FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052807764> ?p ?o ?g. }

• W2052807764 endingPage "140" @default.
• W2052807764 startingPage "133" @default.
• W2052807764 abstract "Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic syndrome characterized by small accumulations of CD5+ B lymphocytes. Most MBL share phenotypic characteristics with chronic lymphocytic leukemia (CLL). Although some MBL progress to CLL, most MBL have apparently limited potential for progression to CLL, particularly those MBL with normal absolute B-cell counts (‘low-count’ MBL). Most CLL are monoclonal and it is not known whether MBL are monoclonal or oligoclonal; this is important because it is unclear whether MBL represent indolent CLL or represent a distinct premalignant precursor before the development of CLL. We used flow cytometry analysis and sorting to determine immunophenotypic characteristics, clonality and molecular features of MBL from familial CLL kindreds. Single-cell analysis indicated four of six low-count MBL consisted of two or more unrelated clones; the other two MBL were monoclonal. 87% of low-count MBL clones had mutated immunoglobulin genes, and no immunoglobulin heavy-chain rearrangements of VH family 1 were observed. Some MBL were diversified, clonally related populations with evidence of antigen drive. We conclude that although low-count MBL share many phenotypic characteristics with CLL, many MBL are oligoclonal. This supports a model for step-wise development of MBL into CLL." @default.
• W2052807764 created "2016-06-24" @default.
• W2052807764 creator A5007388681 @default.
• W2052807764 creator A5012711544 @default.
• W2052807764 creator A5019460094 @default.
• W2052807764 creator A5028590946 @default.
• W2052807764 creator A5038259194 @default.
• W2052807764 creator A5056470372 @default.
• W2052807764 creator A5056482233 @default.
• W2052807764 creator A5065233200 @default.
• W2052807764 creator A5075225618 @default.
• W2052807764 date "2009-10-15" @default.
• W2052807764 modified "2023-10-13" @default.
• W2052807764 title "Single-cell analysis reveals oligoclonality among ‘low-count’ monoclonal B-cell lymphocytosis" @default.
• W2052807764 cites W1527161131 @default.
• W2052807764 cites W1910623697 @default.
• W2052807764 cites W1987288688 @default.
• W2052807764 cites W1993986769 @default.
• W2052807764 cites W1995414211 @default.
• W2052807764 cites W2016191976 @default.
• W2052807764 cites W2020924517 @default.
• W2052807764 cites W2025463888 @default.
• W2052807764 cites W2036384264 @default.
• W2052807764 cites W2038800779 @default.
• W2052807764 cites W2040168338 @default.
• W2052807764 cites W2047569578 @default.
• W2052807764 cites W2048080977 @default.
• W2052807764 cites W2048663795 @default.
• W2052807764 cites W2049372901 @default.
• W2052807764 cites W2051321376 @default.
• W2052807764 cites W2051665175 @default.
• W2052807764 cites W2062581231 @default.
• W2052807764 cites W2064208882 @default.
• W2052807764 cites W2066896776 @default.
• W2052807764 cites W2067005655 @default.
• W2052807764 cites W2077679863 @default.
• W2052807764 cites W2086703018 @default.
• W2052807764 cites W2092413851 @default.
• W2052807764 cites W2092912310 @default.
• W2052807764 cites W2097120168 @default.
• W2052807764 cites W2111609050 @default.
• W2052807764 cites W2113169771 @default.
• W2052807764 cites W2119900897 @default.
• W2052807764 cites W2135314242 @default.
• W2052807764 cites W2140880663 @default.
• W2052807764 cites W2142099365 @default.
• W2052807764 cites W2144857218 @default.
• W2052807764 cites W2145777118 @default.
• W2052807764 cites W2156804837 @default.
• W2052807764 cites W2168354492 @default.
• W2052807764 cites W2318933236 @default.
• W2052807764 cites W3208816173 @default.
• W2052807764 cites W4213085061 @default.
• W2052807764 cites W60865865 @default.
• W2052807764 doi "https://doi.org/10.1038/leu.2009.192" @default.
• W2052807764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2806490" @default.
• W2052807764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19946263" @default.
• W2052807764 hasPublicationYear "2009" @default.
• W2052807764 type Work @default.
• W2052807764 sameAs 2052807764 @default.
• W2052807764 citedByCount "61" @default.
• W2052807764 countsByYear W20528077642012 @default.
• W2052807764 countsByYear W20528077642013 @default.
• W2052807764 countsByYear W20528077642014 @default.
• W2052807764 countsByYear W20528077642015 @default.
• W2052807764 countsByYear W20528077642016 @default.
• W2052807764 countsByYear W20528077642017 @default.
• W2052807764 countsByYear W20528077642018 @default.
• W2052807764 countsByYear W20528077642019 @default.
• W2052807764 countsByYear W20528077642020 @default.
• W2052807764 countsByYear W20528077642021 @default.
• W2052807764 countsByYear W20528077642022 @default.
• W2052807764 countsByYear W20528077642023 @default.
• W2052807764 crossrefType "journal-article" @default.
• W2052807764 hasAuthorship W2052807764A5007388681 @default.
• W2052807764 hasAuthorship W2052807764A5012711544 @default.
• W2052807764 hasAuthorship W2052807764A5019460094 @default.
• W2052807764 hasAuthorship W2052807764A5028590946 @default.
• W2052807764 hasAuthorship W2052807764A5038259194 @default.
• W2052807764 hasAuthorship W2052807764A5056470372 @default.
• W2052807764 hasAuthorship W2052807764A5056482233 @default.
• W2052807764 hasAuthorship W2052807764A5065233200 @default.
• W2052807764 hasAuthorship W2052807764A5075225618 @default.
• W2052807764 hasBestOaLocation W20528077642 @default.
• W2052807764 hasConcept C113067387 @default.
• W2052807764 hasConcept C159654299 @default.
• W2052807764 hasConcept C163864487 @default.
• W2052807764 hasConcept C196166836 @default.
• W2052807764 hasConcept C203014093 @default.
• W2052807764 hasConcept C2777938653 @default.
• W2052807764 hasConcept C2778461978 @default.
• W2052807764 hasConcept C2780126324 @default.
• W2052807764 hasConcept C542903549 @default.
• W2052807764 hasConcept C553184892 @default.
• W2052807764 hasConcept C86803240 @default.
• W2052807764 hasConceptScore W2052807764C113067387 @default.
• W2052807764 hasConceptScore W2052807764C159654299 @default.
• W2052807764 hasConceptScore W2052807764C163864487 @default.

• next