Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052833065> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2052833065 abstract "Association and diffusion of peripheral proteins to the cell membrane during many signaling and trafficking events in the cell occurs via lipid-binding modules e.g. pleckstrin homology (PH) domains. PH domains are a highly structurally conserved family of proteins which is believed to associate with various phosphatidyl inositol phosphates (PIPs) molecules in the plasma membrane thus initiating multiple signaling cascades. Despite the available structural and functional data for a variety of different PH domains the diffusive and interacting dynamics of these proteins with the lipid membrane and in particular with PIP molecules has been veiled. Using a coarse-grained molecular dynamics simulation approach, we investigate the localization and dynamic of different PH domains on a lipid bilayer surface of complex phospholipid composition. Our results demonstrate that the different PH domains associate with the PIP molecules in the membrane via a highly positively charged loop in good agreement with available experimental data. We also show that translational and rotational diffusion of PH domains on the lipid membrane surface exhibit transient sub-diffusion. Moreover, we find that fluctuations of the number of PIPs binding with the PH domains exhibit 1/f noise. Constructing a dichotomous process for the number of the PIPs, we find that the process can be regarded as a correlated renewal process where residence times are correlated." @default.
- W2052833065 created "2016-06-24" @default.
- W2052833065 creator A5004379494 @default.
- W2052833065 creator A5024901095 @default.
- W2052833065 creator A5049454633 @default.
- W2052833065 creator A5050454911 @default.
- W2052833065 creator A5068989186 @default.
- W2052833065 date "2015-01-01" @default.
- W2052833065 modified "2023-09-26" @default.
- W2052833065 title "Anomalous Dynamics of Pleckstrin Homology Domains on Lipid Membrane Surfaces" @default.
- W2052833065 cites W2231559318 @default.
- W2052833065 doi "https://doi.org/10.1016/j.bpj.2014.11.1376" @default.
- W2052833065 hasPublicationYear "2015" @default.
- W2052833065 type Work @default.
- W2052833065 sameAs 2052833065 @default.
- W2052833065 citedByCount "0" @default.
- W2052833065 crossrefType "journal-article" @default.
- W2052833065 hasAuthorship W2052833065A5004379494 @default.
- W2052833065 hasAuthorship W2052833065A5024901095 @default.
- W2052833065 hasAuthorship W2052833065A5049454633 @default.
- W2052833065 hasAuthorship W2052833065A5050454911 @default.
- W2052833065 hasAuthorship W2052833065A5068989186 @default.
- W2052833065 hasBestOaLocation W20528330651 @default.
- W2052833065 hasConcept C12554922 @default.
- W2052833065 hasConcept C144647389 @default.
- W2052833065 hasConcept C147597530 @default.
- W2052833065 hasConcept C159467904 @default.
- W2052833065 hasConcept C161200384 @default.
- W2052833065 hasConcept C166311969 @default.
- W2052833065 hasConcept C178790620 @default.
- W2052833065 hasConcept C185592680 @default.
- W2052833065 hasConcept C2778918659 @default.
- W2052833065 hasConcept C32909587 @default.
- W2052833065 hasConcept C39944091 @default.
- W2052833065 hasConcept C41625074 @default.
- W2052833065 hasConcept C49658373 @default.
- W2052833065 hasConcept C55493867 @default.
- W2052833065 hasConcept C59593255 @default.
- W2052833065 hasConcept C8010536 @default.
- W2052833065 hasConcept C86803240 @default.
- W2052833065 hasConceptScore W2052833065C12554922 @default.
- W2052833065 hasConceptScore W2052833065C144647389 @default.
- W2052833065 hasConceptScore W2052833065C147597530 @default.
- W2052833065 hasConceptScore W2052833065C159467904 @default.
- W2052833065 hasConceptScore W2052833065C161200384 @default.
- W2052833065 hasConceptScore W2052833065C166311969 @default.
- W2052833065 hasConceptScore W2052833065C178790620 @default.
- W2052833065 hasConceptScore W2052833065C185592680 @default.
- W2052833065 hasConceptScore W2052833065C2778918659 @default.
- W2052833065 hasConceptScore W2052833065C32909587 @default.
- W2052833065 hasConceptScore W2052833065C39944091 @default.
- W2052833065 hasConceptScore W2052833065C41625074 @default.
- W2052833065 hasConceptScore W2052833065C49658373 @default.
- W2052833065 hasConceptScore W2052833065C55493867 @default.
- W2052833065 hasConceptScore W2052833065C59593255 @default.
- W2052833065 hasConceptScore W2052833065C8010536 @default.
- W2052833065 hasConceptScore W2052833065C86803240 @default.
- W2052833065 hasLocation W20528330651 @default.
- W2052833065 hasOpenAccess W2052833065 @default.
- W2052833065 hasPrimaryLocation W20528330651 @default.
- W2052833065 hasRelatedWork W1979492275 @default.
- W2052833065 hasRelatedWork W1982222842 @default.
- W2052833065 hasRelatedWork W1996483371 @default.
- W2052833065 hasRelatedWork W1999583932 @default.
- W2052833065 hasRelatedWork W2048384982 @default.
- W2052833065 hasRelatedWork W2053444089 @default.
- W2052833065 hasRelatedWork W2090127701 @default.
- W2052833065 hasRelatedWork W2121900866 @default.
- W2052833065 hasRelatedWork W2268478214 @default.
- W2052833065 hasRelatedWork W2285771040 @default.
- W2052833065 hasRelatedWork W2367279758 @default.
- W2052833065 hasRelatedWork W2574626594 @default.
- W2052833065 hasRelatedWork W2583733019 @default.
- W2052833065 hasRelatedWork W2801994775 @default.
- W2052833065 hasRelatedWork W2901755540 @default.
- W2052833065 hasRelatedWork W2964299823 @default.
- W2052833065 hasRelatedWork W2987852484 @default.
- W2052833065 hasRelatedWork W3186474696 @default.
- W2052833065 hasRelatedWork W3198052096 @default.
- W2052833065 hasRelatedWork W3214189920 @default.
- W2052833065 isParatext "false" @default.
- W2052833065 isRetracted "false" @default.
- W2052833065 magId "2052833065" @default.
- W2052833065 workType "article" @default.