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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052958432> ?p ?o ?g. }

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• W2052958432 abstract "We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor α (RXRα) and its phosphorylated form (p-RXRα) in HL-60 and HL-60R cells. 9-cis RA reduced both RXRα and p-RXRα in HL-60 cells, but did neither in HL-60R cells. However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXRα and RXRα proteins all markedly decreased. Moreover, the combination of those agents induced apoptosis in HL-60R cells. Phosphorylation of RXRα might be associated with RA-resistance in HL-60R cells." @default.
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• W2052958432 date "2008-06-01" @default.
• W2052958432 modified "2023-09-27" @default.
• W2052958432 title "Retinoid X receptor α is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells" @default.
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• W2052958432 doi "https://doi.org/10.1016/j.leukres.2007.11.005" @default.
• W2052958432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18082883" @default.
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