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- W2052916493 endingPage "161" @default.
- W2052916493 startingPage "135" @default.
- W2052916493 abstract "Delivery of 5-aminosalicylic acid to the colon by sulphasalazine, other azo-bonded compounds and controlled-release preparations is introduced in the context of metabolism by epithelial cells and therapeutic efficacy in ulcerative colitis. Potential modes of action are then reviewed, including actions on luminal bacteria, epithelial cell surface receptors, cellular events (such as nitric oxide release or butyrate oxidation), electrolyte transport and epithelial permeability. Evidence for an influence of salicylates on circulating and lamina propria inflammatory cells is presented, as well as actions on adhesion molecules, chemotactic peptides and inflammatory mediators, such as eicosanoids, platelet-activating factor, cytokines or reactive oxygen metabolites. The precise mechanism will remain uncertain as long as the aetiology of ulcerative colitis is unknown, but a pluripotential mode of action of salicylates is an advantage when influencing the network of events that constitute chronic inflammation." @default.
- W2052916493 created "2016-06-24" @default.
- W2052916493 creator A5056474210 @default.
- W2052916493 creator A5064989585 @default.
- W2052916493 date "1994-01-01" @default.
- W2052916493 modified "2023-09-23" @default.
- W2052916493 title "Salicylates for ulcerative colitis—their mode of action" @default.
- W2052916493 cites W1012217983 @default.
- W2052916493 cites W110719922 @default.
- W2052916493 cites W12972203 @default.
- W2052916493 cites W1497617769 @default.
- W2052916493 cites W1505729347 @default.
- W2052916493 cites W1512772692 @default.
- W2052916493 cites W1531938298 @default.
- W2052916493 cites W1534782991 @default.
- W2052916493 cites W1540721474 @default.
- W2052916493 cites W1541759032 @default.
- W2052916493 cites W1566382259 @default.
- W2052916493 cites W1569341848 @default.
- W2052916493 cites W1587708141 @default.
- W2052916493 cites W1590277677 @default.
- W2052916493 cites W1602033104 @default.
- W2052916493 cites W1602588405 @default.
- W2052916493 cites W1605618234 @default.
- W2052916493 cites W1612925887 @default.
- W2052916493 cites W1649485503 @default.
- W2052916493 cites W1668613481 @default.
- W2052916493 cites W1687166873 @default.
- W2052916493 cites W1727714355 @default.
- W2052916493 cites W1737578516 @default.
- W2052916493 cites W179558799 @default.
- W2052916493 cites W1853813255 @default.
- W2052916493 cites W1869404117 @default.
- W2052916493 cites W1915729929 @default.
- W2052916493 cites W193344852 @default.
- W2052916493 cites W1964233609 @default.
- W2052916493 cites W1965388947 @default.
- W2052916493 cites W1973392565 @default.
- W2052916493 cites W1973924785 @default.
- W2052916493 cites W1973960461 @default.
- W2052916493 cites W1974104914 @default.
- W2052916493 cites W1974348321 @default.
- W2052916493 cites W1976147300 @default.
- W2052916493 cites W1978140559 @default.
- W2052916493 cites W1979425960 @default.
- W2052916493 cites W1981542183 @default.
- W2052916493 cites W1981655586 @default.
- W2052916493 cites W1982808632 @default.
- W2052916493 cites W1984725180 @default.
- W2052916493 cites W1985766240 @default.
- W2052916493 cites W1986844372 @default.
- W2052916493 cites W1987349056 @default.
- W2052916493 cites W1989348805 @default.
- W2052916493 cites W1989640429 @default.
- W2052916493 cites W1989701577 @default.
- W2052916493 cites W1989740133 @default.
- W2052916493 cites W1990321660 @default.
- W2052916493 cites W1991776975 @default.
- W2052916493 cites W1993481071 @default.
- W2052916493 cites W1994820590 @default.
- W2052916493 cites W1995287714 @default.
- W2052916493 cites W1997310223 @default.
- W2052916493 cites W1998652812 @default.
- W2052916493 cites W1999197985 @default.
- W2052916493 cites W2000620826 @default.
- W2052916493 cites W2000624749 @default.
- W2052916493 cites W2001164419 @default.
- W2052916493 cites W2004080797 @default.
- W2052916493 cites W2004285246 @default.
- W2052916493 cites W2006668570 @default.
- W2052916493 cites W2008160869 @default.
- W2052916493 cites W2009944327 @default.
- W2052916493 cites W2010946554 @default.
- W2052916493 cites W2013176493 @default.
- W2052916493 cites W2013620154 @default.
- W2052916493 cites W2015343744 @default.
- W2052916493 cites W2015733818 @default.
- W2052916493 cites W2018535431 @default.
- W2052916493 cites W2019441712 @default.
- W2052916493 cites W2019657479 @default.
- W2052916493 cites W2020920100 @default.
- W2052916493 cites W2022445623 @default.
- W2052916493 cites W2022703374 @default.
- W2052916493 cites W2023562747 @default.
- W2052916493 cites W2024513902 @default.
- W2052916493 cites W2025463385 @default.
- W2052916493 cites W2025761754 @default.
- W2052916493 cites W2027953426 @default.
- W2052916493 cites W2029646376 @default.
- W2052916493 cites W2032106995 @default.
- W2052916493 cites W2032299180 @default.
- W2052916493 cites W2037844521 @default.
- W2052916493 cites W2038324532 @default.
- W2052916493 cites W2039987132 @default.
- W2052916493 cites W2040179836 @default.
- W2052916493 cites W2040228465 @default.
- W2052916493 cites W2040590993 @default.
- W2052916493 cites W2042419252 @default.