FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052914897> ?p ?o ?g. }

• W2052914897 endingPage "36" @default.
• W2052914897 startingPage "28" @default.
• W2052914897 abstract "Phosphorylation of serine 51 residue in the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) impairs the guanine nucleotide exchange (GNE) activity of eIF2B protein and thereby inhibits protein synthesis in mammalian systems, insects and yeast. It is not known if phosphorylation of plant eIF2 can inhibit an eIF2B-like activity. Interestingly purified wheat germ eIF2 (WG x eIF2) can exchange guanine nucleotides in vitro without the addition of any protein factor like eIF2B. It is not clear if this is due to a contaminant eIF2B-like activity associated with WG x eIF2 or because the affinity of WG x eIF2 for GDP and GTP is not markedly different. Our observations here indicate that the GNE activity of WG x eIF2 is not inhibited upon phosphorylation of the p41-42 doublet subunit in WG x eIF2 by reticulocyte eIF2alpha kinases, or in the presence of reticulocyte eIF2(alphaP) in which serine 51 residue is phosphorylated. Further, addition of WG x eIF2 reduces the inhibition in eIF2B activity, protein synthesis, and also the formation of 15S complex that occurs between reticulocyte eIF2(alphaP) and eIF2B protein in heme-deficient or poly(IC)-treated reticulocyte lysates, presumably by a mechanism of competition between wheat germ and reticulocyte eIF2 for phosphorylation. Unlike reticulocyte eIF2(alphaP), phosphorylated WG x eIF2 is unable to interact with reticulocyte eIF2B to form a 15S complex. The ability of WG x eIF2 to exchange guanine nucleotides independent of an eIF2B like protein and the inability of phosphorylated WG x eIF2 to interact with reticulocyte eIF2B suggests that WG x eIF2 is different from mammalian eIF2 and these differences may have occurred in evolution probably due to some changes in the amino acid sequences around the phosphorylation site in eIF2alpha." @default.
• W2052914897 created "2016-06-24" @default.
• W2052914897 creator A5010199315 @default.
• W2052914897 creator A5020868594 @default.
• W2052914897 creator A5081778084 @default.
• W2052914897 date "1997-10-01" @default.
• W2052914897 modified "2023-09-23" @default.
• W2052914897 title "Wheat Germ Initiation Factor 2 (WG·eIF2) Decreases the Inhibition in Protein Synthesis and eIF2B Activity of Reticulocyte Lysates Mediated by eIF2α Phosphorylation" @default.
• W2052914897 cites W1483444054 @default.
• W2052914897 cites W1483580282 @default.
• W2052914897 cites W1488906799 @default.
• W2052914897 cites W1510227168 @default.
• W2052914897 cites W1527791774 @default.
• W2052914897 cites W1549105044 @default.
• W2052914897 cites W1550334406 @default.
• W2052914897 cites W1551930510 @default.
• W2052914897 cites W1567209145 @default.
• W2052914897 cites W1593443523 @default.
• W2052914897 cites W1596444914 @default.
• W2052914897 cites W1599263226 @default.
• W2052914897 cites W1662634831 @default.
• W2052914897 cites W1854796378 @default.
• W2052914897 cites W1968219959 @default.
• W2052914897 cites W1968727721 @default.
• W2052914897 cites W1970529107 @default.
• W2052914897 cites W1974129290 @default.
• W2052914897 cites W1978804154 @default.
• W2052914897 cites W2010946709 @default.
• W2052914897 cites W2039027504 @default.
• W2052914897 cites W2047067350 @default.
• W2052914897 cites W2047662834 @default.
• W2052914897 cites W2050614095 @default.
• W2052914897 cites W2054663877 @default.
• W2052914897 cites W2057121138 @default.
• W2052914897 cites W2067358015 @default.
• W2052914897 cites W2074548028 @default.
• W2052914897 cites W2089232394 @default.
• W2052914897 cites W2090217527 @default.
• W2052914897 cites W2097687129 @default.
• W2052914897 cites W2100837269 @default.
• W2052914897 cites W2110786863 @default.
• W2052914897 cites W2157199600 @default.
• W2052914897 cites W2165055107 @default.
• W2052914897 cites W2166661434 @default.
• W2052914897 cites W218318767 @default.
• W2052914897 cites W2465001371 @default.
• W2052914897 cites W2789462 @default.
• W2052914897 cites W4232159746 @default.
• W2052914897 cites W4234038697 @default.
• W2052914897 cites W4250599240 @default.
• W2052914897 doi "https://doi.org/10.1006/abbi.1997.0263" @default.
• W2052914897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9328281" @default.
• W2052914897 hasPublicationYear "1997" @default.
• W2052914897 type Work @default.
• W2052914897 sameAs 2052914897 @default.
• W2052914897 citedByCount "11" @default.
• W2052914897 countsByYear W20529148972012 @default.
• W2052914897 countsByYear W20529148972015 @default.
• W2052914897 countsByYear W20529148972017 @default.
• W2052914897 countsByYear W20529148972020 @default.
• W2052914897 countsByYear W20529148972022 @default.
• W2052914897 crossrefType "journal-article" @default.
• W2052914897 hasAuthorship W2052914897A5010199315 @default.
• W2052914897 hasAuthorship W2052914897A5020868594 @default.
• W2052914897 hasAuthorship W2052914897A5081778084 @default.
• W2052914897 hasConcept C104317684 @default.
• W2052914897 hasConcept C105580179 @default.
• W2052914897 hasConcept C11960822 @default.
• W2052914897 hasConcept C126619667 @default.
• W2052914897 hasConcept C149364088 @default.
• W2052914897 hasConcept C153911025 @default.
• W2052914897 hasConcept C207332259 @default.
• W2052914897 hasConcept C2778403015 @default.
• W2052914897 hasConcept C55493867 @default.
• W2052914897 hasConcept C62493599 @default.
• W2052914897 hasConcept C67705224 @default.
• W2052914897 hasConcept C86803240 @default.
• W2052914897 hasConcept C93734116 @default.
• W2052914897 hasConcept C95444343 @default.
• W2052914897 hasConcept C97154109 @default.
• W2052914897 hasConceptScore W2052914897C104317684 @default.
• W2052914897 hasConceptScore W2052914897C105580179 @default.
• W2052914897 hasConceptScore W2052914897C11960822 @default.
• W2052914897 hasConceptScore W2052914897C126619667 @default.
• W2052914897 hasConceptScore W2052914897C149364088 @default.
• W2052914897 hasConceptScore W2052914897C153911025 @default.
• W2052914897 hasConceptScore W2052914897C207332259 @default.
• W2052914897 hasConceptScore W2052914897C2778403015 @default.
• W2052914897 hasConceptScore W2052914897C55493867 @default.
• W2052914897 hasConceptScore W2052914897C62493599 @default.
• W2052914897 hasConceptScore W2052914897C67705224 @default.
• W2052914897 hasConceptScore W2052914897C86803240 @default.
• W2052914897 hasConceptScore W2052914897C93734116 @default.
• W2052914897 hasConceptScore W2052914897C95444343 @default.
• W2052914897 hasConceptScore W2052914897C97154109 @default.
• W2052914897 hasIssue "1" @default.
• W2052914897 hasLocation W20529148971 @default.
• W2052914897 hasLocation W20529148972 @default.

• next