Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052912081> ?p ?o ?g. }
- W2052912081 endingPage "1284" @default.
- W2052912081 startingPage "1281" @default.
- W2052912081 abstract "A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human melanoma. The mutated CDK4 allele was present in autologous cultured melanoma cells and metastasis tissue, but not in the patient's lymphocytes. The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide recognized by CTLs and prevented binding of the CDK4 inhibitor p16INK4a, but not of p21 or of p27KIP1. The same mutation was found in one additional melanoma among 28 melanomas analyzed. These results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a." @default.
- W2052912081 created "2016-06-24" @default.
- W2052912081 creator A5003394017 @default.
- W2052912081 creator A5003764731 @default.
- W2052912081 creator A5015774072 @default.
- W2052912081 creator A5017173229 @default.
- W2052912081 creator A5040719015 @default.
- W2052912081 creator A5045756025 @default.
- W2052912081 creator A5057916930 @default.
- W2052912081 creator A5061302501 @default.
- W2052912081 creator A5078985079 @default.
- W2052912081 creator A5087244560 @default.
- W2052912081 date "1995-09-01" @default.
- W2052912081 modified "2023-10-18" @default.
- W2052912081 title "A p16 <sup>INK4a</sup> -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma" @default.
- W2052912081 cites W1965517166 @default.
- W2052912081 cites W1967629365 @default.
- W2052912081 cites W1969057879 @default.
- W2052912081 cites W1971302107 @default.
- W2052912081 cites W1971512164 @default.
- W2052912081 cites W1977299280 @default.
- W2052912081 cites W1978146796 @default.
- W2052912081 cites W1983348452 @default.
- W2052912081 cites W1986267292 @default.
- W2052912081 cites W1989275979 @default.
- W2052912081 cites W1990925999 @default.
- W2052912081 cites W1994066190 @default.
- W2052912081 cites W1996413533 @default.
- W2052912081 cites W1997073961 @default.
- W2052912081 cites W2000734326 @default.
- W2052912081 cites W2003907692 @default.
- W2052912081 cites W200461798 @default.
- W2052912081 cites W2004920239 @default.
- W2052912081 cites W2007255413 @default.
- W2052912081 cites W2007772649 @default.
- W2052912081 cites W2008980266 @default.
- W2052912081 cites W2010493387 @default.
- W2052912081 cites W2015519364 @default.
- W2052912081 cites W2017689200 @default.
- W2052912081 cites W2020814485 @default.
- W2052912081 cites W2028878816 @default.
- W2052912081 cites W2035882662 @default.
- W2052912081 cites W2037218639 @default.
- W2052912081 cites W2040687166 @default.
- W2052912081 cites W2046577405 @default.
- W2052912081 cites W2049909641 @default.
- W2052912081 cites W2066848701 @default.
- W2052912081 cites W2067543077 @default.
- W2052912081 cites W2070854387 @default.
- W2052912081 cites W2081282586 @default.
- W2052912081 cites W2089218510 @default.
- W2052912081 cites W2092104789 @default.
- W2052912081 cites W2112086944 @default.
- W2052912081 cites W2114657480 @default.
- W2052912081 cites W2146600597 @default.
- W2052912081 cites W2147351677 @default.
- W2052912081 cites W2170889183 @default.
- W2052912081 cites W4294216491 @default.
- W2052912081 doi "https://doi.org/10.1126/science.7652577" @default.
- W2052912081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7652577" @default.
- W2052912081 hasPublicationYear "1995" @default.
- W2052912081 type Work @default.
- W2052912081 sameAs 2052912081 @default.
- W2052912081 citedByCount "1109" @default.
- W2052912081 countsByYear W20529120812012 @default.
- W2052912081 countsByYear W20529120812013 @default.
- W2052912081 countsByYear W20529120812014 @default.
- W2052912081 countsByYear W20529120812015 @default.
- W2052912081 countsByYear W20529120812016 @default.
- W2052912081 countsByYear W20529120812017 @default.
- W2052912081 countsByYear W20529120812018 @default.
- W2052912081 countsByYear W20529120812019 @default.
- W2052912081 countsByYear W20529120812020 @default.
- W2052912081 countsByYear W20529120812021 @default.
- W2052912081 countsByYear W20529120812022 @default.
- W2052912081 countsByYear W20529120812023 @default.
- W2052912081 crossrefType "journal-article" @default.
- W2052912081 hasAuthorship W2052912081A5003394017 @default.
- W2052912081 hasAuthorship W2052912081A5003764731 @default.
- W2052912081 hasAuthorship W2052912081A5015774072 @default.
- W2052912081 hasAuthorship W2052912081A5017173229 @default.
- W2052912081 hasAuthorship W2052912081A5040719015 @default.
- W2052912081 hasAuthorship W2052912081A5045756025 @default.
- W2052912081 hasAuthorship W2052912081A5057916930 @default.
- W2052912081 hasAuthorship W2052912081A5061302501 @default.
- W2052912081 hasAuthorship W2052912081A5078985079 @default.
- W2052912081 hasAuthorship W2052912081A5087244560 @default.
- W2052912081 hasConcept C104317684 @default.
- W2052912081 hasConcept C113842279 @default.
- W2052912081 hasConcept C143065580 @default.
- W2052912081 hasConcept C147483822 @default.
- W2052912081 hasConcept C153911025 @default.
- W2052912081 hasConcept C154317977 @default.
- W2052912081 hasConcept C202751555 @default.
- W2052912081 hasConcept C203014093 @default.
- W2052912081 hasConcept C2777658100 @default.
- W2052912081 hasConcept C501734568 @default.
- W2052912081 hasConcept C502942594 @default.