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- W2052852090 abstract "In order to prevent perinatal infection, the child of a hepatitis B e antigen-positive mother was given hepatitis B immune globulin and vaccinated against hepatitis B virus (HBV) at birth. Despite circulating antibody to hepatitis B surface antigen (anti-HBs), the child became infected and is a carrier. Recent serum samples show the co-existence of hepatitis B surface antigen and anti-HBs. This study tries to determine whether failure to neutralize this virus by anti-HBs was associated with a change in the amino acid sequence of the surface protein of HBV. The polymerase chain reaction was used to amplify the region of the hepatitis B surface open reading frame encoding the major antigenic determinants from serum samples taken from the child at 2, 5 and 6 years of age. Nucleotide sequence analysis of the products revealed a point mutation which resulted in a substitution of arginine for glycine at amino acid position (145) in the second loop of the a determinant." @default.
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- W2052852090 date "1993-01-01" @default.
- W2052852090 modified "2023-09-27" @default.
- W2052852090 title "Hepatitis B virus antibody escape mutant from Singapore" @default.
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- W2052852090 doi "https://doi.org/10.1111/j.1440-1746.1993.tb01688.x" @default.
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