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• W2052842511 abstract "Proteases were, for a long time, mainly considered as protein degrading enzymes. However, in the last decade this view has changed dramatically, and the focus is now on proteases as signalling molecules. One of the best examples is apoptosis, the major mechanism used by eukaryotes to remove superfluous, damaged and potentially dangerous cells, in which a number of proteases have been found to play a central role. Of these the caspases have been considered to be the major players. However, more recently, other proteases have been increasingly suggested as being important in apoptosis, in particular the cysteine cathepsins. In this review the roles of caspases and cysteine cathepsins in apoptosis signalling are compared and discussed." @default.
• W2052842511 created "2016-06-24" @default.
• W2052842511 creator A5004648655 @default.
• W2052842511 creator A5056440307 @default.
• W2052842511 date "2007-05-25" @default.
• W2052842511 modified "2023-09-30" @default.
• W2052842511 title "Protease signalling in cell death: caspases versus cysteine cathepsins" @default.
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• W2052842511 doi "https://doi.org/10.1016/j.febslet.2007.05.038" @default.
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