FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052804020> ?p ?o ?g. }

• W2052804020 endingPage "1873" @default.
• W2052804020 startingPage "1865" @default.
• W2052804020 abstract "The aim of the present study was to evaluate the potential of PEGylated solid lipid nanoparticle (pSLN) as mucus penetrating particles (MPP) for oral delivery across gastrointestinal mucus. The SLN was prepared by an aqueous solvent diffusion method, subsequently modified with PEG2000-stearic acid (PEG2000-SA) as hydrophilic groups. Surface properties, cytotoxicity, cellular uptake, and transport across Caco-2/HT29 coculture cell monolayers, intestinal absorption, and pharmacokinetics of pSLN were studied compared with that of SLN. Quantitative cellular uptake showed that the internalization of SLN and pSLN was an active transfer process, which would be restrained by several inhibitors of cell activity. Compared with SLN, the permeation ability of pSLN decreased through Caco-2 cell monolayer while it increased through a mucus-secreting Caco-2/HT29 coculture cell monolayer, which indicated that the mucus layer has a significant impact on determining the efficiency of oral nanoformulations. In addition to increasing permeation ability, the stability of the nanoparticles in simulated intestinal fluids was also increased by the PEGylation. Moreover, in vitro everted gut sac technique and the ligated intestinal loops model in vivo also demonstrated that pSLN can rapidly penetrate mucus secretions, whereas the SLN were strongly trapped by highly viscoelastic mucus barriers. The pharmacokinetic studies presented that pSLN exhibited improved absorption efficiency and prolonged blood circulation times with a 1.99-fold higher relative bioavailability compared with SLN. In conclusion, PEGylated solid lipid nanoparticles had advantages in enhancing the bioavailability of oral administration." @default.
• W2052804020 created "2016-06-24" @default.
• W2052804020 creator A5010773627 @default.
• W2052804020 creator A5015921335 @default.
• W2052804020 creator A5023586508 @default.
• W2052804020 creator A5041836364 @default.
• W2052804020 creator A5063420905 @default.
• W2052804020 date "2013-04-05" @default.
• W2052804020 modified "2023-10-18" @default.
• W2052804020 title "Improved Transport and Absorption through Gastrointestinal Tract by PEGylated Solid Lipid Nanoparticles" @default.
• W2052804020 cites W1582634852 @default.
• W2052804020 cites W1967105417 @default.
• W2052804020 cites W1968323648 @default.
• W2052804020 cites W1987673164 @default.
• W2052804020 cites W1988897404 @default.
• W2052804020 cites W1994294415 @default.
• W2052804020 cites W2019124020 @default.
• W2052804020 cites W2021849780 @default.
• W2052804020 cites W2022905205 @default.
• W2052804020 cites W2024112019 @default.
• W2052804020 cites W2025295270 @default.
• W2052804020 cites W2027889438 @default.
• W2052804020 cites W2029749273 @default.
• W2052804020 cites W2045390594 @default.
• W2052804020 cites W2055037481 @default.
• W2052804020 cites W2055249600 @default.
• W2052804020 cites W2055449190 @default.
• W2052804020 cites W2055454300 @default.
• W2052804020 cites W2057650100 @default.
• W2052804020 cites W2060265857 @default.
• W2052804020 cites W2064747589 @default.
• W2052804020 cites W2071026997 @default.
• W2052804020 cites W2074037814 @default.
• W2052804020 cites W2076737646 @default.
• W2052804020 cites W2079667908 @default.
• W2052804020 cites W2083187826 @default.
• W2052804020 cites W2085248976 @default.
• W2052804020 cites W2092370160 @default.
• W2052804020 cites W2103908542 @default.
• W2052804020 cites W2121762824 @default.
• W2052804020 cites W2124140010 @default.
• W2052804020 cites W2154855352 @default.
• W2052804020 cites W2160651357 @default.
• W2052804020 doi "https://doi.org/10.1021/mp300649z" @default.
• W2052804020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23495754" @default.
• W2052804020 hasPublicationYear "2013" @default.
• W2052804020 type Work @default.
• W2052804020 sameAs 2052804020 @default.
• W2052804020 citedByCount "187" @default.
• W2052804020 countsByYear W20528040202014 @default.
• W2052804020 countsByYear W20528040202015 @default.
• W2052804020 countsByYear W20528040202016 @default.
• W2052804020 countsByYear W20528040202017 @default.
• W2052804020 countsByYear W20528040202018 @default.
• W2052804020 countsByYear W20528040202019 @default.
• W2052804020 countsByYear W20528040202020 @default.
• W2052804020 countsByYear W20528040202021 @default.
• W2052804020 countsByYear W20528040202022 @default.
• W2052804020 countsByYear W20528040202023 @default.
• W2052804020 crossrefType "journal-article" @default.
• W2052804020 hasAuthorship W2052804020A5010773627 @default.
• W2052804020 hasAuthorship W2052804020A5015921335 @default.
• W2052804020 hasAuthorship W2052804020A5023586508 @default.
• W2052804020 hasAuthorship W2052804020A5041836364 @default.
• W2052804020 hasAuthorship W2052804020A5063420905 @default.
• W2052804020 hasConcept C112705442 @default.
• W2052804020 hasConcept C120882062 @default.
• W2052804020 hasConcept C125287762 @default.
• W2052804020 hasConcept C12554922 @default.
• W2052804020 hasConcept C150903083 @default.
• W2052804020 hasConcept C159985019 @default.
• W2052804020 hasConcept C178790620 @default.
• W2052804020 hasConcept C181389837 @default.
• W2052804020 hasConcept C185592680 @default.
• W2052804020 hasConcept C18903297 @default.
• W2052804020 hasConcept C192562407 @default.
• W2052804020 hasConcept C193176779 @default.
• W2052804020 hasConcept C199529486 @default.
• W2052804020 hasConcept C201399114 @default.
• W2052804020 hasConcept C202751555 @default.
• W2052804020 hasConcept C207001950 @default.
• W2052804020 hasConcept C2776964284 @default.
• W2052804020 hasConcept C2777312293 @default.
• W2052804020 hasConcept C2779149719 @default.
• W2052804020 hasConcept C2779820397 @default.
• W2052804020 hasConcept C41625074 @default.
• W2052804020 hasConcept C43617362 @default.
• W2052804020 hasConcept C50670333 @default.
• W2052804020 hasConcept C55493867 @default.
• W2052804020 hasConcept C60903277 @default.
• W2052804020 hasConcept C86803240 @default.
• W2052804020 hasConcept C98274493 @default.
• W2052804020 hasConceptScore W2052804020C112705442 @default.
• W2052804020 hasConceptScore W2052804020C120882062 @default.
• W2052804020 hasConceptScore W2052804020C125287762 @default.
• W2052804020 hasConceptScore W2052804020C12554922 @default.
• W2052804020 hasConceptScore W2052804020C150903083 @default.
• W2052804020 hasConceptScore W2052804020C159985019 @default.

• next