Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052897619> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2052897619 endingPage "74" @default.
- W2052897619 startingPage "70" @default.
- W2052897619 abstract "The vaginal mucosa is the most common site of infection for viruses that are transmitted through heterosexual intercourse, including human immunodeficiency virus and papillomavirus. Thus, in order to prevent or respond to these infections, strong vaginal immunity is required as the first line of defense. We previously investigated the use of a needle-free injector as a mucosal vaccination tool in rabbits and demonstrated that this is a promising method for stimulating vaginal gene expression and immune responses. In order to improve gene expression, we have examined local vaginal gene transfection efficiency using a non-needle jet injector combined with an effective peptide carrier in rabbits. The carrier used was a stearoyl (STR) peptide with Cys (C), Arg (R) and His (H) residues that form disulfide cross linkages via Cys (STR-CH2R4H2C) which was developed in our previous study. As a result, vaginal gene expression using the needle-free injector combined with STR-CH2R4H2C carrier was significantly improved compared to that without STR-CH2R4H2C carrier. Moreover, intravaginal pDNA vaccination by the needle-free injector combined with STR-CH2R4H2C carrier and CpG-ODN promoted not only local vaginal IgA and IgG, but also serum IgG secretion, to a degree significantly higher than that of naked pDNA." @default.
- W2052897619 created "2016-06-24" @default.
- W2052897619 creator A5001867431 @default.
- W2052897619 creator A5015048930 @default.
- W2052897619 creator A5035840491 @default.
- W2052897619 creator A5054328523 @default.
- W2052897619 creator A5069857354 @default.
- W2052897619 date "2013-04-01" @default.
- W2052897619 modified "2023-09-24" @default.
- W2052897619 title "Needle-free intravaginal DNA vaccination using a stearoyl oligopeptide carrier promotes local gene expression and immune responses" @default.
- W2052897619 cites W1517377066 @default.
- W2052897619 cites W1987736203 @default.
- W2052897619 cites W2011362104 @default.
- W2052897619 cites W2054580307 @default.
- W2052897619 cites W2055802294 @default.
- W2052897619 cites W2058395594 @default.
- W2052897619 cites W2065157516 @default.
- W2052897619 cites W2077748966 @default.
- W2052897619 cites W2082368328 @default.
- W2052897619 cites W2095922293 @default.
- W2052897619 cites W2163704623 @default.
- W2052897619 cites W2170553767 @default.
- W2052897619 cites W2320852660 @default.
- W2052897619 doi "https://doi.org/10.1016/j.ijpharm.2013.02.018" @default.
- W2052897619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23454850" @default.
- W2052897619 hasPublicationYear "2013" @default.
- W2052897619 type Work @default.
- W2052897619 sameAs 2052897619 @default.
- W2052897619 citedByCount "15" @default.
- W2052897619 countsByYear W20528976192014 @default.
- W2052897619 countsByYear W20528976192015 @default.
- W2052897619 countsByYear W20528976192016 @default.
- W2052897619 countsByYear W20528976192020 @default.
- W2052897619 countsByYear W20528976192021 @default.
- W2052897619 countsByYear W20528976192022 @default.
- W2052897619 crossrefType "journal-article" @default.
- W2052897619 hasAuthorship W2052897619A5001867431 @default.
- W2052897619 hasAuthorship W2052897619A5015048930 @default.
- W2052897619 hasAuthorship W2052897619A5035840491 @default.
- W2052897619 hasAuthorship W2052897619A5054328523 @default.
- W2052897619 hasAuthorship W2052897619A5069857354 @default.
- W2052897619 hasConcept C104317684 @default.
- W2052897619 hasConcept C150194340 @default.
- W2052897619 hasConcept C159047783 @default.
- W2052897619 hasConcept C167508917 @default.
- W2052897619 hasConcept C203014093 @default.
- W2052897619 hasConcept C22070199 @default.
- W2052897619 hasConcept C2777744392 @default.
- W2052897619 hasConcept C2780801004 @default.
- W2052897619 hasConcept C54009773 @default.
- W2052897619 hasConcept C54355233 @default.
- W2052897619 hasConcept C86803240 @default.
- W2052897619 hasConcept C8891405 @default.
- W2052897619 hasConceptScore W2052897619C104317684 @default.
- W2052897619 hasConceptScore W2052897619C150194340 @default.
- W2052897619 hasConceptScore W2052897619C159047783 @default.
- W2052897619 hasConceptScore W2052897619C167508917 @default.
- W2052897619 hasConceptScore W2052897619C203014093 @default.
- W2052897619 hasConceptScore W2052897619C22070199 @default.
- W2052897619 hasConceptScore W2052897619C2777744392 @default.
- W2052897619 hasConceptScore W2052897619C2780801004 @default.
- W2052897619 hasConceptScore W2052897619C54009773 @default.
- W2052897619 hasConceptScore W2052897619C54355233 @default.
- W2052897619 hasConceptScore W2052897619C86803240 @default.
- W2052897619 hasConceptScore W2052897619C8891405 @default.
- W2052897619 hasFunder F4320327572 @default.
- W2052897619 hasIssue "1-2" @default.
- W2052897619 hasLocation W20528976191 @default.
- W2052897619 hasLocation W20528976192 @default.
- W2052897619 hasOpenAccess W2052897619 @default.
- W2052897619 hasPrimaryLocation W20528976191 @default.
- W2052897619 hasRelatedWork W155301942 @default.
- W2052897619 hasRelatedWork W1992291388 @default.
- W2052897619 hasRelatedWork W2009966535 @default.
- W2052897619 hasRelatedWork W2011774237 @default.
- W2052897619 hasRelatedWork W2019574320 @default.
- W2052897619 hasRelatedWork W2086695199 @default.
- W2052897619 hasRelatedWork W2143941734 @default.
- W2052897619 hasRelatedWork W3193012584 @default.
- W2052897619 hasRelatedWork W4206914007 @default.
- W2052897619 hasRelatedWork W4221063257 @default.
- W2052897619 hasVolume "447" @default.
- W2052897619 isParatext "false" @default.
- W2052897619 isRetracted "false" @default.
- W2052897619 magId "2052897619" @default.
- W2052897619 workType "article" @default.