FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052809998> ?p ?o ?g. }

• W2052809998 endingPage "493" @default.
• W2052809998 startingPage "479" @default.
• W2052809998 abstract "1. Two concentration-dependent effects of the muscarinic agonist carbachol (CCh) were characterized in submerged slices of rat hippocampus using extracellular recordings of excitatory postsynaptic potentials (EPSPs): muscarinic long-term potentiation (LTP(m)) and depression. 2. LTP(m) of the EPSP slope was seen following long exposure (20 min) of the slice to low concentrations of CCh (0.2-0.5 microM). This LTP(m) was not accompanied by a change in the size of the afferent fibre volley or by a change in paired-pulse potentiation, consistent with a postsynaptic locus of CCh action. 3. Intracellular recordings from voltage-clamped neurons of inward current evoked by iontophoretically applied alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) revealed that, while cellular responses to NMDA rose transiently upon superfusion with 0.5 microM CCh, responses to AMPA increased gradually and remained potentiated after washout of CCh. 4. LTP(m) is mediated by an M2 muscarinic receptor. Two M2 muscarinic receptor antagonists, methoctramine and AFDX-116, blocked LTP(m). The M2 agonist oxotremorine induced LTP(m) at low agonist concentrations. None of the M1 and M3 receptor agonists and antagonists tested affected LTP(m). 5. Muscarinic fast onset depression of the EPSP was seen in response to higher concentrations of CCh (2-5 mu M). This depression was accompanied by an increase in paired-pulse potentiation, indicating a possible presynaptic locus of action. The M3 muscarinic receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) blocked the muscarinic depression of the EPSP slope. M1, M2 and M4 muscarinic antagonists did not block this response. 6. Blockade of the muscarinic depression by 4-DAMP did not uncover a suppressed LTP(m). However, addition of picrotoxin facilitated the expression of LTP(m) induced by high concentrations of CCh, indicating an involvement of interneurons in regulation of LTP(m). 7. Cholinergic denervation produced by fimbria-fornix transection resulted in supersensitivity of both M2- and M3-mediated effects, indicating that the receptors mediating these effects are not located on presynaptic cholinergic fibres. In the presence of 4-DAMP and picrotoxin the dose-response curve for CCh-induced effects in slices from lesioned animals was shifted to the left relative to that of normal animals, indicating a supersensitivity of both receptor types." @default.
• W2052809998 created "2016-06-24" @default.
• W2052809998 creator A5023834518 @default.
• W2052809998 creator A5028740326 @default.
• W2052809998 date "1996-04-15" @default.
• W2052809998 modified "2023-10-01" @default.
• W2052809998 title "Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus." @default.
• W2052809998 cites W1602004204 @default.
• W2052809998 cites W1878271255 @default.
• W2052809998 cites W1891830549 @default.
• W2052809998 cites W1959981723 @default.
• W2052809998 cites W1975575774 @default.
• W2052809998 cites W1987454793 @default.
• W2052809998 cites W1992349983 @default.
• W2052809998 cites W1994067502 @default.
• W2052809998 cites W1998603233 @default.
• W2052809998 cites W2006517056 @default.
• W2052809998 cites W2009522375 @default.
• W2052809998 cites W2009782005 @default.
• W2052809998 cites W2020811915 @default.
• W2052809998 cites W2027030497 @default.
• W2052809998 cites W2028996074 @default.
• W2052809998 cites W2031811225 @default.
• W2052809998 cites W2032118090 @default.
• W2052809998 cites W2036511134 @default.
• W2052809998 cites W2037530651 @default.
• W2052809998 cites W2040166152 @default.
• W2052809998 cites W2044336688 @default.
• W2052809998 cites W2049511526 @default.
• W2052809998 cites W2059793741 @default.
• W2052809998 cites W2069804779 @default.
• W2052809998 cites W2071637530 @default.
• W2052809998 cites W2072926455 @default.
• W2052809998 cites W2073965502 @default.
• W2052809998 cites W2098466209 @default.
• W2052809998 cites W2117583411 @default.
• W2052809998 cites W2160356704 @default.
• W2052809998 cites W2160391712 @default.
• W2052809998 cites W2166662540 @default.
• W2052809998 cites W2262864571 @default.
• W2052809998 cites W2305804775 @default.
• W2052809998 cites W2335952218 @default.
• W2052809998 doi "https://doi.org/10.1113/jphysiol.1996.sp021323" @default.
• W2052809998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1158842" @default.
• W2052809998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9019544" @default.
• W2052809998 hasPublicationYear "1996" @default.
• W2052809998 type Work @default.
• W2052809998 sameAs 2052809998 @default.
• W2052809998 citedByCount "159" @default.
• W2052809998 countsByYear W20528099982012 @default.
• W2052809998 countsByYear W20528099982013 @default.
• W2052809998 countsByYear W20528099982014 @default.
• W2052809998 countsByYear W20528099982015 @default.
• W2052809998 countsByYear W20528099982016 @default.
• W2052809998 countsByYear W20528099982017 @default.
• W2052809998 countsByYear W20528099982018 @default.
• W2052809998 countsByYear W20528099982019 @default.
• W2052809998 countsByYear W20528099982020 @default.
• W2052809998 countsByYear W20528099982021 @default.
• W2052809998 countsByYear W20528099982023 @default.
• W2052809998 crossrefType "journal-article" @default.
• W2052809998 hasAuthorship W2052809998A5023834518 @default.
• W2052809998 hasAuthorship W2052809998A5028740326 @default.
• W2052809998 hasBestOaLocation W20528099982 @default.
• W2052809998 hasConcept C112592302 @default.
• W2052809998 hasConcept C126322002 @default.
• W2052809998 hasConcept C134018914 @default.
• W2052809998 hasConcept C160268369 @default.
• W2052809998 hasConcept C170493617 @default.
• W2052809998 hasConcept C17077164 @default.
• W2052809998 hasConcept C185592680 @default.
• W2052809998 hasConcept C197341189 @default.
• W2052809998 hasConcept C207723603 @default.
• W2052809998 hasConcept C24998067 @default.
• W2052809998 hasConcept C25274449 @default.
• W2052809998 hasConcept C2776961477 @default.
• W2052809998 hasConcept C2778824757 @default.
• W2052809998 hasConcept C2778988552 @default.
• W2052809998 hasConcept C2779600325 @default.
• W2052809998 hasConcept C33789571 @default.
• W2052809998 hasConcept C64123433 @default.
• W2052809998 hasConcept C67018056 @default.
• W2052809998 hasConcept C71924100 @default.
• W2052809998 hasConcept C73009533 @default.
• W2052809998 hasConcept C86803240 @default.
• W2052809998 hasConceptScore W2052809998C112592302 @default.
• W2052809998 hasConceptScore W2052809998C126322002 @default.
• W2052809998 hasConceptScore W2052809998C134018914 @default.
• W2052809998 hasConceptScore W2052809998C160268369 @default.
• W2052809998 hasConceptScore W2052809998C170493617 @default.
• W2052809998 hasConceptScore W2052809998C17077164 @default.
• W2052809998 hasConceptScore W2052809998C185592680 @default.
• W2052809998 hasConceptScore W2052809998C197341189 @default.
• W2052809998 hasConceptScore W2052809998C207723603 @default.
• W2052809998 hasConceptScore W2052809998C24998067 @default.
• W2052809998 hasConceptScore W2052809998C25274449 @default.
• W2052809998 hasConceptScore W2052809998C2776961477 @default.
• W2052809998 hasConceptScore W2052809998C2778824757 @default.

• next