FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052938595> ?p ?o ?g. }

• W2052938595 abstract "To assess whether it is clinically relevant to classify siblings of children with recent-onset type 1 diabetes mellitus (T1DM) into various stages of preclinical diabetes, and to compare the risk of developing clinical disease and the time to diagnosis between these stages.From a total of 801 families taking part in the Childhood Diabetes in Finland Study, 758 initially unaffected siblings were graded into four stages of preclinical T1DM based on the number of disease-associated autoantibodies detectable close to the time of diagnosis in the index case: no (no antibodies), early (one antibody specificity), advanced (two antibodies), and late prediabetes (more than three antibodies). Another classification system, used with 712 siblings, was based on a combination of the number of antibodies and the first-phase insulin response (FPIR) to intravenous glucose: no (no antibodies), early (one antibody specificity, normal FPIR), advanced (two or more antibodies, normal FPIR), and late prediabetes (one or more antibodies, reduced FPIR).Six out of 661 siblings who initially presented no signs of prediabetes (0.9%; 95% confidence interval [CI], 0.3%-2.0%) progressed to clinical T1DM. Based on the first set of criteria, 3 out of 49 individuals (6.1%; CI, 1.3%-16. 9%; odds ratio [OR], 7.1; CI, 1.7-29.4) from the early prediabetes category, 3 out of 13 with advanced prediabetes (23.1%; CI, 5.0%-53. 8%; OR, 32.8; CI, 7.2-150), and 23 out of 35 with late prediabetes (65.7%; CI, 47.8%-80.9%; OR, 209; CI, 72.2-607) presented with clinical signs of T1DM. According to the second set of criteria 1 out of 15 siblings with early prediabetes (6.7%; CI, 0.2%-32.0%; OR, 7.8; CI, 0.9-69.1), 6 out of 23 with advanced prediabetes (26.1%; CI, 10.2%-48.4%; OR, 38.5; CI, 11.3-132), and 12 out of 13 with late prediabetes (92.3%; CI, 64.0%-99.8%; OR, 1310; CI, 146-11 737) presented with clinical signs of T1DM. The time to diagnosis was significantly shorter in those with late prediabetes initially than in those with no signs of prediabetes.Our observations indicate that it is possible to grade siblings of children with newly diagnosed T1DM into categories with significant differences in the subsequent risk of clinical T1DM and time to diagnosis. Such a classification will become clinically relevant as soon as effective measures are available for preventing or delaying the manifestation of overt T1DM.autoantibodies, classification, prospective, first-phase insulin response." @default.
• W2052938595 created "2016-06-24" @default.
• W2052938595 creator A5000141478 @default.
• W2052938595 creator A5012285089 @default.
• W2052938595 creator A5035162132 @default.
• W2052938595 creator A5036717183 @default.
• W2052938595 creator A5057711139 @default.
• W2052938595 date "1999-10-01" @default.
• W2052938595 modified "2023-09-27" @default.
• W2052938595 title "Staging of Preclinical Type 1 Diabetes in Siblings of Affected Children" @default.
• W2052938595 cites W1972966081 @default.
• W2052938595 cites W1976059723 @default.
• W2052938595 cites W2015450984 @default.
• W2052938595 cites W2019972832 @default.
• W2052938595 cites W2026889435 @default.
• W2052938595 cites W2060618131 @default.
• W2052938595 cites W2070972996 @default.
• W2052938595 cites W2074737418 @default.
• W2052938595 cites W2074845177 @default.
• W2052938595 cites W2078073869 @default.
• W2052938595 cites W2084265620 @default.
• W2052938595 cites W2090123211 @default.
• W2052938595 cites W2092377833 @default.
• W2052938595 cites W2104258246 @default.
• W2052938595 cites W2110948955 @default.
• W2052938595 cites W2111625815 @default.
• W2052938595 cites W2120816431 @default.
• W2052938595 cites W2143450422 @default.
• W2052938595 cites W2152634588 @default.
• W2052938595 cites W2154652130 @default.
• W2052938595 cites W2326351105 @default.
• W2052938595 cites W2326904657 @default.
• W2052938595 cites W2334639754 @default.
• W2052938595 cites W2414935058 @default.
• W2052938595 cites W73012796 @default.
• W2052938595 doi "https://doi.org/10.1542/peds.104.4.925" @default.
• W2052938595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10506236" @default.
• W2052938595 hasPublicationYear "1999" @default.
• W2052938595 type Work @default.
• W2052938595 sameAs 2052938595 @default.
• W2052938595 citedByCount "25" @default.
• W2052938595 countsByYear W20529385952016 @default.
• W2052938595 countsByYear W20529385952018 @default.
• W2052938595 countsByYear W20529385952021 @default.
• W2052938595 crossrefType "journal-article" @default.
• W2052938595 hasAuthorship W2052938595A5000141478 @default.
• W2052938595 hasAuthorship W2052938595A5012285089 @default.
• W2052938595 hasAuthorship W2052938595A5035162132 @default.
• W2052938595 hasAuthorship W2052938595A5036717183 @default.
• W2052938595 hasAuthorship W2052938595A5057711139 @default.
• W2052938595 hasConcept C126322002 @default.
• W2052938595 hasConcept C134018914 @default.
• W2052938595 hasConcept C138496976 @default.
• W2052938595 hasConcept C156957248 @default.
• W2052938595 hasConcept C15744967 @default.
• W2052938595 hasConcept C159654299 @default.
• W2052938595 hasConcept C163764329 @default.
• W2052938595 hasConcept C187212893 @default.
• W2052938595 hasConcept C203014093 @default.
• W2052938595 hasConcept C2776194465 @default.
• W2052938595 hasConcept C2777180221 @default.
• W2052938595 hasConcept C2779134260 @default.
• W2052938595 hasConcept C2779668308 @default.
• W2052938595 hasConcept C2781232474 @default.
• W2052938595 hasConcept C44249647 @default.
• W2052938595 hasConcept C555293320 @default.
• W2052938595 hasConcept C71924100 @default.
• W2052938595 hasConceptScore W2052938595C126322002 @default.
• W2052938595 hasConceptScore W2052938595C134018914 @default.
• W2052938595 hasConceptScore W2052938595C138496976 @default.
• W2052938595 hasConceptScore W2052938595C156957248 @default.
• W2052938595 hasConceptScore W2052938595C15744967 @default.
• W2052938595 hasConceptScore W2052938595C159654299 @default.
• W2052938595 hasConceptScore W2052938595C163764329 @default.
• W2052938595 hasConceptScore W2052938595C187212893 @default.
• W2052938595 hasConceptScore W2052938595C203014093 @default.
• W2052938595 hasConceptScore W2052938595C2776194465 @default.
• W2052938595 hasConceptScore W2052938595C2777180221 @default.
• W2052938595 hasConceptScore W2052938595C2779134260 @default.
• W2052938595 hasConceptScore W2052938595C2779668308 @default.
• W2052938595 hasConceptScore W2052938595C2781232474 @default.
• W2052938595 hasConceptScore W2052938595C44249647 @default.
• W2052938595 hasConceptScore W2052938595C555293320 @default.
• W2052938595 hasConceptScore W2052938595C71924100 @default.
• W2052938595 hasLocation W20529385951 @default.
• W2052938595 hasLocation W20529385952 @default.
• W2052938595 hasOpenAccess W2052938595 @default.
• W2052938595 hasPrimaryLocation W20529385951 @default.
• W2052938595 hasRelatedWork W1981009470 @default.
• W2052938595 hasRelatedWork W1986262724 @default.
• W2052938595 hasRelatedWork W2001532213 @default.
• W2052938595 hasRelatedWork W2002434849 @default.
• W2052938595 hasRelatedWork W2019930733 @default.
• W2052938595 hasRelatedWork W2019972832 @default.
• W2052938595 hasRelatedWork W2020054216 @default.
• W2052938595 hasRelatedWork W2037118258 @default.
• W2052938595 hasRelatedWork W2050664844 @default.
• W2052938595 hasRelatedWork W2060618131 @default.
• W2052938595 hasRelatedWork W2070972996 @default.
• W2052938595 hasRelatedWork W2092377833 @default.

• next