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• W2052900156 abstract "<h2>Abstract</h2> Cell-free supernatant from formylmethionyl-leucyl-phenylalanine (fMLP)-activated granulocytes causes a time- and concentration-dependent stimulation of prostaglandin E₂ (PGE₂) production in amnion cells. PGE₂ concentration in the culture medium after 36 h treatment with granulocyte supernatant (from 40 × 10⁶ granulocytes/ml of amnion cell medium), 1.49 ± 0.71 pg/ng DNA (n = 13), was significantly higher (p = 0.0015) than in control cells (0.33 ± 0.23 pg/ng DNA, n=13). Indomethacin abolished this stimulation. Granulocyte supernatant and human epidermal growth factor (hEGF) had an additive effect on amnion cell PGE₂ production. Catalase, superoxide dismutase (SOD), protease inhibitors or the platelet-activating factor (PAF) antagonist L-659,989 had no effect. Actinomycin D, cycloheximide and mepacrine reduced the PGE₂ production. The phospholipase A₂ activity present in granulocyte supernatants was resistant to heating, whereas heating decreased their PGE₂-stimulating activity by 92%. Exogenous phospholipase A₂ had no effect on PGE₂ synthesis. The granulocyte product could be precipitated with ammonium sulphate. On gel filtration of supernatant, two peaks of PGE₂-synthesis stimulating activity were obtained (molecular weights 12 000 and 60 000). This data serve to explain the association of chorioamnionitis with preterm labor: activated granulocytes release a protein(s) that induces prostaglandin production in amnion cells, and thus promote labor." @default.
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• W2052900156 date "1991-05-01" @default.
• W2052900156 modified "2023-09-24" @default.
• W2052900156 title "A product of activated human granulocytes stimulates prostaglandin E2 synthesis in human amnion cells" @default.
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• W2052900156 doi "https://doi.org/10.1016/0952-3278(91)90130-w" @default.
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