FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052964034> ?p ?o ?g. }

• W2052964034 endingPage "125" @default.
• W2052964034 startingPage "113" @default.
• W2052964034 abstract "Cytosolic phospholipase A(2)-alpha (cPLA(2)) plays an important role in the release of arachidonic acid and in cell injury. Activation of cPLA(2) is dependent on a rise in cytosolic Ca(2+) concentration, membrane association via the Ca(2+)-dependent lipid binding (CaLB) domain, and phosphorylation. This study addresses the activation of cPLA(2) via potential association with membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)), including the role of a pleckstrin homology (PH)-like region of cPLA(2) (amino acids 263-354). In cells incubated with complement, phorbol myristate acetate+the Ca(2+) ionophore, A23187, or epidermal growth factor+A23187, expression of the PH domain of phospholipase C-delta1 (which sequesters membrane PIP(2)) attenuated cPLA(2) activity. Stimulated cPLA(2) activity was also attenuated by the expression of cPLA(2) 135-366, or cPLA(2) 2-366, and expression of a PIP(2)-specific 5'-phosphatase. However, in a yeast-based assay that tests the ability of proteins to bind to membrane lipids, including PIP(2), with high affinity, only cPLA(2) 1-200 (CaLB domain) was able to interact with membrane lipids, whereas cPLA(2)s 135-366, 2-366, 201-648, and 1-648 were unable to do so. Therefore, cPLA(2) activity can be modulated by sequestration or depletion of cellular PIP(2), although the interaction of cPLA(2) with membrane PIP(2) appears to be indirect, or of weak affinity." @default.
• W2052964034 created "2016-06-24" @default.
• W2052964034 creator A5008609448 @default.
• W2052964034 creator A5024023421 @default.
• W2052964034 creator A5042256043 @default.
• W2052964034 creator A5043984170 @default.
• W2052964034 creator A5057779986 @default.
• W2052964034 date "2006-12-01" @default.
• W2052964034 modified "2023-09-27" @default.
• W2052964034 title "Role of phosphatidylinositol 4,5-bisphosphate in the activation of cytosolic phospholipase A2-α" @default.
• W2052964034 cites W1975287199 @default.
• W2052964034 cites W1980507477 @default.
• W2052964034 cites W1982142716 @default.
• W2052964034 cites W1998322637 @default.
• W2052964034 cites W1998702692 @default.
• W2052964034 cites W2010104107 @default.
• W2052964034 cites W2016645421 @default.
• W2052964034 cites W2019774786 @default.
• W2052964034 cites W2039376197 @default.
• W2052964034 cites W2040470620 @default.
• W2052964034 cites W2043538721 @default.
• W2052964034 cites W2043634254 @default.
• W2052964034 cites W2055761277 @default.
• W2052964034 cites W2055761513 @default.
• W2052964034 cites W2056388697 @default.
• W2052964034 cites W2062449029 @default.
• W2052964034 cites W2080037386 @default.
• W2052964034 cites W2087449196 @default.
• W2052964034 cites W2088927230 @default.
• W2052964034 cites W2091701502 @default.
• W2052964034 cites W2100333441 @default.
• W2052964034 cites W2110894800 @default.
• W2052964034 cites W2118747178 @default.
• W2052964034 cites W2119060894 @default.
• W2052964034 cites W2125215711 @default.
• W2052964034 cites W2128303012 @default.
• W2052964034 cites W2129595885 @default.
• W2052964034 cites W2132305492 @default.
• W2052964034 cites W2141206157 @default.
• W2052964034 cites W2145945997 @default.
• W2052964034 cites W2155511306 @default.
• W2052964034 cites W2156827480 @default.
• W2052964034 cites W2169082359 @default.
• W2052964034 cites W2304452880 @default.
• W2052964034 cites W4247567611 @default.
• W2052964034 cites W4251893551 @default.
• W2052964034 doi "https://doi.org/10.1016/j.prostaglandins.2006.08.004" @default.
• W2052964034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17085320" @default.
• W2052964034 hasPublicationYear "2006" @default.
• W2052964034 type Work @default.
• W2052964034 sameAs 2052964034 @default.
• W2052964034 citedByCount "6" @default.
• W2052964034 countsByYear W20529640342013 @default.
• W2052964034 countsByYear W20529640342015 @default.
• W2052964034 crossrefType "journal-article" @default.
• W2052964034 hasAuthorship W2052964034A5008609448 @default.
• W2052964034 hasAuthorship W2052964034A5024023421 @default.
• W2052964034 hasAuthorship W2052964034A5042256043 @default.
• W2052964034 hasAuthorship W2052964034A5043984170 @default.
• W2052964034 hasAuthorship W2052964034A5057779986 @default.
• W2052964034 hasConcept C11960822 @default.
• W2052964034 hasConcept C12927208 @default.
• W2052964034 hasConcept C143840085 @default.
• W2052964034 hasConcept C181199279 @default.
• W2052964034 hasConcept C185592680 @default.
• W2052964034 hasConcept C2776551241 @default.
• W2052964034 hasConcept C2776888444 @default.
• W2052964034 hasConcept C2777853560 @default.
• W2052964034 hasConcept C2778078955 @default.
• W2052964034 hasConcept C2780610907 @default.
• W2052964034 hasConcept C41625074 @default.
• W2052964034 hasConcept C49658373 @default.
• W2052964034 hasConcept C55493867 @default.
• W2052964034 hasConcept C86803240 @default.
• W2052964034 hasConcept C95444343 @default.
• W2052964034 hasConcept C98539663 @default.
• W2052964034 hasConceptScore W2052964034C11960822 @default.
• W2052964034 hasConceptScore W2052964034C12927208 @default.
• W2052964034 hasConceptScore W2052964034C143840085 @default.
• W2052964034 hasConceptScore W2052964034C181199279 @default.
• W2052964034 hasConceptScore W2052964034C185592680 @default.
• W2052964034 hasConceptScore W2052964034C2776551241 @default.
• W2052964034 hasConceptScore W2052964034C2776888444 @default.
• W2052964034 hasConceptScore W2052964034C2777853560 @default.
• W2052964034 hasConceptScore W2052964034C2778078955 @default.
• W2052964034 hasConceptScore W2052964034C2780610907 @default.
• W2052964034 hasConceptScore W2052964034C41625074 @default.
• W2052964034 hasConceptScore W2052964034C49658373 @default.
• W2052964034 hasConceptScore W2052964034C55493867 @default.
• W2052964034 hasConceptScore W2052964034C86803240 @default.
• W2052964034 hasConceptScore W2052964034C95444343 @default.
• W2052964034 hasConceptScore W2052964034C98539663 @default.
• W2052964034 hasIssue "3-4" @default.
• W2052964034 hasLocation W20529640341 @default.
• W2052964034 hasLocation W20529640342 @default.
• W2052964034 hasOpenAccess W2052964034 @default.
• W2052964034 hasPrimaryLocation W20529640341 @default.
• W2052964034 hasRelatedWork W131513067 @default.

• next