FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052808053> ?p ?o ?g. }

• W2052808053 endingPage "188" @default.
• W2052808053 startingPage "169" @default.
• W2052808053 abstract "The expression of genes coding for the beta 1-adrenergic receptor (beta 1-AR), the alpha subunit of Gs and total myosin heavy chain (MHC) was compared between left ventricles (LV's) from young (6-7 weeks old) and old (22 months old) rats. The mRNA levels were quantitated by Northern or Slot blots analyses using specific DNA probes. Ageing was found to be associated with a reduction in beta 1-AR (77%), G alpha s (33%) and, total MHC (51%) mRNA levels with no concomitant change in 18S RNA and poly(A+) mRNA levels. These results indicate that transcriptional and/or post-transcriptional mechanisms participate in the control of beta-adrenergic receptor density during ageing. As in the senescent LV, beta 1-AR mRNA level is reduced in the hypertrophied LV, whereas the level of G alpha s mRNA is reduced in the senescent but not in the hypertrophied LV. From our data we conclude (1) that a dual mechanism may operate during ageing, mechanical factors indirectly regulating beta 1-AR mRNA level, while changes in G alpha s mRNA level do not depend on hemodynamic load and (2) that the re-expression of beta-MHC mRNA does not compensate for the decreased accumulation of alpha-MHC mRNA which results in a large decrease in the level of total MHC mRNA in the senescent LV." @default.
• W2052808053 created "2016-06-24" @default.
• W2052808053 creator A5003731626 @default.
• W2052808053 creator A5013905067 @default.
• W2052808053 creator A5031198626 @default.
• W2052808053 creator A5032307650 @default.
• W2052808053 creator A5050367258 @default.
• W2052808053 creator A5056043654 @default.
• W2052808053 date "1993-10-01" @default.
• W2052808053 modified "2023-09-26" @default.
• W2052808053 title "Decreased accumulation of β1-adrenergic receptor, Gαs and total myosin heavy chain messenger RNAs in the left ventricle of senescent rat heart" @default.
• W2052808053 cites W1504260229 @default.
• W2052808053 cites W1505544453 @default.
• W2052808053 cites W1548179807 @default.
• W2052808053 cites W1548579074 @default.
• W2052808053 cites W1568073470 @default.
• W2052808053 cites W1571926774 @default.
• W2052808053 cites W1580970296 @default.
• W2052808053 cites W1589424070 @default.
• W2052808053 cites W1609528353 @default.
• W2052808053 cites W1965820804 @default.
• W2052808053 cites W1980373909 @default.
• W2052808053 cites W1997541816 @default.
• W2052808053 cites W2006229710 @default.
• W2052808053 cites W2014669590 @default.
• W2052808053 cites W2016615402 @default.
• W2052808053 cites W2020090580 @default.
• W2052808053 cites W2029073799 @default.
• W2052808053 cites W203535368 @default.
• W2052808053 cites W2043351617 @default.
• W2052808053 cites W2046126244 @default.
• W2052808053 cites W2050326480 @default.
• W2052808053 cites W2051287222 @default.
• W2052808053 cites W2052756285 @default.
• W2052808053 cites W2076424155 @default.
• W2052808053 cites W2080199804 @default.
• W2052808053 cites W2091343613 @default.
• W2052808053 cites W2101076761 @default.
• W2052808053 cites W2104941760 @default.
• W2052808053 cites W2106513436 @default.
• W2052808053 cites W2110983953 @default.
• W2052808053 cites W2112852642 @default.
• W2052808053 cites W2117253018 @default.
• W2052808053 cites W2135877040 @default.
• W2052808053 cites W2140667188 @default.
• W2052808053 cites W2144219092 @default.
• W2052808053 cites W2151355563 @default.
• W2052808053 cites W2160392761 @default.
• W2052808053 cites W2162343610 @default.
• W2052808053 cites W2176077554 @default.
• W2052808053 cites W4294216491 @default.
• W2052808053 cites W989323198 @default.
• W2052808053 doi "https://doi.org/10.1016/0047-6374(93)90082-3" @default.
• W2052808053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8133675" @default.
• W2052808053 hasPublicationYear "1993" @default.
• W2052808053 type Work @default.
• W2052808053 sameAs 2052808053 @default.
• W2052808053 citedByCount "16" @default.
• W2052808053 countsByYear W20528080532021 @default.
• W2052808053 crossrefType "journal-article" @default.
• W2052808053 hasAuthorship W2052808053A5003731626 @default.
• W2052808053 hasAuthorship W2052808053A5013905067 @default.
• W2052808053 hasAuthorship W2052808053A5031198626 @default.
• W2052808053 hasAuthorship W2052808053A5032307650 @default.
• W2052808053 hasAuthorship W2052808053A5050367258 @default.
• W2052808053 hasAuthorship W2052808053A5056043654 @default.
• W2052808053 hasConcept C104317684 @default.
• W2052808053 hasConcept C105580179 @default.
• W2052808053 hasConcept C126322002 @default.
• W2052808053 hasConcept C134018914 @default.
• W2052808053 hasConcept C150194340 @default.
• W2052808053 hasConcept C170493617 @default.
• W2052808053 hasConcept C177707886 @default.
• W2052808053 hasConcept C2778921608 @default.
• W2052808053 hasConcept C40465926 @default.
• W2052808053 hasConcept C500499127 @default.
• W2052808053 hasConcept C522857546 @default.
• W2052808053 hasConcept C54355233 @default.
• W2052808053 hasConcept C6997183 @default.
• W2052808053 hasConcept C71924100 @default.
• W2052808053 hasConcept C86803240 @default.
• W2052808053 hasConcept C95444343 @default.
• W2052808053 hasConceptScore W2052808053C104317684 @default.
• W2052808053 hasConceptScore W2052808053C105580179 @default.
• W2052808053 hasConceptScore W2052808053C126322002 @default.
• W2052808053 hasConceptScore W2052808053C134018914 @default.
• W2052808053 hasConceptScore W2052808053C150194340 @default.
• W2052808053 hasConceptScore W2052808053C170493617 @default.
• W2052808053 hasConceptScore W2052808053C177707886 @default.
• W2052808053 hasConceptScore W2052808053C2778921608 @default.
• W2052808053 hasConceptScore W2052808053C40465926 @default.
• W2052808053 hasConceptScore W2052808053C500499127 @default.
• W2052808053 hasConceptScore W2052808053C522857546 @default.
• W2052808053 hasConceptScore W2052808053C54355233 @default.
• W2052808053 hasConceptScore W2052808053C6997183 @default.
• W2052808053 hasConceptScore W2052808053C71924100 @default.
• W2052808053 hasConceptScore W2052808053C86803240 @default.
• W2052808053 hasConceptScore W2052808053C95444343 @default.

• next