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• W2052808057 abstract "This randomized, double‐blind, placebo‐controlled study compared the efficacy of inhaled nitrous oxide (N 2 O) with enteral midazolam for sedation of children with cerebral palsy (CP) undergoing botulinum toxin A (BoNT‐A) injections. Fifty children (29 males, 21 females; mean age 8y 2mo [SD 4y 5mo]; range 1–16y) were randomized to sedation with N 2 O ( n =25) or midazolam ( n =25). Groups were similar in type of CP (diplegia, 11; triplegia, three; quadriplegia, 16; hemiplegia, 16; other, three) and Gross Motor Function Classification System level (Level I, 4; II, 24; III, 4; IV, 13; V, 5). Both groups were equally sedated at time of injection ( p =0.661), but those in the midazolam group were more sedated at time of discharge ( p <0.001). N 2 O was more effective in reducing pain compared with midazolam as measured using the Face, Legs, Activity, Cry, Consolability (FLACC) scale ( p =0.010), parental estimate of pain ( p =0.009), and nursing estimate of pain ( p =0.007). Parents in the N 2 O group rated it better than prior sedation with midazolam for BoNT‐A injections ( p =0.031). Physicians and nurses reported no difference in ease of procedure between the groups. One child in the midazolam group and eight in the N 2 O group had adverse effects, all of which resolved promptly. N 2 O appears to be an effective means of sedation for children undergoing outpatient BoNT‐A injections." @default.
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• W2052808057 date "2008-10-15" @default.
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• W2052808057 title "Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children" @default.
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• W2052808057 doi "https://doi.org/10.1111/j.1469-8749.2008.03069.x" @default.
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