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• W2052802581 abstract "ABSTRACT Alcelaphine herpesvirus 1 (AlHV-1), carried by wildebeest asymptomatically, causes malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. Experimentally, WD-MCF can be reproduced in rabbits. WD-MCF is described as a combination of lymphoproliferation and degenerative lesions in virtually all organs and is caused by unknown mechanisms. Recently, we demonstrated that WD-MCF is associated with the proliferation of CD8 + cells supporting a latent type of infection in lymphoid tissues. Here, we investigated the macroscopic distribution of AlHV-1 infection using ex vivo bioluminescence imaging in rabbit to determine whether it correlates with the distribution of lesions in lymphoid and nonlymphoid organs. To reach that goal, a recombinant AlHV-1 strain was produced by insertion of a luciferase expression cassette ( luc ) in an intergenic region. In vitro , the reconstituted AlHV-1 luc + strain replicated comparably to the parental strain, and luciferase activity was detected by bioluminescence imaging. In vivo , rabbits infected with the AlHV-1 luc + strain developed WD-MCF comparably to rabbits infected with the parental wild-type strain, with hyperthermia and increases of both CD8 + T cell frequencies and viral genomic charge over time in peripheral blood mononuclear cells and in lymph nodes at time of euthanasia. Bioluminescent imaging revealed that AlHV-1 infection could be detected ex vivo in lymphoid organs but also in lung, liver, and kidney during WD-MCF, demonstrating that AlHV-1 infection is prevalent in tissue lesions. Finally, we show that the infiltrating mononuclear leukocytes in nonlymphoid organs are mainly CD8 + T cells and that latency is predominant during WD-MCF." @default.
• W2052802581 created "2016-06-24" @default.
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• W2052802581 date "2011-07-15" @default.
• W2052802581 modified "2023-10-16" @default.
• W2052802581 title "<i>Ex Vivo</i> Bioluminescence Detection of Alcelaphine Herpesvirus 1 Infection during Malignant Catarrhal Fever" @default.
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• W2052802581 doi "https://doi.org/10.1128/jvi.00286-11" @default.
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