FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052807450> ?p ?o ?g. }

• W2052807450 endingPage "159" @default.
• W2052807450 startingPage "147" @default.
• W2052807450 abstract "Although severe acidosis is an important mediator of brain infarction, recent evidence suggests that mild acidosis may protect ischemic cells. The HSP70 heat shock protein is induced by acidosis in cultured cells and in ischemic brain and protects cells against many types of injury. Therefore, this study determined whether induction of heat shock proteins protects cultured astrocytes against acidosis. Brief exposure of cultured cortical astrocytes to acid (pH 5.2 for 40 min) or heat shock (45 degrees C for 40 min) markedly induced hsp70 mRNA and HSP70 protein. HSP70 protein was detected with the C92 monoclonal antibody (Welch and Suhan: J Cell Biol 103:2035, 1986), which has been shown to recognize the protein product of the full-length rat hsp70 cDNA (Longo et al: J Neurosci Res 36:325, 1993). Heat shock of the cultured cortical astrocytes completely protected the astrocytes from an otherwise lethal heat exposure 24 h later (45 degrees C for 4 h). In contrast, heat pretreatment sensitized the astrocytes to injury from acidosis 24 h later. Acid pretreatment, which markedly induced the HSP70 protein without producing astrocytic cell death, similarly sensitized the cells to injury from acidosis 24 h later (60% survival following pH 5.2 for 3 h versus 90% survival in controls; P < 0.0001). Surprisingly, heat shock pretreatment protected astrocytes against exposure to acid 48 h later (P < 0.05, 1.5-3 h), whereas acid pretreatment had no effect on astrocyte survival 48 h later. Since heat shock did not protect against acidosis at 24 h when HSP70 induction was maximal but did protect at 48 h when HSP70 was markedly diminished, the protective effect of heat shock at 48 h may be related to stress proteins present at 48 h. It is concluded that induction of HSP70 and other heat shock proteins by heat shock protects astrocytes against subsequent lethal heat shock. However, heat shock and acid treatment increase the vulnerability of astrocytes to acidosis 24 h later in spite of the induction of HSP70 heat shock proteins. The finding that heat shock protected astrocytes against acidosis 2 days later may suggest that delayed induction of stress proteins partially protects the astrocytes against damage produced by high concentrations of hydrogen ions." @default.
• W2052807450 created "2016-06-24" @default.
• W2052807450 creator A5021502220 @default.
• W2052807450 creator A5022193976 @default.
• W2052807450 creator A5056512048 @default.
• W2052807450 creator A5077204734 @default.
• W2052807450 date "1996-06-01" @default.
• W2052807450 modified "2023-09-24" @default.
• W2052807450 title "Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis" @default.
• W2052807450 cites W107155627 @default.
• W2052807450 cites W1509313163 @default.
• W2052807450 cites W1563482856 @default.
• W2052807450 cites W1700037487 @default.
• W2052807450 cites W1759315945 @default.
• W2052807450 cites W1765301676 @default.
• W2052807450 cites W1875907860 @default.
• W2052807450 cites W1896790020 @default.
• W2052807450 cites W1971819783 @default.
• W2052807450 cites W1973396166 @default.
• W2052807450 cites W1980572916 @default.
• W2052807450 cites W1984457480 @default.
• W2052807450 cites W1984803289 @default.
• W2052807450 cites W1991237280 @default.
• W2052807450 cites W1996830959 @default.
• W2052807450 cites W1998621123 @default.
• W2052807450 cites W2001135187 @default.
• W2052807450 cites W2001239055 @default.
• W2052807450 cites W2003088600 @default.
• W2052807450 cites W2004462638 @default.
• W2052807450 cites W2006659499 @default.
• W2052807450 cites W2011812923 @default.
• W2052807450 cites W2013024855 @default.
• W2052807450 cites W2013317828 @default.
• W2052807450 cites W2014057737 @default.
• W2052807450 cites W2014232749 @default.
• W2052807450 cites W2016575029 @default.
• W2052807450 cites W2017053170 @default.
• W2052807450 cites W2019079217 @default.
• W2052807450 cites W2021497992 @default.
• W2052807450 cites W2021946448 @default.
• W2052807450 cites W2022887086 @default.
• W2052807450 cites W2027840396 @default.
• W2052807450 cites W2028746054 @default.
• W2052807450 cites W2029739901 @default.
• W2052807450 cites W2029794817 @default.
• W2052807450 cites W2033275198 @default.
• W2052807450 cites W2039804718 @default.
• W2052807450 cites W2040857325 @default.
• W2052807450 cites W2046355508 @default.
• W2052807450 cites W2048053028 @default.
• W2052807450 cites W2048788380 @default.
• W2052807450 cites W2049587547 @default.
• W2052807450 cites W2052875832 @default.
• W2052807450 cites W2055533988 @default.
• W2052807450 cites W2056413304 @default.
• W2052807450 cites W2060071007 @default.
• W2052807450 cites W2068396538 @default.
• W2052807450 cites W2069496768 @default.
• W2052807450 cites W2072032770 @default.
• W2052807450 cites W2073383715 @default.
• W2052807450 cites W2075577711 @default.
• W2052807450 cites W2075715499 @default.
• W2052807450 cites W2076535641 @default.
• W2052807450 cites W2079115295 @default.
• W2052807450 cites W2085273994 @default.
• W2052807450 cites W2088378668 @default.
• W2052807450 cites W2090138476 @default.
• W2052807450 cites W2091463896 @default.
• W2052807450 cites W2092392225 @default.
• W2052807450 cites W2094164804 @default.
• W2052807450 cites W2094358812 @default.
• W2052807450 cites W2102654854 @default.
• W2052807450 cites W2104755183 @default.
• W2052807450 cites W2108721148 @default.
• W2052807450 cites W2119023895 @default.
• W2052807450 cites W2121496941 @default.
• W2052807450 cites W2123927909 @default.
• W2052807450 cites W2127744856 @default.
• W2052807450 cites W2137417707 @default.
• W2052807450 cites W2140834315 @default.
• W2052807450 cites W2148880229 @default.
• W2052807450 cites W2164340078 @default.
• W2052807450 cites W2329887489 @default.
• W2052807450 cites W265398678 @default.
• W2052807450 cites W4211239749 @default.
• W2052807450 cites W4240169433 @default.
• W2052807450 cites W6973128 @default.
• W2052807450 doi "https://doi.org/10.1002/(sici)1098-1136(199606)17:2<147::aid-glia6>3.0.co;2-#" @default.
• W2052807450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8776581" @default.
• W2052807450 hasPublicationYear "1996" @default.
• W2052807450 type Work @default.
• W2052807450 sameAs 2052807450 @default.
• W2052807450 citedByCount "16" @default.
• W2052807450 countsByYear W20528074502021 @default.
• W2052807450 countsByYear W20528074502022 @default.
• W2052807450 crossrefType "journal-article" @default.
• W2052807450 hasAuthorship W2052807450A5021502220 @default.
• W2052807450 hasAuthorship W2052807450A5022193976 @default.

• next