Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052912275> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2052912275 abstract "INSULIN-LIKE GROWTH factor (IGF-l), a potent mitogen for breast cancer cells, has been implicated in the promotional steps of breast carcinogenesis [I]. We have recently shown that the administration of the synthetic retinoid, fenretinide (N(4-hydroxyphenyl)retinamide, 4-HPR), induces a significant decline in circulating levels of IGF-1 in breast cancer patients, which was more pronounced in younger women [2]. It is possible that the decrease of available IGF-1 in plasma might represent at least one of the mechanisms through which the retinoid interferes with the carcinogenic process. This study augments our previous work in that it endeavours to investigate the effects of plasma concentrations of 4-HPR and of its major metabolite N-(4-methoxyphenyl)retinamide (CMPR) on plasma IGF- 1. The 20 stage I (T,.,N,) breast cancer patients enrolled in the study were part of a large randornised trial of contralateral breast cancer chemoprevention with 4-HPR [3]. All patients had been randomised to receive 4-HPR (R.W. Johnson Pharmaceutical Institute, Springhouse, Pennsylvania, U.S.A.) 200 mg daily, orally for 5 years with a monthly 3-day drug holiday. Median age was 53.5 years (range 39-67) and mean body mass index (BMI), expressed as weight (kg) divided by squared height (m2), was 24.32 ? 0.6. Sixteen patients were postmenopausal and 4 premenopausal. IGF-1 levels were measured by radioimmunoassay on plasma obtained at randomisation and after a mean interval of 11 & 0.6 months, as previously described [2]. At baseline, plasma IGF-1 levels (mean + S.E.) were 154.8 + 11.4 rig/ml and decreased to 132.8 2 8.7 nglml after treatment (P=O.O06, Student t-test). Plasma levels of 4-HPR and 4-MPR were determined by highperformance liquid chromatography (HPLC), on blood samples obtained after a median time on treatment of 32 months (range U5), as previously described [4]. Since plasma levels of the drug and the metabolite have been shown to be stable during" @default.
- W2052912275 created "2016-06-24" @default.
- W2052912275 creator A5008991388 @default.
- W2052912275 creator A5012612478 @default.
- W2052912275 creator A5021075985 @default.
- W2052912275 creator A5045210324 @default.
- W2052912275 creator A5075772633 @default.
- W2052912275 date "1995-01-01" @default.
- W2052912275 modified "2023-10-18" @default.
- W2052912275 title "The metabolite N-4-methoxyphenylretinamide is a major determinant of fenretinide induced decline of plasma insulin-like growth factor-1" @default.
- W2052912275 cites W1948079440 @default.
- W2052912275 cites W2038901680 @default.
- W2052912275 cites W2103848112 @default.
- W2052912275 cites W2148077102 @default.
- W2052912275 cites W2157226695 @default.
- W2052912275 cites W2188758580 @default.
- W2052912275 cites W2264281898 @default.
- W2052912275 cites W36364033 @default.
- W2052912275 doi "https://doi.org/10.1016/0959-8049(94)00524-9" @default.
- W2052912275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7786612" @default.
- W2052912275 hasPublicationYear "1995" @default.
- W2052912275 type Work @default.
- W2052912275 sameAs 2052912275 @default.
- W2052912275 citedByCount "4" @default.
- W2052912275 crossrefType "journal-article" @default.
- W2052912275 hasAuthorship W2052912275A5008991388 @default.
- W2052912275 hasAuthorship W2052912275A5012612478 @default.
- W2052912275 hasAuthorship W2052912275A5021075985 @default.
- W2052912275 hasAuthorship W2052912275A5045210324 @default.
- W2052912275 hasAuthorship W2052912275A5075772633 @default.
- W2052912275 hasConcept C104317684 @default.
- W2052912275 hasConcept C121608353 @default.
- W2052912275 hasConcept C126322002 @default.
- W2052912275 hasConcept C134018914 @default.
- W2052912275 hasConcept C143998085 @default.
- W2052912275 hasConcept C170493617 @default.
- W2052912275 hasConcept C176685330 @default.
- W2052912275 hasConcept C185592680 @default.
- W2052912275 hasConcept C2775954498 @default.
- W2052912275 hasConcept C2775960820 @default.
- W2052912275 hasConcept C2777477808 @default.
- W2052912275 hasConcept C2779306644 @default.
- W2052912275 hasConcept C2780221984 @default.
- W2052912275 hasConcept C2780533455 @default.
- W2052912275 hasConcept C2780689927 @default.
- W2052912275 hasConcept C2781121885 @default.
- W2052912275 hasConcept C530470458 @default.
- W2052912275 hasConcept C55493867 @default.
- W2052912275 hasConcept C71924100 @default.
- W2052912275 hasConceptScore W2052912275C104317684 @default.
- W2052912275 hasConceptScore W2052912275C121608353 @default.
- W2052912275 hasConceptScore W2052912275C126322002 @default.
- W2052912275 hasConceptScore W2052912275C134018914 @default.
- W2052912275 hasConceptScore W2052912275C143998085 @default.
- W2052912275 hasConceptScore W2052912275C170493617 @default.
- W2052912275 hasConceptScore W2052912275C176685330 @default.
- W2052912275 hasConceptScore W2052912275C185592680 @default.
- W2052912275 hasConceptScore W2052912275C2775954498 @default.
- W2052912275 hasConceptScore W2052912275C2775960820 @default.
- W2052912275 hasConceptScore W2052912275C2777477808 @default.
- W2052912275 hasConceptScore W2052912275C2779306644 @default.
- W2052912275 hasConceptScore W2052912275C2780221984 @default.
- W2052912275 hasConceptScore W2052912275C2780533455 @default.
- W2052912275 hasConceptScore W2052912275C2780689927 @default.
- W2052912275 hasConceptScore W2052912275C2781121885 @default.
- W2052912275 hasConceptScore W2052912275C530470458 @default.
- W2052912275 hasConceptScore W2052912275C55493867 @default.
- W2052912275 hasConceptScore W2052912275C71924100 @default.
- W2052912275 hasLocation W20529122751 @default.
- W2052912275 hasLocation W20529122752 @default.
- W2052912275 hasOpenAccess W2052912275 @default.
- W2052912275 hasPrimaryLocation W20529122751 @default.
- W2052912275 hasRelatedWork W1997012825 @default.
- W2052912275 hasRelatedWork W2012394330 @default.
- W2052912275 hasRelatedWork W2038000824 @default.
- W2052912275 hasRelatedWork W2087751406 @default.
- W2052912275 hasRelatedWork W2089518257 @default.
- W2052912275 hasRelatedWork W2107322230 @default.
- W2052912275 hasRelatedWork W2118947223 @default.
- W2052912275 hasRelatedWork W2156844778 @default.
- W2052912275 hasRelatedWork W2415839524 @default.
- W2052912275 hasRelatedWork W1950451770 @default.
- W2052912275 isParatext "false" @default.
- W2052912275 isRetracted "false" @default.
- W2052912275 magId "2052912275" @default.
- W2052912275 workType "article" @default.