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- W2052820003 abstract "The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced axonal growth. This approach provides a facile, general route to tailor cell membranes with biologically active glycans and demonstrates the potential to direct important cellular events through cell-surface glycan engineering." @default.
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- W2052820003 date "2014-04-30" @default.
- W2052820003 modified "2023-10-12" @default.
- W2052820003 title "Directing Neuronal Signaling through Cell-Surface Glycan Engineering" @default.
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- W2052820003 doi "https://doi.org/10.1021/ja5005174" @default.
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