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• W2052893104 abstract "The goal was to characterize differences in cell response after exposure to active beam scanning (ABS) protons compared to a passive delivery system. Human lung epithelial (HLE) cells were evaluated at various locations along the proton depth dose profile. The dose delivered at the Bragg peak position was essentially identical (∼4 Gy) with the two techniques, but depth dose data showed that ABS resulted in lower doses at entry and more rapid drop-off after the peak. Average dose rates for the passive and ABS beams were 1.1 Gy/min and 5.1 Gy/min, respectively; instantaneous dose rates were 19.2 Gy/min and 2,300 Gy/min (to a 0.5 × 0.5 mm 2 voxel). Analysis of DNA synthesis was based on 3 H-TdR incorporation. Quantitative real-time polymerase chain reaction (RT-PCR) was done to determine expression of genes related to p53 signaling and DNA damage; a total of 152 genes were assessed. Spectral karyotyping and analyses of the Golgi apparatus and cytokines produced by the HLE cells were also performed. At or near the Bragg peak position, ABS protons resulted in a greater decrease in DNA synthesis compared to passively delivered protons. Genes with >2-fold change (P < 0.05 vs. 0 Gy) after passive proton irradiation at one or more locations within the Bragg curve were BTG2, CDKN1A, IFNB1 and SIAH1. In contrast, many more genes had >2-fold difference with ABS protons: BRCA1, BRCA2, CDC25A, CDC25C, CCNB2, CDK1, DMC1, DNMT1, E2F1, EXO1, FEN1, GADD45A, GTSE1, IL-6, JUN, KRAS, MDM4, PRC1, PTTG1, RAD51, RPA1, TNF, WT1, XRCC2, XRCC3 and XRCC6BP1. Spectral karyotyping revealed numerous differences in chromosomal abnormalities between the two delivery systems, especially at or near the Bragg peak. Percentage of cells staining for the Golgi apparatus was low after exposure to passive and active proton beams. Studies such as this are needed to ensure patient safety and make modifications in ABS delivery, if necessary." @default.
• W2052893104 created "2016-06-24" @default.
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• W2052893104 date "2015-02-01" @default.
• W2052893104 modified "2023-09-26" @default.
• W2052893104 title "Biological Effects of Passive Versus Active Scanning Proton Beams on Human Lung Epithelial Cells" @default.
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• W2052893104 cites W1967010451 @default.
• W2052893104 cites W1969093811 @default.
• W2052893104 cites W1969688503 @default.
• W2052893104 cites W1971044020 @default.
• W2052893104 cites W1976444850 @default.
• W2052893104 cites W1978104377 @default.
• W2052893104 cites W1979814743 @default.
• W2052893104 cites W1986501312 @default.
• W2052893104 cites W1988376832 @default.
• W2052893104 cites W1990050702 @default.
• W2052893104 cites W1994000794 @default.
• W2052893104 cites W1997324813 @default.
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• W2052893104 cites W2021819143 @default.
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• W2052893104 doi "https://doi.org/10.7785/tcrt.2012.500392" @default.
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