FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052973105> ?p ?o ?g. }

• W2052973105 endingPage "11245" @default.
• W2052973105 startingPage "11233" @default.
• W2052973105 abstract "ABSTRACT We previously demonstrated that after vaccination of BALB/c mice with DNA encoding murine cytomegalovirus (MCMV) IE1 or M84, a similar level of protection against MCMV infection was achieved. However, the percentage of antigen-specific CD8 + T cells elicited by IE1 was higher than that by M84 as measured by intracellular cytokine staining when splenocytes were stimulated with an epitope peptide (M. Ye at al., J. Virol. 76:2100-2112, 2002). We show here that after DNA vaccination with M84, a higher percentage of M84-specific CD8 + T cells was detected when splenocytes were stimulated with J774 cells expressing full-length M84. When the defined M84 epitope 297-305 was deleted, the mutant DNA vaccine was still protective against MCMV replication and induced strong M84-specific CD8 + -T-cell responses. The M84 gene was subsequently subcloned into three fragments encoding overlapping protein fragments. When mice were immunized with each of the M84 subfragment DNAs, at least two additional protective CD8 + -T-cell epitopes were detected. In contrast to strong responses after DNA vaccination, M84-specific CD8 + -T-cell responses were poorly induced during MCMV infection. The weak M84-specific response after MCMV infection was not due to poor antigen presentation in antigen-presenting cells, since both J774 macrophages and primary peritoneal macrophages infected with MCMV in vitro were able to efficiently and constitutively present M84-specific epitopes starting at the early phase of infection. These results indicate that antigen presentation by macrophages is not sufficient for M84-specific CD8 + -T-cell responses during MCMV infection." @default.
• W2052973105 created "2016-06-24" @default.
• W2052973105 creator A5052328406 @default.
• W2052973105 creator A5053968035 @default.
• W2052973105 creator A5081577356 @default.
• W2052973105 date "2004-10-15" @default.
• W2052973105 modified "2023-09-27" @default.
• W2052973105 title "Multiple Epitopes in the Murine Cytomegalovirus Early Gene Product M84 Are Efficiently Presented in Infected Primary Macrophages and Contribute to Strong CD8 ⁺ -T-Lymphocyte Responses and Protection following DNA Immunization" @default.
• W2052973105 cites W1481563807 @default.
• W2052973105 cites W1592869743 @default.
• W2052973105 cites W1747421101 @default.
• W2052973105 cites W1770676897 @default.
• W2052973105 cites W1803095506 @default.
• W2052973105 cites W1825386773 @default.
• W2052973105 cites W1974327633 @default.
• W2052973105 cites W1980897291 @default.
• W2052973105 cites W2003273214 @default.
• W2052973105 cites W2036514162 @default.
• W2052973105 cites W2037134755 @default.
• W2052973105 cites W2047677354 @default.
• W2052973105 cites W2050529323 @default.
• W2052973105 cites W2059943231 @default.
• W2052973105 cites W2063476615 @default.
• W2052973105 cites W2085244301 @default.
• W2052973105 cites W2091956098 @default.
• W2052973105 cites W2103711709 @default.
• W2052973105 cites W2106587699 @default.
• W2052973105 cites W2108367007 @default.
• W2052973105 cites W2109856800 @default.
• W2052973105 cites W2111493896 @default.
• W2052973105 cites W2111746719 @default.
• W2052973105 cites W2124066648 @default.
• W2052973105 cites W2134912795 @default.
• W2052973105 cites W2135169564 @default.
• W2052973105 cites W2135170988 @default.
• W2052973105 cites W2137522671 @default.
• W2052973105 cites W2141056328 @default.
• W2052973105 cites W2149220820 @default.
• W2052973105 cites W2150467115 @default.
• W2052973105 cites W2160021770 @default.
• W2052973105 cites W2163925087 @default.
• W2052973105 cites W2172188624 @default.
• W2052973105 cites W2232857533 @default.
• W2052973105 cites W2294922792 @default.
• W2052973105 doi "https://doi.org/10.1128/jvi.78.20.11233-11245.2004" @default.
• W2052973105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/521820" @default.
• W2052973105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15452242" @default.
• W2052973105 hasPublicationYear "2004" @default.
• W2052973105 type Work @default.
• W2052973105 sameAs 2052973105 @default.
• W2052973105 citedByCount "14" @default.
• W2052973105 countsByYear W20529731052012 @default.
• W2052973105 countsByYear W20529731052013 @default.
• W2052973105 countsByYear W20529731052016 @default.
• W2052973105 crossrefType "journal-article" @default.
• W2052973105 hasAuthorship W2052973105A5052328406 @default.
• W2052973105 hasAuthorship W2052973105A5053968035 @default.
• W2052973105 hasAuthorship W2052973105A5081577356 @default.
• W2052973105 hasBestOaLocation W20529731051 @default.
• W2052973105 hasConcept C147483822 @default.
• W2052973105 hasConcept C153911025 @default.
• W2052973105 hasConcept C154317977 @default.
• W2052973105 hasConcept C159047783 @default.
• W2052973105 hasConcept C167508917 @default.
• W2052973105 hasConcept C167672396 @default.
• W2052973105 hasConcept C195616568 @default.
• W2052973105 hasConcept C202751555 @default.
• W2052973105 hasConcept C203014093 @default.
• W2052973105 hasConcept C2776090121 @default.
• W2052973105 hasConcept C2780801004 @default.
• W2052973105 hasConcept C54355233 @default.
• W2052973105 hasConcept C86803240 @default.
• W2052973105 hasConcept C8891405 @default.
• W2052973105 hasConceptScore W2052973105C147483822 @default.
• W2052973105 hasConceptScore W2052973105C153911025 @default.
• W2052973105 hasConceptScore W2052973105C154317977 @default.
• W2052973105 hasConceptScore W2052973105C159047783 @default.
• W2052973105 hasConceptScore W2052973105C167508917 @default.
• W2052973105 hasConceptScore W2052973105C167672396 @default.
• W2052973105 hasConceptScore W2052973105C195616568 @default.
• W2052973105 hasConceptScore W2052973105C202751555 @default.
• W2052973105 hasConceptScore W2052973105C203014093 @default.
• W2052973105 hasConceptScore W2052973105C2776090121 @default.
• W2052973105 hasConceptScore W2052973105C2780801004 @default.
• W2052973105 hasConceptScore W2052973105C54355233 @default.
• W2052973105 hasConceptScore W2052973105C86803240 @default.
• W2052973105 hasConceptScore W2052973105C8891405 @default.
• W2052973105 hasIssue "20" @default.
• W2052973105 hasLocation W20529731051 @default.
• W2052973105 hasLocation W20529731052 @default.
• W2052973105 hasLocation W20529731053 @default.
• W2052973105 hasLocation W20529731054 @default.
• W2052973105 hasOpenAccess W2052973105 @default.
• W2052973105 hasPrimaryLocation W20529731051 @default.
• W2052973105 hasRelatedWork W1485224098 @default.
• W2052973105 hasRelatedWork W2016031396 @default.
• W2052973105 hasRelatedWork W2052483994 @default.
• W2052973105 hasRelatedWork W2136815099 @default.

• next