FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052894530> ?p ?o ?g. }

• W2052894530 endingPage "362" @default.
• W2052894530 startingPage "353" @default.
• W2052894530 abstract "The mechanisms underlying the conversion of prolonged glutamate release from ribbon synapses in bipolar cells to sustained and transient excitatory postsynaptic responses in identified retinal amacrine cells were studied in tiger salamander (Ambystoma tigrinum) retina. A retina slice preparation with whole cell patch recording techniques under voltage- and current-clamp conditions was used to assay the electrical properties of bipolar and amacrine cells. Amacrine cells were categorized into two basic forms: (i) transient amacrine cells that respond to a step of light with a burst of spikes only at the transitions of the step; and (ii) sustained amacrine cells that respond with continuous spiking during the entire light step. The two cell types each had a characteristic morphology: transient amacrine cells possessed wide dendritic fields (chi = 375 microns), while sustained cells had much more narrowly confined dendritic fields (chi = 85 microns). Whole cell voltage-gated currents of the transient and sustained cell types were not significantly different. Both cell types had spikes that were sensitive to tetradotoxin (TTX, 0.3 microM) with voltage deflections of up to 100 mV. Light-evoked excitatory synaptic currents relaxed rapidly in transient neurons (tau 1/2 = 100 ms) and more slowly in sustained neurons (tau 1/2 = 1.2 s). EPSCs in both cells reversed near 0 mV. Rapid application of glutamate or kainate elicited rapidly desensitizing ionic currents (tau 1/2 = 85 ms) followed by a slowly desensitizing component. Cyclothiazide, a drug that eliminates rapid desensitization, lengthened the time course of the glutamate gated current from tau 1/2 = 85 ms to about 3 s, and the relaxation kinetics of the glutamatergic EPSC from tau 1/2 = 85 ms to about 1.0 s. These data suggest that a key determinant in forming transient versus sustained responses in amacrine cells of vertebrate retina is the differences in their excitatory, glutamatergic synaptic inputs, and that rapid desensitization of glutamate receptors plays a role in converting the presynaptic signal associated with sustained glutamate release into a postsynaptic, transient signal at the ribbon synapse." @default.
• W2052894530 created "2016-06-24" @default.
• W2052894530 creator A5044375589 @default.
• W2052894530 date "1999-01-01" @default.
• W2052894530 modified "2023-10-04" @default.
• W2052894530 title "Rapid desensitization converts prolonged glutamate release into a transient EPSC at ribbon synapses between retinal bipolar and amacrine cells" @default.
• W2052894530 cites W1520518927 @default.
• W2052894530 cites W1541733950 @default.
• W2052894530 cites W1610621213 @default.
• W2052894530 cites W1817006636 @default.
• W2052894530 cites W1872667629 @default.
• W2052894530 cites W1875904161 @default.
• W2052894530 cites W1965504075 @default.
• W2052894530 cites W1976680575 @default.
• W2052894530 cites W1977451474 @default.
• W2052894530 cites W1977529115 @default.
• W2052894530 cites W1978054401 @default.
• W2052894530 cites W1981837661 @default.
• W2052894530 cites W1982662582 @default.
• W2052894530 cites W1983113602 @default.
• W2052894530 cites W1990220309 @default.
• W2052894530 cites W1999076238 @default.
• W2052894530 cites W1999208340 @default.
• W2052894530 cites W2003059369 @default.
• W2052894530 cites W2008143740 @default.
• W2052894530 cites W2009667219 @default.
• W2052894530 cites W2014039492 @default.
• W2052894530 cites W2016415553 @default.
• W2052894530 cites W2022046189 @default.
• W2052894530 cites W2022545692 @default.
• W2052894530 cites W2026377076 @default.
• W2052894530 cites W2026559607 @default.
• W2052894530 cites W2033352936 @default.
• W2052894530 cites W2036453841 @default.
• W2052894530 cites W2036616538 @default.
• W2052894530 cites W2038678229 @default.
• W2052894530 cites W2045171292 @default.
• W2052894530 cites W2048381454 @default.
• W2052894530 cites W2048755709 @default.
• W2052894530 cites W2051382273 @default.
• W2052894530 cites W2058439409 @default.
• W2052894530 cites W2062668710 @default.
• W2052894530 cites W2067438800 @default.
• W2052894530 cites W2074688705 @default.
• W2052894530 cites W2076883859 @default.
• W2052894530 cites W2084959064 @default.
• W2052894530 cites W2085511256 @default.
• W2052894530 cites W2088880312 @default.
• W2052894530 cites W2090476414 @default.
• W2052894530 cites W2102186263 @default.
• W2052894530 cites W2104228780 @default.
• W2052894530 cites W2108741524 @default.
• W2052894530 cites W2111369596 @default.
• W2052894530 cites W2120342366 @default.
• W2052894530 cites W2123714832 @default.
• W2052894530 cites W2128806021 @default.
• W2052894530 cites W2129899041 @default.
• W2052894530 cites W2137841465 @default.
• W2052894530 cites W2142715867 @default.
• W2052894530 cites W2143862724 @default.
• W2052894530 cites W2172552212 @default.
• W2052894530 cites W2410813315 @default.
• W2052894530 cites W2462519978 @default.
• W2052894530 doi "https://doi.org/10.1046/j.1460-9568.1999.00439.x" @default.
• W2052894530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9987038" @default.
• W2052894530 hasPublicationYear "1999" @default.
• W2052894530 type Work @default.
• W2052894530 sameAs 2052894530 @default.
• W2052894530 citedByCount "12" @default.
• W2052894530 countsByYear W20528945302015 @default.
• W2052894530 countsByYear W20528945302017 @default.
• W2052894530 crossrefType "journal-article" @default.
• W2052894530 hasAuthorship W2052894530A5044375589 @default.
• W2052894530 hasConcept C112592302 @default.
• W2052894530 hasConcept C12554922 @default.
• W2052894530 hasConcept C130316041 @default.
• W2052894530 hasConcept C147944092 @default.
• W2052894530 hasConcept C148785051 @default.
• W2052894530 hasConcept C160268369 @default.
• W2052894530 hasConcept C169760540 @default.
• W2052894530 hasConcept C170493617 @default.
• W2052894530 hasConcept C17077164 @default.
• W2052894530 hasConcept C185263204 @default.
• W2052894530 hasConcept C185592680 @default.
• W2052894530 hasConcept C189184402 @default.
• W2052894530 hasConcept C197341189 @default.
• W2052894530 hasConcept C2777093970 @default.
• W2052894530 hasConcept C2778658801 @default.
• W2052894530 hasConcept C2910581834 @default.
• W2052894530 hasConcept C38120836 @default.
• W2052894530 hasConcept C41625074 @default.
• W2052894530 hasConcept C55493867 @default.
• W2052894530 hasConcept C61174792 @default.
• W2052894530 hasConcept C86803240 @default.
• W2052894530 hasConceptScore W2052894530C112592302 @default.
• W2052894530 hasConceptScore W2052894530C12554922 @default.
• W2052894530 hasConceptScore W2052894530C130316041 @default.
• W2052894530 hasConceptScore W2052894530C147944092 @default.

• next