Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052879590> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2052879590 endingPage "84" @default.
- W2052879590 startingPage "83" @default.
- W2052879590 abstract "Possible differentiation of the intervention of cholinergic septohippocampal and magnocellular forebrain (NBM) projections to cortex during learning and memory processes has been investigated directly using mice. High-affinity choline uptake velocities in the hippocampus and cortex were analyzed, in parallel, at various periods during the acquisition, over 8 days, as were the subsequent retention, reversal and extinction of a spatial discrimination in an 8-arm radial maze. Initial acquisition induced an immediate (30 s) and long-lasting (approx. 3 h) increase in mean hippocampal (+ 33%) and cortical (+ 23%) cholinergic activities. The time course of this activation was structure-dependent and correlations of hippocampal-cortical cholinergic activities showed large and consistent alterations as a function of time after training. Cholinergic activation in both brain regions was observed immediately following each daily training session with amplitudes which did not vary significantly in spite of a progressive daily increment in performance. Following acquisition mice were tested for retention, reversal and extinction: 30 s following the retention session, cholinergic activation was observed in both cortex and hippocampus, with magnitudes similar to those observed at the end of acquisition. However, in the reversal and extinction groups, a treatment-dependent attenuation of cholinergic activation was observed which was accompanied by a significant loss of correlation of cholinergic activity between these two brain regions. The results are discussed in relation to the concepts of reference and working memory and also to novelty, stress, arousal and frustrative non-reward. The data constitute direct experimental evidence for a differential involvement of cholinergic septohippocampal and NBM-cortical projections in learning and memory processes." @default.
- W2052879590 created "2016-06-24" @default.
- W2052879590 creator A5021668008 @default.
- W2052879590 creator A5030702963 @default.
- W2052879590 creator A5054379081 @default.
- W2052879590 date "1986-04-01" @default.
- W2052879590 modified "2023-10-14" @default.
- W2052879590 title "Some behavioural effects of non-reward in an 8-arm radial maze" @default.
- W2052879590 doi "https://doi.org/10.1016/0166-4328(86)90128-2" @default.
- W2052879590 hasPublicationYear "1986" @default.
- W2052879590 type Work @default.
- W2052879590 sameAs 2052879590 @default.
- W2052879590 citedByCount "1" @default.
- W2052879590 crossrefType "journal-article" @default.
- W2052879590 hasAuthorship W2052879590A5021668008 @default.
- W2052879590 hasAuthorship W2052879590A5030702963 @default.
- W2052879590 hasAuthorship W2052879590A5054379081 @default.
- W2052879590 hasConcept C101991246 @default.
- W2052879590 hasConcept C104966671 @default.
- W2052879590 hasConcept C148762608 @default.
- W2052879590 hasConcept C15744967 @default.
- W2052879590 hasConcept C169760540 @default.
- W2052879590 hasConcept C185592680 @default.
- W2052879590 hasConcept C199289684 @default.
- W2052879590 hasConcept C22885893 @default.
- W2052879590 hasConcept C2777348757 @default.
- W2052879590 hasConcept C2781161787 @default.
- W2052879590 hasConceptScore W2052879590C101991246 @default.
- W2052879590 hasConceptScore W2052879590C104966671 @default.
- W2052879590 hasConceptScore W2052879590C148762608 @default.
- W2052879590 hasConceptScore W2052879590C15744967 @default.
- W2052879590 hasConceptScore W2052879590C169760540 @default.
- W2052879590 hasConceptScore W2052879590C185592680 @default.
- W2052879590 hasConceptScore W2052879590C199289684 @default.
- W2052879590 hasConceptScore W2052879590C22885893 @default.
- W2052879590 hasConceptScore W2052879590C2777348757 @default.
- W2052879590 hasConceptScore W2052879590C2781161787 @default.
- W2052879590 hasIssue "1" @default.
- W2052879590 hasLocation W20528795901 @default.
- W2052879590 hasOpenAccess W2052879590 @default.
- W2052879590 hasPrimaryLocation W20528795901 @default.
- W2052879590 hasRelatedWork W1985759952 @default.
- W2052879590 hasRelatedWork W2005260297 @default.
- W2052879590 hasRelatedWork W2014153425 @default.
- W2052879590 hasRelatedWork W2024626940 @default.
- W2052879590 hasRelatedWork W2069958148 @default.
- W2052879590 hasRelatedWork W2273632874 @default.
- W2052879590 hasRelatedWork W2775969270 @default.
- W2052879590 hasRelatedWork W2890197740 @default.
- W2052879590 hasRelatedWork W3014139862 @default.
- W2052879590 hasRelatedWork W4315629514 @default.
- W2052879590 hasVolume "20" @default.
- W2052879590 isParatext "false" @default.
- W2052879590 isRetracted "false" @default.
- W2052879590 magId "2052879590" @default.
- W2052879590 workType "article" @default.