Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052870901> ?p ?o ?g. }
- W2052870901 abstract "Astrocytic network alterations have been reported in Alzheimer's disease (AD), but the underlying pathways have remained undefined. Here we measure astrocytic calcium, cerebral blood flow and amyloid-β plaques in vivo in a mouse model of AD using multiphoton microscopy. We find that astrocytic hyperactivity, consisting of single-cell transients and calcium waves, is most pronounced in reactive astrogliosis around plaques and is sometimes associated with local blood flow changes. We show that astroglial hyperactivity is reduced after P2 purinoreceptor blockade or nucleotide release through connexin hemichannels, but is augmented by increasing cortical ADP concentration. P2X receptor blockade has no effect, but inhibition of P2Y1 receptors, which are strongly expressed by reactive astrocytes surrounding plaques, completely normalizes astrocytic hyperactivity. Our data suggest that astroglial network dysfunction is mediated by purinergic signalling in reactive astrocytes, and that intervention aimed at P2Y1 receptors or hemichannel-mediated nucleotide release may help ameliorate network dysfunction in AD." @default.
- W2052870901 created "2016-06-24" @default.
- W2052870901 creator A5003056966 @default.
- W2052870901 creator A5010854666 @default.
- W2052870901 creator A5020375796 @default.
- W2052870901 creator A5024592497 @default.
- W2052870901 creator A5060152877 @default.
- W2052870901 creator A5088345690 @default.
- W2052870901 date "2014-11-19" @default.
- W2052870901 modified "2023-10-16" @default.
- W2052870901 title "Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model" @default.
- W2052870901 cites W1508697366 @default.
- W2052870901 cites W1571332834 @default.
- W2052870901 cites W1965276722 @default.
- W2052870901 cites W1967903500 @default.
- W2052870901 cites W1970481007 @default.
- W2052870901 cites W1978836458 @default.
- W2052870901 cites W1980610697 @default.
- W2052870901 cites W1980825524 @default.
- W2052870901 cites W1984295722 @default.
- W2052870901 cites W1989149160 @default.
- W2052870901 cites W1997301424 @default.
- W2052870901 cites W1998432972 @default.
- W2052870901 cites W2005970127 @default.
- W2052870901 cites W2006035554 @default.
- W2052870901 cites W2010046691 @default.
- W2052870901 cites W2011331227 @default.
- W2052870901 cites W2023200476 @default.
- W2052870901 cites W2026154459 @default.
- W2052870901 cites W2027143592 @default.
- W2052870901 cites W2027430739 @default.
- W2052870901 cites W2027616725 @default.
- W2052870901 cites W2027997017 @default.
- W2052870901 cites W2032770343 @default.
- W2052870901 cites W2033286591 @default.
- W2052870901 cites W2034854389 @default.
- W2052870901 cites W2035466313 @default.
- W2052870901 cites W2036146605 @default.
- W2052870901 cites W2040490831 @default.
- W2052870901 cites W2042977369 @default.
- W2052870901 cites W2048685634 @default.
- W2052870901 cites W2057505611 @default.
- W2052870901 cites W2058288195 @default.
- W2052870901 cites W2065349788 @default.
- W2052870901 cites W2067102106 @default.
- W2052870901 cites W2068624858 @default.
- W2052870901 cites W2071640894 @default.
- W2052870901 cites W2076316745 @default.
- W2052870901 cites W2077180002 @default.
- W2052870901 cites W2085424855 @default.
- W2052870901 cites W2086157231 @default.
- W2052870901 cites W2086655442 @default.
- W2052870901 cites W2087575468 @default.
- W2052870901 cites W2093352806 @default.
- W2052870901 cites W2093606296 @default.
- W2052870901 cites W2106902340 @default.
- W2052870901 cites W2108391104 @default.
- W2052870901 cites W2114217860 @default.
- W2052870901 cites W2119835056 @default.
- W2052870901 cites W2122318491 @default.
- W2052870901 cites W2122828560 @default.
- W2052870901 cites W2124127229 @default.
- W2052870901 cites W2124658196 @default.
- W2052870901 cites W2129977027 @default.
- W2052870901 cites W2131180711 @default.
- W2052870901 cites W2134494361 @default.
- W2052870901 cites W2135328571 @default.
- W2052870901 cites W2136095861 @default.
- W2052870901 cites W2139409826 @default.
- W2052870901 cites W2139521371 @default.
- W2052870901 cites W2140616438 @default.
- W2052870901 cites W2143882188 @default.
- W2052870901 cites W2150820507 @default.
- W2052870901 cites W2156346381 @default.
- W2052870901 cites W2156788921 @default.
- W2052870901 cites W2163755116 @default.
- W2052870901 cites W2167670991 @default.
- W2052870901 cites W2411086663 @default.
- W2052870901 cites W274427711 @default.
- W2052870901 doi "https://doi.org/10.1038/ncomms6422" @default.
- W2052870901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25406732" @default.
- W2052870901 hasPublicationYear "2014" @default.
- W2052870901 type Work @default.
- W2052870901 sameAs 2052870901 @default.
- W2052870901 citedByCount "223" @default.
- W2052870901 countsByYear W20528709012015 @default.
- W2052870901 countsByYear W20528709012016 @default.
- W2052870901 countsByYear W20528709012017 @default.
- W2052870901 countsByYear W20528709012018 @default.
- W2052870901 countsByYear W20528709012019 @default.
- W2052870901 countsByYear W20528709012020 @default.
- W2052870901 countsByYear W20528709012021 @default.
- W2052870901 countsByYear W20528709012022 @default.
- W2052870901 countsByYear W20528709012023 @default.
- W2052870901 crossrefType "journal-article" @default.
- W2052870901 hasAuthorship W2052870901A5003056966 @default.
- W2052870901 hasAuthorship W2052870901A5010854666 @default.
- W2052870901 hasAuthorship W2052870901A5020375796 @default.
- W2052870901 hasAuthorship W2052870901A5024592497 @default.
- W2052870901 hasAuthorship W2052870901A5060152877 @default.