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- W2052804112 abstract "Lyme disease is the most common arthropod-borne disease in North America and Europe. At present, there is no commercially available vaccine for use in humans. Outer surface protein C (OspC) has antigenic and expression characteristics that make it an attractive vaccine candidate; however, sequence heterogeneity has impeded its use as a vaccinogen. Sequence analyses have identified 21 well defined OspC phyletic groups or types (designated A-U). In this report we have mapped the linear epitopes presented by OspC types B, K, and D during human and murine infection and exploited these epitopes (along with the previously identified type A OspC linear epitopes) in the development of a recombinant, tetravalent, chimeric vaccinogen. The construct was found to be highly immunogenic in mice and the induced antibodies surface labeled in vitro cultivated spirochetes. Importantly, vaccination induced complement-dependent bactericidal antibodies against strains expressing each of the OspC types that were incorporated into the construct. These results suggest that an effective and broadly protective polyvalent OspC-based Lyme disease vaccine can be produced as a recombinant, chimeric protein." @default.
- W2052804112 created "2016-06-24" @default.
- W2052804112 creator A5006028509 @default.
- W2052804112 creator A5009022430 @default.
- W2052804112 creator A5013009460 @default.
- W2052804112 date "2007-01-01" @default.
- W2052804112 modified "2023-10-18" @default.
- W2052804112 title "Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains" @default.
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- W2052804112 doi "https://doi.org/10.1016/j.vaccine.2006.07.052" @default.
- W2052804112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16996663" @default.
- W2052804112 hasPublicationYear "2007" @default.
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