FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052868904> ?p ?o ?g. }

• W2052868904 abstract "Legionella pneumophila is a facultative intracellular bacterium, capable of replicating within the phagosomes of macrophages and monocytes, but little is known about its interaction with human lung epithelial cells. We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines.Infection of L. pneumophila strain, but not heat-killed strain, resulted in upregulation of IL-8. IL-8 mRNA expression was induced immediately after the infection and its signal became gradually stronger until 24 h after infection. On the other hand, IL-8 expression in A549 cells infected with L. pneumophila lacking a functional type IV secretion system was transient. The IL-8 expression was slightly induced at 16 h and increased at 24 h after infection with flagellin-deficient Legionella. Activation of the IL-8 promoter by L. pneumophila infection occurred through the action of nuclear factor-kappaB (NF-kappaB). Transfection of dominant negative mutants of NF-kappaB-inducing kinase, IkappaB kinase and IkappaB inhibited L. pneumophila-mediated activation of IL-8 promoter. Treatment with hsp90 inhibitor suppressed L. pneumophila-induced IL-8 mRNA due to deactivation of NF-kappaB.Collectively, these results suggest that L. pneumophila induces activation of NF-kappaB through an intracellular signaling pathway that involves NF-kappaB-inducing kinase and IkappaB kinase, leading to IL-8 gene transcription, and that hsp90 acts as a crucial regulator in L. pneumophila-induced IL-8 expression, presumably contributing to immune response in L. pneumophila. The presence of flagellin and a type IV secretion system are critical for Legionella to induce IL-8 expression in lung epithelial cells." @default.
• W2052868904 created "2016-06-24" @default.
• W2052868904 creator A5002608068 @default.
• W2052868904 creator A5043654759 @default.
• W2052868904 creator A5045762902 @default.
• W2052868904 creator A5051242188 @default.
• W2052868904 creator A5055299602 @default.
• W2052868904 creator A5060145424 @default.
• W2052868904 creator A5063759119 @default.
• W2052868904 creator A5074781696 @default.
• W2052868904 creator A5077794725 @default.
• W2052868904 creator A5083666893 @default.
• W2052868904 creator A5088695508 @default.
• W2052868904 date "2007-11-22" @default.
• W2052868904 modified "2023-09-26" @default.
• W2052868904 title "Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells" @default.
• W2052868904 cites W1480945793 @default.
• W2052868904 cites W1486150850 @default.
• W2052868904 cites W1497553226 @default.
• W2052868904 cites W1573683888 @default.
• W2052868904 cites W1636221253 @default.
• W2052868904 cites W1856169132 @default.
• W2052868904 cites W1915074145 @default.
• W2052868904 cites W1963703583 @default.
• W2052868904 cites W1983424950 @default.
• W2052868904 cites W1985442806 @default.
• W2052868904 cites W1996453930 @default.
• W2052868904 cites W1997509253 @default.
• W2052868904 cites W2000109838 @default.
• W2052868904 cites W2003603336 @default.
• W2052868904 cites W2008390343 @default.
• W2052868904 cites W2018011543 @default.
• W2052868904 cites W2025583932 @default.
• W2052868904 cites W2030024653 @default.
• W2052868904 cites W2040853949 @default.
• W2052868904 cites W2049376944 @default.
• W2052868904 cites W2064851237 @default.
• W2052868904 cites W2067529967 @default.
• W2052868904 cites W2079968415 @default.
• W2052868904 cites W2087399793 @default.
• W2052868904 cites W2089478514 @default.
• W2052868904 cites W2096915882 @default.
• W2052868904 cites W2103914249 @default.
• W2052868904 cites W2106282059 @default.
• W2052868904 cites W2107674270 @default.
• W2052868904 cites W2108980965 @default.
• W2052868904 cites W2110030031 @default.
• W2052868904 cites W2122275228 @default.
• W2052868904 cites W2125941855 @default.
• W2052868904 cites W2126678086 @default.
• W2052868904 cites W2129714806 @default.
• W2052868904 cites W2138684334 @default.
• W2052868904 cites W2140118041 @default.
• W2052868904 cites W2147921405 @default.
• W2052868904 cites W2152001406 @default.
• W2052868904 cites W2153023449 @default.
• W2052868904 cites W2153092306 @default.
• W2052868904 cites W2158797202 @default.
• W2052868904 cites W2158958374 @default.
• W2052868904 cites W2164069152 @default.
• W2052868904 cites W2170247979 @default.
• W2052868904 cites W2175029576 @default.
• W2052868904 cites W2288500425 @default.
• W2052868904 cites W2424607300 @default.
• W2052868904 doi "https://doi.org/10.1186/1471-2180-7-102" @default.
• W2052868904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3126692" @default.
• W2052868904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18034886" @default.
• W2052868904 hasPublicationYear "2007" @default.
• W2052868904 type Work @default.
• W2052868904 sameAs 2052868904 @default.
• W2052868904 citedByCount "30" @default.
• W2052868904 countsByYear W20528689042012 @default.
• W2052868904 countsByYear W20528689042013 @default.
• W2052868904 countsByYear W20528689042014 @default.
• W2052868904 countsByYear W20528689042015 @default.
• W2052868904 countsByYear W20528689042018 @default.
• W2052868904 countsByYear W20528689042023 @default.
• W2052868904 crossrefType "journal-article" @default.
• W2052868904 hasAuthorship W2052868904A5002608068 @default.
• W2052868904 hasAuthorship W2052868904A5043654759 @default.
• W2052868904 hasAuthorship W2052868904A5045762902 @default.
• W2052868904 hasAuthorship W2052868904A5051242188 @default.
• W2052868904 hasAuthorship W2052868904A5055299602 @default.
• W2052868904 hasAuthorship W2052868904A5060145424 @default.
• W2052868904 hasAuthorship W2052868904A5063759119 @default.
• W2052868904 hasAuthorship W2052868904A5074781696 @default.
• W2052868904 hasAuthorship W2052868904A5077794725 @default.
• W2052868904 hasAuthorship W2052868904A5083666893 @default.
• W2052868904 hasAuthorship W2052868904A5088695508 @default.
• W2052868904 hasBestOaLocation W20528689041 @default.
• W2052868904 hasConcept C104317684 @default.
• W2052868904 hasConcept C153911025 @default.
• W2052868904 hasConcept C203014093 @default.
• W2052868904 hasConcept C2776118409 @default.
• W2052868904 hasConcept C2777730290 @default.
• W2052868904 hasConcept C2778690821 @default.
• W2052868904 hasConcept C38117629 @default.
• W2052868904 hasConcept C49039625 @default.
• W2052868904 hasConcept C523546767 @default.
• W2052868904 hasConcept C54355233 @default.

• next