Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052903852> ?p ?o ?g. }
- W2052903852 endingPage "31" @default.
- W2052903852 startingPage "20" @default.
- W2052903852 abstract "Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant modulation of several key HS biosynthetic enzymes such as 3-O Sulfotransferase and 6-O Sulfotransferase, and also catabolic enzymes such as HSulf-1, HSulf-2 and heparanase. The resulting tumor specific HS fine structures assist cancer cells to breakdown ECM to spread, misregulate signaling pathways to facilitate their proliferation, promote angiogenesis to receive nutrients, and protect themselves against natural killer cells. This review focuses on the changes in the expression of HS biosynthetic and catabolic enzymes in several cancers, the resulting changes in HS fine structures, and the effects of these tumor specific HS signatures on promoting invasion, proliferation, and metastasis. It is possible to retard tumor progression by modulating the deregulated biosynthetic and catabolic pathways of HS chains through novel chemical biology approaches." @default.
- W2052903852 created "2016-06-24" @default.
- W2052903852 creator A5011489319 @default.
- W2052903852 creator A5045982093 @default.
- W2052903852 date "2010-01-01" @default.
- W2052903852 modified "2023-10-09" @default.
- W2052903852 title "Chemical Tumor Biology of Heparan Sulfate Proteoglycans" @default.
- W2052903852 cites W1479797101 @default.
- W2052903852 cites W1491748226 @default.
- W2052903852 cites W1507411181 @default.
- W2052903852 cites W1510809099 @default.
- W2052903852 cites W1559400457 @default.
- W2052903852 cites W1578995377 @default.
- W2052903852 cites W1607350486 @default.
- W2052903852 cites W1622358858 @default.
- W2052903852 cites W1656339735 @default.
- W2052903852 cites W1811003963 @default.
- W2052903852 cites W1855999912 @default.
- W2052903852 cites W1882002483 @default.
- W2052903852 cites W1911803680 @default.
- W2052903852 cites W1915870046 @default.
- W2052903852 cites W1952042241 @default.
- W2052903852 cites W1955765029 @default.
- W2052903852 cites W1964130399 @default.
- W2052903852 cites W1965078663 @default.
- W2052903852 cites W1965599680 @default.
- W2052903852 cites W1966556597 @default.
- W2052903852 cites W1968744437 @default.
- W2052903852 cites W1969445939 @default.
- W2052903852 cites W1969834700 @default.
- W2052903852 cites W1970794228 @default.
- W2052903852 cites W1971892663 @default.
- W2052903852 cites W1972103333 @default.
- W2052903852 cites W1973711825 @default.
- W2052903852 cites W1973733841 @default.
- W2052903852 cites W1975510007 @default.
- W2052903852 cites W1977877980 @default.
- W2052903852 cites W1978347914 @default.
- W2052903852 cites W1978837916 @default.
- W2052903852 cites W1981822947 @default.
- W2052903852 cites W1982312174 @default.
- W2052903852 cites W1983713361 @default.
- W2052903852 cites W1983853385 @default.
- W2052903852 cites W1984710781 @default.
- W2052903852 cites W1984853905 @default.
- W2052903852 cites W1986366861 @default.
- W2052903852 cites W1986420866 @default.
- W2052903852 cites W1987556027 @default.
- W2052903852 cites W1987779442 @default.
- W2052903852 cites W1989676517 @default.
- W2052903852 cites W1989937317 @default.
- W2052903852 cites W1990306679 @default.
- W2052903852 cites W1990434285 @default.
- W2052903852 cites W1993490356 @default.
- W2052903852 cites W1994310530 @default.
- W2052903852 cites W1996514275 @default.
- W2052903852 cites W1997613697 @default.
- W2052903852 cites W1999951730 @default.
- W2052903852 cites W2000598899 @default.
- W2052903852 cites W2002071844 @default.
- W2052903852 cites W2004105893 @default.
- W2052903852 cites W2006323138 @default.
- W2052903852 cites W2007897263 @default.
- W2052903852 cites W2008581828 @default.
- W2052903852 cites W2010683995 @default.
- W2052903852 cites W2011830308 @default.
- W2052903852 cites W2012017699 @default.
- W2052903852 cites W2013200943 @default.
- W2052903852 cites W2013305106 @default.
- W2052903852 cites W2014463647 @default.
- W2052903852 cites W2015724236 @default.
- W2052903852 cites W2016050368 @default.
- W2052903852 cites W2016240486 @default.
- W2052903852 cites W2016254755 @default.
- W2052903852 cites W2016927165 @default.
- W2052903852 cites W2017430133 @default.
- W2052903852 cites W2019074842 @default.
- W2052903852 cites W2021036829 @default.
- W2052903852 cites W2022845014 @default.
- W2052903852 cites W2022906555 @default.
- W2052903852 cites W2027239974 @default.
- W2052903852 cites W2027825395 @default.
- W2052903852 cites W2028307231 @default.
- W2052903852 cites W2031583495 @default.
- W2052903852 cites W2033410380 @default.
- W2052903852 cites W2036944746 @default.
- W2052903852 cites W2041062187 @default.
- W2052903852 cites W2041091423 @default.
- W2052903852 cites W2041544027 @default.
- W2052903852 cites W2043605572 @default.
- W2052903852 cites W2044434159 @default.
- W2052903852 cites W2044563596 @default.
- W2052903852 cites W2045253560 @default.
- W2052903852 cites W2045468100 @default.
- W2052903852 cites W2047533646 @default.
- W2052903852 cites W2047649254 @default.
- W2052903852 cites W2050225501 @default.
- W2052903852 cites W2051005823 @default.