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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052807713> ?p ?o ?g. }

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• W2052807713 abstract "Platelet-activating factor (PAF; 100 ng i.v.) transiently modified the number of circulating neutrophils in the mouse, inducing a fast neutropenia (2 min) followed by a late onset neutrophilia (2 h). The potential involvement in PAF-induced neutrophilia of granulocytotic agents such as interleukin-1 and tumor necrosis factor-α could be excluded on the basis of the ineffectiveness of interleukin-1 receptor antagonist and of a specific monoclonal antibody anti-murine tumor necrosis factor-α. PAF granulocytosis was preceded by a significant rise in plasma corticosterone at 20 min. The involvement of endogenous corticosteroids was confirmed by the experiments with adrenalectomized mice and in animals pretreated with the steroid antagonist RU486 (11β-(4-dimethyl amino-phenyl) 17β-hydroxy, 17α(prop-1-ynyl) estra 4,9-dien-3-one), where PAF-induced neutrophilia was greatly reduced (∼50%). Moreover, sustained increase in plasma corticosterone by administration of adrenocorticotropic hormone was paralleled by an intense neutrophilia. We show evidence that endogenous corticosterone acts through the glucocorticoid-inducible protein lipocortin 1." @default.
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• W2052807713 date "1995-09-01" @default.
• W2052807713 modified "2023-09-29" @default.
• W2052807713 title "Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse" @default.
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• W2052807713 doi "https://doi.org/10.1016/0014-2999(95)00274-o" @default.
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