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• W2052802018 abstract "Abstract Quantification of short‐echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previously experimentally achieved by exploiting the several fold difference in T 1 . To minimize effects of heterogeneities in metabolites T 1 , the aim of the study was to assess MM signal contributions by combining inversion recovery (IR) and diffusion‐weighted proton spectroscopy at high‐magnetic field (14.1 T) and short echo time (=8 msec) in the rat brain. IR combined with diffusion weighting experiments (with δ/Δ = 1.5/200 msec and b ‐value = 11.8 msec/μm 2 ) showed that the metabolite nulled spectrum (inversion time = 740 msec) was affected by residuals attributed to creatine, inositol, taurine, choline, N ‐acetylaspartate as well as glutamine and glutamate. While the metabolite residuals were significantly attenuated by 50%, the MM signals were almost not affected (<8%). The combination of metabolite‐nulled IR spectra with diffusion weighting allows a specific characterization of MM resonances with minimal metabolite signal contributions and is expected to lead to a more precise quantification of the neurochemical profile. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc." @default.
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• W2052802018 date "2010-06-17" @default.
• W2052802018 modified "2023-10-12" @default.
• W2052802018 title "Diffusion-weighted spectroscopy: A novel approach to determine macromolecule resonances in short-echo time 1H-MRS" @default.
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• W2052802018 doi "https://doi.org/10.1002/mrm.22490" @default.
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