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- W2052910189 abstract "There are conflicting data with regard to the sensitivity of the human immune system to the toxic action of the highly toxic environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). SCID mice engrafted with human fetal thymus and liver tissue fragments (SCID-hu mice), which sustain normal human T cell differentiation in the thymus graft, were used to directly assess the sensitivity of the human thymus for TCDD. Wistar rats and SCID-hu mice were exposed to 1, 5, or 25 μg TCDD/kg body weight. Histopathologic effects were evaluated for rat thymus and transplanted human thymus on Day 4 after exposure. The relative size of the cortex showed a dose-dependent decrease in both the normal rat thymus and grafted human thymus (significant at 25 μg/kg). SCID-ra mice (SCID mice with a fetal rat thymus and liver graft) were used as an intermediate model between the normal rat and SCID-hu mice, and were exposed to the same dose levels of TCDD. However, 90% of the SCID-ra mice developed a cutaneous graft-versus-host reaction, associated with lymphodepletion of the rat thymus grafts, and hence a limited number of SCID-ra mice were available for evaluation of TCDD effects. The data obtained in SCID-ra mice were in line with those in normal rat and grafted human thymus. In gas chromatography/mass spectrometry analysis, TCDD tissue concentrations in the normal rat thymus and grafted human thymus were similar. We conclude that the human thymus serves as a target for TCDD, and that the human thymus and the Wistar rat thymus display a comparable sensitivity to the toxic action of TCDD." @default.
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- W2052910189 date "1995-10-01" @default.
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- W2052910189 title "Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to the Human Thymus After Implantation in SCID Mice" @default.
- W2052910189 doi "https://doi.org/10.1006/taap.1995.1195" @default.
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