1969594568 @default.
- W2052801132 cites W1975117977 @default.
- W2052801132 cites W1983473009 @default.
- W2052801132 cites W1988719065 @default.
- W2052801132 cites W1997037235 @default.
- W2052801132 cites W2011805684 @default.
- W2052801132 cites W2020529817 @default.
- W2052801132 cites W2024312760 @default.
- W2052801132 cites W2049104590 @default.
- W2052801132 cites W2071699948 @default.
- W2052801132 cites W2073233871 @default.
- W2052801132 cites W2080484825 @default.
- W2052801132 cites W2103680379 @default.
- W2052801132 cites W2616466876 @default.
- W2052801132 doi "https://doi.org/10.1002/app.10443" @default.
- W2052801132 hasPublicationYear "2002" @default.
- W2052801132 type Work @default.
- W2052801132 sameAs 2052801132 @default.
- W2052801132 citedByCount "12" @default.
- W2052801132 countsByYear W20528011322012 @default.
- W2052801132 countsByYear W20528011322013 @default.
- W2052801132 crossrefType "journal-article" @default.
- W2052801132 hasAuthorship W2052801132A5012756411 @default.
- W2052801132 hasAuthorship W2052801132A5030448812 @default.
- W2052801132 hasAuthorship W2052801132A5063667596 @default.
- W2052801132 hasAuthorship W2052801132A5071999837 @default.
- W2052801132 hasConcept C15920480 @default.
- W2052801132 hasConcept C159985019 @default.
- W2052801132 hasConcept C188027245 @default.
- W2052801132 hasConcept C192562407 @default.
- W2052801132 hasConcept C203897987 @default.
- W2052801132 hasConcept C2776743539 @default.
- W2052801132 hasConcept C2779868350 @default.
- W2052801132 hasConcept C2780672802 @default.
- W2052801132 hasConcept C2781111393 @default.
- W2052801132 hasConcept C44228677 @default.
- W2052801132 hasConcept C521977710 @default.
- W2052801132 hasConceptScore W2052801132C15920480 @default.
- W2052801132 hasConceptScore W2052801132C159985019 @default.
- W2052801132 hasConceptScore W2052801132C188027245 @default.
- W2052801132 hasConceptScore W2052801132C192562407 @default.
- W2052801132 hasConceptScore W2052801132C203897987 @default.
- W2052801132 hasConceptScore W2052801132C2776743539 @default.
- W2052801132 hasConceptScore W2052801132C2779868350 @default.
- W2052801132 hasConceptScore W2052801132C2780672802 @default.
- W2052801132 hasConceptScore W2052801132C2781111393 @default.
- W2052801132 hasConceptScore W2052801132C44228677 @default.
- W2052801132 hasConceptScore W2052801132C521977710 @default.
- W2052801132 hasIssue "1" @default.
- W2052801132 hasLocation W20528011321 @default.
- W2052801132 hasOpenAccess W2052801132 @default.
- W2052801132 hasPrimaryLocation W20528011321 @default.
- W2052801132 hasRelatedWork W1990072825 @default.
- W2052801132 hasRelatedWork W1999164141 @default.
- W2052801132 hasRelatedWork W2066330701 @default.
- W2052801132 hasRelatedWork W2078046810 @default.
- W2052801132 hasRelatedWork W2289995744 @default.
- W2052801132 hasRelatedWork W2325827329 @default.
- W2052801132 hasRelatedWork W2349032814 @default.
- W2052801132 hasRelatedWork W2356526829 @default.
- W2052801132 hasRelatedWork W3041247771 @default.
- W2052801132 hasRelatedWork W4280501618 @default.
- W2052801132 hasVolume "86" @default.
- W2052801132 isParatext "false" @default.
- W2052801132 isRetracted "false" @default.
- W2052801132 magId "2052801132" @default.
- W2052801132 workType "article" @default.