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- W2052824223 endingPage "410" @default.
- W2052824223 startingPage "401" @default.
- W2052824223 abstract "Characteristics of human malignant glioma are excessive proliferation, infiltrative growth, angiogenesis and suppression of anti-tumor immune surveillance. Transforming growth factor-beta (TGF-beta), a versatile cytokine, is intimately involved in the regulation of these processes. Here, we discuss the interactions of TGF-beta with growth factors, such as basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and platelet derived growth factor (PDGF), metalloproteinases (MMP-2, MMP-9) and their inhibitor, plasmin activator inhibitor-1 (PAI-1), and immune cells, like natural killer cells, T-cells and microglia. The differential effects of TGF-beta in glioma biology are outlined with emphasis on the induction of a survival advantage for glioma cells by enforced cell growth, migration, invasion, angiogenesis and immune paralysis. By virtue of its growth regulatory and immunomodulatory properties, TGF-beta promises to become a novel target for the experimental therapy of human malignant glioma." @default.
- W2052824223 created "2016-06-24" @default.
- W2052824223 creator A5017177249 @default.
- W2052824223 creator A5064778456 @default.
- W2052824223 creator A5080482957 @default.
- W2052824223 date "2001-01-01" @default.
- W2052824223 modified "2023-09-30" @default.
- W2052824223 title "Malignant glioma biology: Role for TGF-? in growth, motility, angiogenesis, and immune escape" @default.
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