FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052873380> ?p ?o ?g. }

• W2052873380 endingPage "489" @default.
• W2052873380 startingPage "469" @default.
• W2052873380 abstract "The brain originates relatively early in development from differentiated ectoderm that forms a hollow tube and takes on an exceedingly complex shape with development. The skull is made up of individual bony elements that form from neural crest- and mesoderm-derived mesenchyme that unite to provide support and protection for soft tissues and spaces of the head. The meninges provide a protective and permeable membrane between brain and skull. Across evolutionary and developmental time, dynamic changes in brain and skull shape track one another so that their integration is evidenced in two structures that fit soundly regardless of changes in biomechanical and physiologic functions. Evidence for this tight correspondence is also seen in diseases of the craniofacial complex that are often classified as diseases of the skull (e.g., craniosynostosis) or diseases of the brain (e.g., holoprosencephaly) even when both tissues are affected. Our review suggests a model that links brain and skull morphogenesis through coordinated integration of signaling pathways (e.g., FGF, TGFβ, Wnt) via processes that are not currently understood, perhaps involving the meninges. Differences in the earliest signaling of biological structure establish divergent designs that will be enhanced during morphogenesis. Signaling systems that pattern the developing brain are also active in patterning required for growth and assembly of the skull and some members of these signaling families have been indicated as causal for craniofacial diseases. Because cells of early brain and skull are sensitive to similar signaling families, variation in the strength or timing of signals or shifts in patterning boundaries that affect one system (neural or skull) could also affect the other system and appropriate co-adjustments in development would be made. Interactions of these signaling systems and of the tissues that they pattern are fundamental to the consistent but labile functional and structural association of brain and skull conserved over evolutionary time obvious in the study of development and disease." @default.
• W2052873380 created "2016-06-24" @default.
• W2052873380 creator A5015648857 @default.
• W2052873380 creator A5044816186 @default.
• W2052873380 date "2013-03-23" @default.
• W2052873380 modified "2023-10-10" @default.
• W2052873380 title "Hand in glove: brain and skull in development and dysmorphogenesis" @default.
• W2052873380 cites W1445133092 @default.
• W2052873380 cites W1546479867 @default.
• W2052873380 cites W1571399449 @default.
• W2052873380 cites W1607201914 @default.
• W2052873380 cites W1835943580 @default.
• W2052873380 cites W1872948815 @default.
• W2052873380 cites W1913246601 @default.
• W2052873380 cites W1963756782 @default.
• W2052873380 cites W1963985949 @default.
• W2052873380 cites W1964264655 @default.
• W2052873380 cites W1965963850 @default.
• W2052873380 cites W1968506415 @default.
• W2052873380 cites W1969654878 @default.
• W2052873380 cites W1969673950 @default.
• W2052873380 cites W1973581994 @default.
• W2052873380 cites W1974014442 @default.
• W2052873380 cites W1974199463 @default.
• W2052873380 cites W1977144442 @default.
• W2052873380 cites W1977300801 @default.
• W2052873380 cites W1979178399 @default.
• W2052873380 cites W1983077668 @default.
• W2052873380 cites W1984699863 @default.
• W2052873380 cites W1984758838 @default.
• W2052873380 cites W1985716862 @default.
• W2052873380 cites W1988476050 @default.
• W2052873380 cites W1989045574 @default.
• W2052873380 cites W1990214734 @default.
• W2052873380 cites W1992118483 @default.
• W2052873380 cites W1993163869 @default.
• W2052873380 cites W1995417183 @default.
• W2052873380 cites W1996258914 @default.
• W2052873380 cites W1997035797 @default.
• W2052873380 cites W1999322873 @default.
• W2052873380 cites W2000948047 @default.
• W2052873380 cites W2001237524 @default.
• W2052873380 cites W2001584235 @default.
• W2052873380 cites W2003198145 @default.
• W2052873380 cites W2003536083 @default.
• W2052873380 cites W2003903011 @default.
• W2052873380 cites W2004186396 @default.
• W2052873380 cites W2009425793 @default.
• W2052873380 cites W2009951097 @default.
• W2052873380 cites W2010843037 @default.
• W2052873380 cites W2011975727 @default.
• W2052873380 cites W2012498641 @default.
• W2052873380 cites W2012989050 @default.
• W2052873380 cites W2013204587 @default.
• W2052873380 cites W2013401347 @default.
• W2052873380 cites W2018309296 @default.
• W2052873380 cites W2018487851 @default.
• W2052873380 cites W2026118162 @default.
• W2052873380 cites W2026201824 @default.
• W2052873380 cites W2027942870 @default.
• W2052873380 cites W2032394856 @default.
• W2052873380 cites W2033267857 @default.
• W2052873380 cites W2034885934 @default.
• W2052873380 cites W2036320825 @default.
• W2052873380 cites W2037486322 @default.
• W2052873380 cites W2037499635 @default.
• W2052873380 cites W2037815161 @default.
• W2052873380 cites W2038675898 @default.
• W2052873380 cites W2040916923 @default.
• W2052873380 cites W2042545863 @default.
• W2052873380 cites W2042932723 @default.
• W2052873380 cites W2045065892 @default.
• W2052873380 cites W2045497152 @default.
• W2052873380 cites W2047201102 @default.
• W2052873380 cites W2047405437 @default.
• W2052873380 cites W2049254268 @default.
• W2052873380 cites W2050132916 @default.
• W2052873380 cites W2054151200 @default.
• W2052873380 cites W2056434612 @default.
• W2052873380 cites W2056983875 @default.
• W2052873380 cites W2059413013 @default.
• W2052873380 cites W2059793534 @default.
• W2052873380 cites W2060136095 @default.
• W2052873380 cites W2061191160 @default.
• W2052873380 cites W2066715151 @default.
• W2052873380 cites W2068208801 @default.
• W2052873380 cites W2068469125 @default.
• W2052873380 cites W2074472367 @default.
• W2052873380 cites W2078435464 @default.
• W2052873380 cites W2081554709 @default.
• W2052873380 cites W2082600118 @default.
• W2052873380 cites W2085657752 @default.
• W2052873380 cites W2089505724 @default.
• W2052873380 cites W2091212411 @default.
• W2052873380 cites W2091513271 @default.
• W2052873380 cites W2092472216 @default.
• W2052873380 cites W2093291689 @default.
• W2052873380 cites W2093831365 @default.

• next