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• W2052803922 abstract "Recently, there has been a growing awareness of creatine kinase (CK) electrophoretic bands which exhibit mobilities different from those of CK-MM, MB and BB. These electrophoretic bands have been designated as “variant”, “atypical”, or “macro-CK” isoenzymes, and their mobilities can be cathodic or anodic [l-5]. Anodic variants have been found between the origin and CK-MM and also between CK-MM and CK-MB bands. Their formation has been variously attributed to polymeric aggregation of CK monomers, or to complexing of CK isoenzymes with immunoglobulins, lipids, lipoproteins, or unknown serum components. Cathodic variant bands, on the other hand, have generally been assumed to be of mitochondrial origin [6,7]. These variant isoenzymes are of both practical and clinical interest to laboratory scientists and physicians. A number of reports have already appeared dealing with their origin and possible clinical significance. In this brief review, we propose to examine critically the generally adopted procedures for characterization of variant CK isoenzymes and some of the assumptions underlying their clinical interpretation. Variant CK isoenzymes are commonly detected by electrophoresis and initially defined as such by their unusual electrophoretic mobilities compared to those of CK-MM, MB and BB isoenzymes. Immunochemical techniques have been used to characterize further the components of the variant bandsimmunoinhibition assays using anti-CK-M and anti-CK-B antisera to determine if the variant isoenzymes have CK-M or CK-B immunoreactivity [2,3,5] and immunoprecipitation techniques with antisera of different specificities (e.g., antiserum against IgG) to identify the unknown complexing substance [2,3,8]. In addition, tests based on physical properties, e.g., stability to heat treatment and urea dissociation, molecular size by gel permeation chromatography, are frequently used. Although more sophisticated techniques, e.g., ion exchange chromatography [ 1,9], isoelectric focusing [ 10,111, and gel filtration chromatography [ 12,131 can also detect variant isoenzymes, those techniques are not used routinely in clinical laboratories, and have not been responsible for the initial detection of most of the reported cases of variant CK isoenzymes. For this reason, we chose to restrict our discussion to the" @default.
• W2052803922 created "2016-06-24" @default.
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• W2052803922 date "1981-08-01" @default.
• W2052803922 modified "2023-09-23" @default.
• W2052803922 title "How many creatine kinase “isoenzymes” are there and what is their clinical significance?" @default.
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• W2052803922 doi "https://doi.org/10.1016/0009-8981(81)90102-9" @default.
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