Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052941509> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2052941509 endingPage "265" @default.
- W2052941509 startingPage "257" @default.
- W2052941509 abstract "Malignant hyperthermia (MH) is a genetic disease in man and other animal species that predisposes to a catastrophic hypermetabolic syndrome that is triggered by certain anesthetic agents. A working hypothesis is that a defect in regulation of muscle cell calcium is the primary mechanism that initiates the MH syndrome. This paper reviews the evidence for a defect in muscle cell calcium as regulated by the sarcoplasmic reticulum membrane system. Skeletal muscle biopsied from MH man, pigs and dogs has abnormal in vitro contracture response to halothane and caffeine and these responses can be altered by lowering calcium content of the bathing solution and/or the muscle. Measurements of MH muscle cell Ca2+ by Ca2+-specific microelectrodes in vivo and fura-2 in vitro have demonstrated abnormal Ca2+ levels in resting and in caffeine-stimulated states. The SR membrane system is the primary calcium regulating organelle in skeletal muscle and a likely site for the defect in MH muscle. Two Ca2+ regulating functions of the SR have been explored in SR isolated from MH muscle. An abnormality of the 100K Ca2+-ATPase protein that functions to transport Ca2+ from myoplasm to inside the SR does not appear to be responsible for MH. The most probable defective site in the SR appears to be Ca2+ release channels and a Ca2+-induced Ca2+ release pathway has been shown to be abnormal in SR from MH human and pig muscle." @default.
- W2052941509 created "2016-06-24" @default.
- W2052941509 creator A5089886190 @default.
- W2052941509 date "1988-10-01" @default.
- W2052941509 modified "2023-10-18" @default.
- W2052941509 title "SR Function in malignant hyperthermia" @default.
- W2052941509 cites W1483833346 @default.
- W2052941509 cites W1559841125 @default.
- W2052941509 cites W1563253655 @default.
- W2052941509 cites W1964166811 @default.
- W2052941509 cites W1981759316 @default.
- W2052941509 cites W1993407392 @default.
- W2052941509 cites W1995677296 @default.
- W2052941509 cites W2004472849 @default.
- W2052941509 cites W2019469419 @default.
- W2052941509 cites W2024406368 @default.
- W2052941509 cites W2029624664 @default.
- W2052941509 cites W2030447016 @default.
- W2052941509 cites W2052407942 @default.
- W2052941509 cites W2052739933 @default.
- W2052941509 cites W2054909191 @default.
- W2052941509 cites W2059836657 @default.
- W2052941509 cites W2065663971 @default.
- W2052941509 cites W2073771332 @default.
- W2052941509 cites W2085139421 @default.
- W2052941509 cites W2095152173 @default.
- W2052941509 cites W2128903096 @default.
- W2052941509 cites W2138310843 @default.
- W2052941509 cites W2140004926 @default.
- W2052941509 cites W2160430268 @default.
- W2052941509 cites W2766295444 @default.
- W2052941509 cites W4235182483 @default.
- W2052941509 cites W4247625354 @default.
- W2052941509 doi "https://doi.org/10.1016/0143-4160(88)90006-1" @default.
- W2052941509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3066491" @default.
- W2052941509 hasPublicationYear "1988" @default.
- W2052941509 type Work @default.
- W2052941509 sameAs 2052941509 @default.
- W2052941509 citedByCount "29" @default.
- W2052941509 countsByYear W20529415092022 @default.
- W2052941509 crossrefType "journal-article" @default.
- W2052941509 hasAuthorship W2052941509A5089886190 @default.
- W2052941509 hasConcept C126322002 @default.
- W2052941509 hasConcept C134018914 @default.
- W2052941509 hasConcept C142724271 @default.
- W2052941509 hasConcept C158617107 @default.
- W2052941509 hasConcept C178790620 @default.
- W2052941509 hasConcept C185592680 @default.
- W2052941509 hasConcept C207200792 @default.
- W2052941509 hasConcept C2776932660 @default.
- W2052941509 hasConcept C2778500429 @default.
- W2052941509 hasConcept C2778575482 @default.
- W2052941509 hasConcept C2779959927 @default.
- W2052941509 hasConcept C2909765735 @default.
- W2052941509 hasConcept C519063684 @default.
- W2052941509 hasConcept C55493867 @default.
- W2052941509 hasConcept C71924100 @default.
- W2052941509 hasConcept C86803240 @default.
- W2052941509 hasConcept C87975464 @default.
- W2052941509 hasConcept C95444343 @default.
- W2052941509 hasConceptScore W2052941509C126322002 @default.
- W2052941509 hasConceptScore W2052941509C134018914 @default.
- W2052941509 hasConceptScore W2052941509C142724271 @default.
- W2052941509 hasConceptScore W2052941509C158617107 @default.
- W2052941509 hasConceptScore W2052941509C178790620 @default.
- W2052941509 hasConceptScore W2052941509C185592680 @default.
- W2052941509 hasConceptScore W2052941509C207200792 @default.
- W2052941509 hasConceptScore W2052941509C2776932660 @default.
- W2052941509 hasConceptScore W2052941509C2778500429 @default.
- W2052941509 hasConceptScore W2052941509C2778575482 @default.
- W2052941509 hasConceptScore W2052941509C2779959927 @default.
- W2052941509 hasConceptScore W2052941509C2909765735 @default.
- W2052941509 hasConceptScore W2052941509C519063684 @default.
- W2052941509 hasConceptScore W2052941509C55493867 @default.
- W2052941509 hasConceptScore W2052941509C71924100 @default.
- W2052941509 hasConceptScore W2052941509C86803240 @default.
- W2052941509 hasConceptScore W2052941509C87975464 @default.
- W2052941509 hasConceptScore W2052941509C95444343 @default.
- W2052941509 hasIssue "5-6" @default.
- W2052941509 hasLocation W20529415091 @default.
- W2052941509 hasLocation W20529415092 @default.
- W2052941509 hasOpenAccess W2052941509 @default.
- W2052941509 hasPrimaryLocation W20529415091 @default.
- W2052941509 hasRelatedWork W1964127633 @default.
- W2052941509 hasRelatedWork W1974583040 @default.
- W2052941509 hasRelatedWork W2017703961 @default.
- W2052941509 hasRelatedWork W2040086427 @default.
- W2052941509 hasRelatedWork W2064236298 @default.
- W2052941509 hasRelatedWork W2084131895 @default.
- W2052941509 hasRelatedWork W2104605768 @default.
- W2052941509 hasRelatedWork W2153739000 @default.
- W2052941509 hasRelatedWork W2413553882 @default.
- W2052941509 hasRelatedWork W4243403002 @default.
- W2052941509 hasVolume "9" @default.
- W2052941509 isParatext "false" @default.
- W2052941509 isRetracted "false" @default.
- W2052941509 magId "2052941509" @default.
- W2052941509 workType "article" @default.