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- W2052871573 abstract "In isolated rat hepatocytes phenylephrine promotes a rapid increase in the amount of pyruvate dehydrogenase present in its active form (PDH a ). This action is mediated by α 1 ‐adrenergic receptors and is not observed in Ca 2+ ‐depleted hepatocytes. It is mimicked by the Ca 2+ ionophore A23187. No changes in metabolites known to affect PDH activity are measured 3 min after addition of phenylephrine. Glucagon also increases PDH a , its action is additive to that of phenylephrine. The action of phenylephrine on PDH a could be explained by an increase in mitochondrial free Ca 2+ ." @default.
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- W2052871573 date "1983-08-08" @default.
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- W2052871573 title "Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon" @default.
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- W2052871573 doi "https://doi.org/10.1016/0014-5793(83)80421-9" @default.
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