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- W2052938557 abstract "The phenomena of proliferation, metaplasia, and neoplasia of the intestinal epithelium were studied in Sprague-Dawley rats, by using 1,2-dimethylhydrazine (DMH), which was injected once weekly, subcutaneously, at a dose of 30 mgm/kgm for up to 30 weeks. Degraded carrageenan (C16) was also given either in the diet (7.5 gm/kgm) or in drinking water (5% solution) alone or in combination with DMH for up to 30 weeks. Papillary adenomas, adenomatous polyps, and adenocarcinomas of various grades were observed as having been elicited by DMH. This compound, when given alone, causes the development of tumors that arise from the superficial protion of the intestinal mucosa; when given together with C16, DMH induces proliferation of the deep glandular areas. C16 alone induces transformation of the mucosal epithelium of the distal rectum into stratified squamous epithelium. The administration of C16 in the diet, in contrast to drinking water, elicits earlier changes in proliferation." @default.
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- W2052938557 date "1975-12-01" @default.
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- W2052938557 title "Intestinal carcinogenesis in rats using 1,2-dimethylhydrazine with or without degraded carrageenan" @default.
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- W2052938557 doi "https://doi.org/10.1016/0014-4800(75)90032-5" @default.
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