FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052864780> ?p ?o ?g. }

• W2052864780 endingPage "967" @default.
• W2052864780 startingPage "959" @default.
• W2052864780 abstract "1. We have compared the mechanisms involved in sodium nitroprusside (SNP)-induced relaxation and [Ca2+]i reduction in isolated piglet pulmonary (PA) and mesenteric (MA) arteries. 2. SNP (10(-8) M-3x10(-5) M) evoked a concentration-dependent relaxation of PA and MA (pD2=6.66+/-0.06 and 6.74+/-0.14, respectively) stimulated by noradrenaline, which was markedly reduced by the guanylate cyclase inhibitor ODQ. In fura 2-incubated PA and MA, SNP produced a parallel reduction in contractile force and in [Ca2+]i, expressed as the ratio of emitted fluorescence at 340 and 380 nm (F340/F380). 3. The inhibition of the Na+/K+-ATPase after the incubation in a K+-free medium or the exposure to ouabain (10(-6) M) inhibited SNP-induced relaxation in MA but not in PA. SNP-induced relaxation was not attenuated by 80 mM KCl plus nifedipine (10(-6) M) but was inhibited by thapsigargin (2x10(-6) M; pD2=5.69+/-0.19 and 5.89+/-0.19 for PA and MA, respectively). 4. Pretreatment of PA with thapsigargin and MA with thapsigargin plus ouabain induced a stronger inhibition on the reduction in [Ca2+]i than on the relaxation induced by SNP, indicating the existence of Ca2+-independent mechanisms. 5. The activation of the Na+/K+-ATPase by the addition of KCl after the incubation in a K+-free medium similarly reduced [Ca2+]i in PA and MA, whereas it relaxed with much less efficacy PA than MA. 6. We conclude that SNP reduces [Ca2+]i and causes relaxation through the activation of SERCA in PA and SERCA and Na+/K+-ATPase in MA. However, Ca2+-independent mechanisms also contribute to SNP-induced effects." @default.
• W2052864780 created "2016-06-24" @default.
• W2052864780 creator A5002326750 @default.
• W2052864780 creator A5028055000 @default.
• W2052864780 creator A5062887834 @default.
• W2052864780 creator A5066202350 @default.
• W2052864780 creator A5070996492 @default.
• W2052864780 creator A5071640634 @default.
• W2052864780 creator A5091585058 @default.
• W2052864780 date "2001-02-01" @default.
• W2052864780 modified "2023-10-18" @default.
• W2052864780 title "Mechanisms involved in SNP‐induced relaxation and [Ca²⁺]_i reduction in piglet pulmonary and systemic arteries" @default.
• W2052864780 cites W1901856024 @default.
• W2052864780 cites W1917322152 @default.
• W2052864780 cites W1929009802 @default.
• W2052864780 cites W1977489807 @default.
• W2052864780 cites W1982492319 @default.
• W2052864780 cites W1993177668 @default.
• W2052864780 cites W2014195513 @default.
• W2052864780 cites W2014441605 @default.
• W2052864780 cites W2014462765 @default.
• W2052864780 cites W2016900704 @default.
• W2052864780 cites W2046246756 @default.
• W2052864780 cites W2053807796 @default.
• W2052864780 cites W2054818418 @default.
• W2052864780 cites W2062187714 @default.
• W2052864780 cites W2063302521 @default.
• W2052864780 cites W2063503589 @default.
• W2052864780 cites W2070885879 @default.
• W2052864780 cites W2073171134 @default.
• W2052864780 cites W2074222149 @default.
• W2052864780 cites W2074283871 @default.
• W2052864780 cites W2080351474 @default.
• W2052864780 cites W2081800802 @default.
• W2052864780 cites W2090968114 @default.
• W2052864780 cites W2119350257 @default.
• W2052864780 cites W2122850556 @default.
• W2052864780 cites W2123744498 @default.
• W2052864780 cites W2129895626 @default.
• W2052864780 cites W2130258723 @default.
• W2052864780 cites W2164492968 @default.
• W2052864780 cites W2217124353 @default.
• W2052864780 cites W2256724151 @default.
• W2052864780 cites W2283708574 @default.
• W2052864780 cites W2285470006 @default.
• W2052864780 cites W2320198062 @default.
• W2052864780 cites W2324162185 @default.
• W2052864780 cites W2410762046 @default.
• W2052864780 cites W2419504918 @default.
• W2052864780 cites W2591539149 @default.
• W2052864780 cites W4232368966 @default.
• W2052864780 cites W86318757 @default.
• W2052864780 doi "https://doi.org/10.1038/sj.bjp.0703894" @default.
• W2052864780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572630" @default.
• W2052864780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11181438" @default.
• W2052864780 hasPublicationYear "2001" @default.
• W2052864780 type Work @default.
• W2052864780 sameAs 2052864780 @default.
• W2052864780 citedByCount "32" @default.
• W2052864780 countsByYear W20528647802012 @default.
• W2052864780 countsByYear W20528647802013 @default.
• W2052864780 countsByYear W20528647802014 @default.
• W2052864780 countsByYear W20528647802016 @default.
• W2052864780 countsByYear W20528647802019 @default.
• W2052864780 countsByYear W20528647802020 @default.
• W2052864780 countsByYear W20528647802021 @default.
• W2052864780 countsByYear W20528647802022 @default.
• W2052864780 crossrefType "journal-article" @default.
• W2052864780 hasAuthorship W2052864780A5002326750 @default.
• W2052864780 hasAuthorship W2052864780A5028055000 @default.
• W2052864780 hasAuthorship W2052864780A5062887834 @default.
• W2052864780 hasAuthorship W2052864780A5066202350 @default.
• W2052864780 hasAuthorship W2052864780A5070996492 @default.
• W2052864780 hasAuthorship W2052864780A5071640634 @default.
• W2052864780 hasAuthorship W2052864780A5091585058 @default.
• W2052864780 hasBestOaLocation W20528647801 @default.
• W2052864780 hasConcept C12554922 @default.
• W2052864780 hasConcept C126322002 @default.
• W2052864780 hasConcept C134018914 @default.
• W2052864780 hasConcept C178790620 @default.
• W2052864780 hasConcept C185592680 @default.
• W2052864780 hasConcept C25642318 @default.
• W2052864780 hasConcept C2776029896 @default.
• W2052864780 hasConcept C2777146706 @default.
• W2052864780 hasConcept C2779066535 @default.
• W2052864780 hasConcept C2779133857 @default.
• W2052864780 hasConcept C2779610285 @default.
• W2052864780 hasConcept C519063684 @default.
• W2052864780 hasConcept C519581460 @default.
• W2052864780 hasConcept C537181965 @default.
• W2052864780 hasConcept C55493867 @default.
• W2052864780 hasConcept C71924100 @default.
• W2052864780 hasConcept C86803240 @default.
• W2052864780 hasConceptScore W2052864780C12554922 @default.
• W2052864780 hasConceptScore W2052864780C126322002 @default.
• W2052864780 hasConceptScore W2052864780C134018914 @default.
• W2052864780 hasConceptScore W2052864780C178790620 @default.
• W2052864780 hasConceptScore W2052864780C185592680 @default.

• next