FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052912225> ?p ?o ?g. }

• W2052912225 endingPage "1117" @default.
• W2052912225 startingPage "1110" @default.
• W2052912225 abstract "Eosinophilic infiltration and peripheral blood eosinophilia in asthma require the cooperation of eosinophil-specific cytokines and chemokines and their receptors.We investigated the association of polymorphisms in CCR3 and IL5RA with asthma susceptibility or peripheral blood eosinophilia and the effects of the polymorphisms on receptor expression.Polymorphisms in CCR3 and IL5RA were identified and genotyped in 576 asthmatic patients and 180 healthy control subjects. CCR3 and IL-5 receptor alpha (IL-5R alpha) protein expression on eosinophils was measured by means of flow cytometry.Although polymorphisms in CCR3 were not associated with asthma susceptibility, the CCR3 haplotype ht2 showed a negative gene dose effect on the eosinophil count (P = .003-.009). IL5RA c.-5091G>A was weakly associated with eosinophil count. The effects of ht2 were greater when paired with IL5RA c.-5091A (P = .001-.002). CCR3 protein expression was higher on eosinophils of asthmatic patients without ht2 than in those with ht2. Asthmatic patients with the IL5RA c.-5091A allele showed higher IL-5R alpha expression than those who were homozygous for the G allele.The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed as a novel finding. These associations were more pronounced when the CCR3 polymorphisms were paired with polymorphisms in IL5RA. The protein expression levels of CCR3 and IL-5R alpha on peripheral blood eosinophils are associated with the polymorphisms on their own genes.The identification of single nucleotide polymorphisms and haplotypes of CCR3 and IL5RA might be useful in developing markers for intermediate phenotypes of eosinophil number and in designing strategies to control diseases related to hypereosinophilia." @default.
• W2052912225 created "2016-06-24" @default.
• W2052912225 creator A5001141603 @default.
• W2052912225 creator A5001326495 @default.
• W2052912225 creator A5002464127 @default.
• W2052912225 creator A5005032799 @default.
• W2052912225 creator A5016293728 @default.
• W2052912225 creator A5049049978 @default.
• W2052912225 creator A5056034329 @default.
• W2052912225 creator A5066772914 @default.
• W2052912225 creator A5070408026 @default.
• W2052912225 creator A5078144938 @default.
• W2052912225 creator A5085994157 @default.
• W2052912225 creator A5090007023 @default.
• W2052912225 date "2007-11-01" @default.
• W2052912225 modified "2023-10-18" @default.
• W2052912225 title "Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients" @default.
• W2052912225 cites W1308451 @default.
• W2052912225 cites W1495872020 @default.
• W2052912225 cites W1512518486 @default.
• W2052912225 cites W1533974518 @default.
• W2052912225 cites W1603787155 @default.
• W2052912225 cites W1826574233 @default.
• W2052912225 cites W1963846273 @default.
• W2052912225 cites W1967432661 @default.
• W2052912225 cites W1970363166 @default.
• W2052912225 cites W1971569966 @default.
• W2052912225 cites W1982140654 @default.
• W2052912225 cites W1985411605 @default.
• W2052912225 cites W1986420324 @default.
• W2052912225 cites W1992987846 @default.
• W2052912225 cites W1999641867 @default.
• W2052912225 cites W2005884316 @default.
• W2052912225 cites W2019433240 @default.
• W2052912225 cites W2022765693 @default.
• W2052912225 cites W2025797490 @default.
• W2052912225 cites W2030705868 @default.
• W2052912225 cites W2031628019 @default.
• W2052912225 cites W2046062863 @default.
• W2052912225 cites W2052140619 @default.
• W2052912225 cites W2058211118 @default.
• W2052912225 cites W2060088029 @default.
• W2052912225 cites W2075495557 @default.
• W2052912225 cites W2094584789 @default.
• W2052912225 cites W2095784197 @default.
• W2052912225 cites W2110755408 @default.
• W2052912225 cites W2128413639 @default.
• W2052912225 cites W2144165078 @default.
• W2052912225 cites W2148112198 @default.
• W2052912225 cites W2148396162 @default.
• W2052912225 cites W2161335440 @default.
• W2052912225 cites W2165754227 @default.
• W2052912225 cites W2171838005 @default.
• W2052912225 cites W2312870247 @default.
• W2052912225 cites W4245181308 @default.
• W2052912225 doi "https://doi.org/10.1016/j.jaci.2007.08.041" @default.
• W2052912225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17983872" @default.
• W2052912225 hasPublicationYear "2007" @default.
• W2052912225 type Work @default.
• W2052912225 sameAs 2052912225 @default.
• W2052912225 citedByCount "32" @default.
• W2052912225 countsByYear W20529122252012 @default.
• W2052912225 countsByYear W20529122252013 @default.
• W2052912225 countsByYear W20529122252014 @default.
• W2052912225 countsByYear W20529122252015 @default.
• W2052912225 countsByYear W20529122252017 @default.
• W2052912225 countsByYear W20529122252022 @default.
• W2052912225 crossrefType "journal-article" @default.
• W2052912225 hasAuthorship W2052912225A5001141603 @default.
• W2052912225 hasAuthorship W2052912225A5001326495 @default.
• W2052912225 hasAuthorship W2052912225A5002464127 @default.
• W2052912225 hasAuthorship W2052912225A5005032799 @default.
• W2052912225 hasAuthorship W2052912225A5016293728 @default.
• W2052912225 hasAuthorship W2052912225A5049049978 @default.
• W2052912225 hasAuthorship W2052912225A5056034329 @default.
• W2052912225 hasAuthorship W2052912225A5066772914 @default.
• W2052912225 hasAuthorship W2052912225A5070408026 @default.
• W2052912225 hasAuthorship W2052912225A5078144938 @default.
• W2052912225 hasAuthorship W2052912225A5085994157 @default.
• W2052912225 hasAuthorship W2052912225A5090007023 @default.
• W2052912225 hasConcept C104317684 @default.
• W2052912225 hasConcept C12823836 @default.
• W2052912225 hasConcept C128879288 @default.
• W2052912225 hasConcept C13373296 @default.
• W2052912225 hasConcept C135763542 @default.
• W2052912225 hasConcept C1423137 @default.
• W2052912225 hasConcept C153209595 @default.
• W2052912225 hasConcept C180754005 @default.
• W2052912225 hasConcept C197754878 @default.
• W2052912225 hasConcept C203014093 @default.
• W2052912225 hasConcept C2776042228 @default.
• W2052912225 hasConcept C2776914184 @default.
• W2052912225 hasConcept C2777037409 @default.
• W2052912225 hasConcept C2777129736 @default.
• W2052912225 hasConcept C54355233 @default.
• W2052912225 hasConcept C71924100 @default.
• W2052912225 hasConcept C86803240 @default.
• W2052912225 hasConcept C88675164 @default.

• next