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- W2052839211 abstract "Purpose of review Shiga toxin-producing Escherichia coli cause hemorrhagic colitis and hemolytic uremic syndrome. We will summarize the literature on incidence and outcomes of these infections, and then review the pathogenesis to explain the current recommendations against antibiotic use and to suggest alternative therapies. Recent findings Shiga toxin-producing E. coli continue to be prevalent in the industrialized world because of dissemination in food products contaminated by ruminant feces. Declines in ground beef-related outbreaks have been matched by increased cases related to green vegetables. Fifteen percent of patients infected with E. coli O157:H7 progress to hemolytic uremic syndrome, but this figure may reach 50% if antibiotics are used. Mechanisms for bacteriophage induction causing Shiga toxin production, and for Shiga toxin dissemination to endothelium in gut, kidney and brain, may explain the negative effects of antibiotics and lead to rational therapies. Shiga toxin binders were not effective in clinical trials, but more avid binding agents may be. Current treatment recommendations are to maintain hydration to prevent thrombotic complications. Human vaccines are unlikely to be utilized. Cattle vaccines may prove the most significant approach to this disease. Summary Improved understanding of Shiga toxin-producing Escherichia coli pathophysiology and progression to hemolytic uremic syndrome provides the basis for prevention, prophylactic and treatment strategies." @default.
- W2052839211 created "2016-06-24" @default.
- W2052839211 creator A5029464906 @default.
- W2052839211 creator A5064448424 @default.
- W2052839211 date "2008-01-01" @default.
- W2052839211 modified "2023-10-15" @default.
- W2052839211 title "Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections" @default.
- W2052839211 cites W1536997383 @default.
- W2052839211 cites W1907128661 @default.
- W2052839211 cites W1966684905 @default.
- W2052839211 cites W1967582134 @default.
- W2052839211 cites W1968913467 @default.
- W2052839211 cites W1969987939 @default.
- W2052839211 cites W1971429882 @default.
- W2052839211 cites W1972610369 @default.
- W2052839211 cites W1975653552 @default.
- W2052839211 cites W1983458029 @default.
- W2052839211 cites W1986890191 @default.
- W2052839211 cites W1988872042 @default.
- W2052839211 cites W1989691618 @default.
- W2052839211 cites W1992884121 @default.
- W2052839211 cites W1992888087 @default.
- W2052839211 cites W1995610766 @default.
- W2052839211 cites W1999027251 @default.
- W2052839211 cites W2004974024 @default.
- W2052839211 cites W2008738343 @default.
- W2052839211 cites W2014150586 @default.
- W2052839211 cites W2019411231 @default.
- W2052839211 cites W2020212124 @default.
- W2052839211 cites W2026552624 @default.
- W2052839211 cites W2045587232 @default.
- W2052839211 cites W2049546988 @default.
- W2052839211 cites W2051135997 @default.
- W2052839211 cites W2051312408 @default.
- W2052839211 cites W2054835420 @default.
- W2052839211 cites W2054926348 @default.
- W2052839211 cites W2059307384 @default.
- W2052839211 cites W2063363790 @default.
- W2052839211 cites W2064733096 @default.
- W2052839211 cites W2072098717 @default.
- W2052839211 cites W2074650202 @default.
- W2052839211 cites W2076891031 @default.
- W2052839211 cites W2077994831 @default.
- W2052839211 cites W2086476168 @default.
- W2052839211 cites W2091803609 @default.
- W2052839211 cites W2095744711 @default.
- W2052839211 cites W2098469764 @default.
- W2052839211 cites W2099514668 @default.
- W2052839211 cites W2108224099 @default.
- W2052839211 cites W2110212480 @default.
- W2052839211 cites W2110704759 @default.
- W2052839211 cites W2111392559 @default.
- W2052839211 cites W2112111992 @default.
- W2052839211 cites W2117614106 @default.
- W2052839211 cites W2117900265 @default.
- W2052839211 cites W2119261996 @default.
- W2052839211 cites W2122251135 @default.
- W2052839211 cites W2123992498 @default.
- W2052839211 cites W2124087841 @default.
- W2052839211 cites W2126252319 @default.
- W2052839211 cites W2129058679 @default.
- W2052839211 cites W2131096021 @default.
- W2052839211 cites W2134874804 @default.
- W2052839211 cites W2137819290 @default.
- W2052839211 cites W2137994690 @default.
- W2052839211 cites W2139912385 @default.
- W2052839211 cites W2142342354 @default.
- W2052839211 cites W2145230191 @default.
- W2052839211 cites W2145857238 @default.
- W2052839211 cites W2148120451 @default.
- W2052839211 cites W2154870173 @default.
- W2052839211 cites W2156242960 @default.
- W2052839211 cites W2156679520 @default.
- W2052839211 cites W2156850246 @default.
- W2052839211 cites W2156852846 @default.
- W2052839211 cites W2157054280 @default.
- W2052839211 cites W2158277438 @default.
- W2052839211 cites W2158301958 @default.
- W2052839211 cites W2159582451 @default.
- W2052839211 cites W2162535087 @default.
- W2052839211 cites W2168575705 @default.
- W2052839211 cites W2172184041 @default.
- W2052839211 cites W2261460288 @default.
- W2052839211 cites W2312509578 @default.
- W2052839211 cites W2324397673 @default.
- W2052839211 cites W2335304797 @default.
- W2052839211 cites W4241508796 @default.
- W2052839211 cites W4300852524 @default.
- W2052839211 cites W1569177498 @default.
- W2052839211 doi "https://doi.org/10.1097/mog.0b013e3282f2dfb8" @default.
- W2052839211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18043231" @default.
- W2052839211 hasPublicationYear "2008" @default.
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