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• W2052821616 abstract "Hepatitis B virus (HBV) infection in recipients may be associated with hepatitis and increased nonrelapse mortality (NRM) following unrelated-donor allogeneic hematopoietic stem cell transplantation (allo-HSCT). China is an endemic area for HBV infection. It is especially significant to clarify the true impact of HBV on outcomes of allo-HSCT as well as preventive and treatment strategies in this special population. In the current study, we performed a retrospective analysis of the virologic and clinical outcomes of HBV infection in recipients undergoing allo-HSCT with active anti-HBV prophylaxis or treatment from seronegative unrelated donors for HBV. Between 1998 and May 2009, 222 patients underwent unrelated donor allo-HSCT were enrolled. Patient information was collected from the BMT database. Anti-HBV therapy consisted of lamivudine or entecavir for HBsAg positive recipients before HSCT while marrow harvest and HSCT were performed until recipient's serum HBV-DNA became undetectable. HBV-DNA was isolated from serum with the QIAmpt blood kit and quantitatively measured using a kinetic fluorescence detection system. All of the patients were followed up in out-patient department weekly and HBV serology were detected once every month. Before transplantation, 17 patients who were positive for HBsAg and received lamivudine or entecavir prophylaxis were regarded as group 1. There was 1 case of reactivation of HBV in this group and 8 cases became negative for HBsAg and posive for HBsAb. One hundred and fifty four patients who were negative for HBsAg and anti-HBc before allo-HSCT were regarded as a control group. Fifty one patients who were negative for HBsAg and positive for anti-HBc were regarded as group 2. In the control group none was identified as positive for HBsAg after HSCT while in group 2, 2 patients developed hepatitis, thus indicating reverse seroconversion. For these 2 patients lamivudine were administered for anti-HBV therapy and 1 patients died of HBV-related hepatic failure. There were no significant differences in overall survival(OS), and incidence of acute graft-versus-host disease(GVHD) and chronic GVHD among the 3 groups. Our data suggest that HBV infection in the recipient at the time of transplantation does not seem to adversely affect outcome after allo-HSCT with active anti-HBV prophylaxis or treatment. HBV infection in the recipient is not a contraindication of allo-HSCT." @default.
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• W2052821616 date "2011-02-01" @default.
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• W2052821616 title "Virologic and Clinical Outcomes of Hepatitis B Virus Infection in Recipients Undergoing Unrelated-Donor Hematopoietic Stem Cell Transplantation" @default.
• W2052821616 doi "https://doi.org/10.1016/j.bbmt.2010.12.446" @default.
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