Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052965509> ?p ?o ?g. }
- W2052965509 endingPage "1365" @default.
- W2052965509 startingPage "1351" @default.
- W2052965509 abstract "Hyaluronan is a multifunctional glycosaminoglycan that forms the structural basis of the pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of three hyaluronan synthases and anchored to the cell surface by the synthase or cell surface receptors such as CD44 or RHAMM. Aggregating proteoglycans and other hyaluronan-binding proteins, contribute to the material and biological properties of the matrix and regulate cell and tissue function. The pericellular matrix plays multiple complex roles in cell adhesion/de-adhesion, and cell shape changes associated with proliferation and locomotion. Time-lapse studies show that pericellular matrix formation facilitates cell detachment and mitotic cell rounding. Hyaluronan crosslinking occurs through various proteins, such as tenascin, TSG-6, inter-alpha-trypsin inhibitor, pentraxin and TSP-1. This creates higher order levels of structured hyaluronan that may regulate inflammation and other biological processes. Microvillous or filopodial membrane protrusions are created by active hyaluronan synthesis, and form the scaffold of hyaluronan coats in certain cells. The importance of the pericellular matrix in cellular mechanotransduction and the response to mechanical strain are also discussed." @default.
- W2052965509 created "2016-06-24" @default.
- W2052965509 creator A5024772304 @default.
- W2052965509 creator A5035268339 @default.
- W2052965509 creator A5088219196 @default.
- W2052965509 creator A5088605616 @default.
- W2052965509 date "2007-11-10" @default.
- W2052965509 modified "2023-09-24" @default.
- W2052965509 title "Hyaluronan-dependent pericellular matrix☆" @default.
- W2052965509 cites W108575403 @default.
- W2052965509 cites W13942825 @default.
- W2052965509 cites W1508769459 @default.
- W2052965509 cites W1515081605 @default.
- W2052965509 cites W1526481208 @default.
- W2052965509 cites W1543809841 @default.
- W2052965509 cites W1581089490 @default.
- W2052965509 cites W1605041458 @default.
- W2052965509 cites W1690718176 @default.
- W2052965509 cites W1721891373 @default.
- W2052965509 cites W1911557575 @default.
- W2052965509 cites W1963735154 @default.
- W2052965509 cites W1964492287 @default.
- W2052965509 cites W1966422114 @default.
- W2052965509 cites W1967179462 @default.
- W2052965509 cites W1967831582 @default.
- W2052965509 cites W1969108243 @default.
- W2052965509 cites W1970405176 @default.
- W2052965509 cites W1972287753 @default.
- W2052965509 cites W1974815300 @default.
- W2052965509 cites W1976689895 @default.
- W2052965509 cites W1979402025 @default.
- W2052965509 cites W1979837737 @default.
- W2052965509 cites W1983020647 @default.
- W2052965509 cites W1990900867 @default.
- W2052965509 cites W1990917414 @default.
- W2052965509 cites W1991189072 @default.
- W2052965509 cites W1991626074 @default.
- W2052965509 cites W1992486586 @default.
- W2052965509 cites W1997180743 @default.
- W2052965509 cites W1997263313 @default.
- W2052965509 cites W1998396052 @default.
- W2052965509 cites W2000655121 @default.
- W2052965509 cites W2003726233 @default.
- W2052965509 cites W2005457203 @default.
- W2052965509 cites W2006001607 @default.
- W2052965509 cites W2006184315 @default.
- W2052965509 cites W2007381835 @default.
- W2052965509 cites W2008709628 @default.
- W2052965509 cites W2011405727 @default.
- W2052965509 cites W2013001860 @default.
- W2052965509 cites W2013472084 @default.
- W2052965509 cites W2015204889 @default.
- W2052965509 cites W2016347117 @default.
- W2052965509 cites W2016593129 @default.
- W2052965509 cites W2022812881 @default.
- W2052965509 cites W2023208535 @default.
- W2052965509 cites W2027548706 @default.
- W2052965509 cites W2029551593 @default.
- W2052965509 cites W2029575434 @default.
- W2052965509 cites W2029834185 @default.
- W2052965509 cites W2034305425 @default.
- W2052965509 cites W2036143536 @default.
- W2052965509 cites W2036672354 @default.
- W2052965509 cites W2037012329 @default.
- W2052965509 cites W2041654773 @default.
- W2052965509 cites W2044562326 @default.
- W2052965509 cites W2045856259 @default.
- W2052965509 cites W2047503754 @default.
- W2052965509 cites W2048419780 @default.
- W2052965509 cites W2048723842 @default.
- W2052965509 cites W2050333516 @default.
- W2052965509 cites W2050983302 @default.
- W2052965509 cites W2051563649 @default.
- W2052965509 cites W2057936850 @default.
- W2052965509 cites W2060474417 @default.
- W2052965509 cites W2060563559 @default.
- W2052965509 cites W2060787184 @default.
- W2052965509 cites W2061666051 @default.
- W2052965509 cites W2061814970 @default.
- W2052965509 cites W2064864417 @default.
- W2052965509 cites W2065362197 @default.
- W2052965509 cites W2066800001 @default.
- W2052965509 cites W2069280511 @default.
- W2052965509 cites W2069361749 @default.
- W2052965509 cites W2076486888 @default.
- W2052965509 cites W2079586552 @default.
- W2052965509 cites W2083931021 @default.
- W2052965509 cites W2085354713 @default.
- W2052965509 cites W2086608260 @default.
- W2052965509 cites W2087244516 @default.
- W2052965509 cites W2089753996 @default.
- W2052965509 cites W2089764248 @default.
- W2052965509 cites W2090815473 @default.
- W2052965509 cites W2093024719 @default.
- W2052965509 cites W2098274894 @default.
- W2052965509 cites W2099392253 @default.
- W2052965509 cites W2100010472 @default.
- W2052965509 cites W2103749562 @default.