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• W2053002359 abstract "Spider venom comprises a mixture of compounds with diverse biological activities, which are used to capture prey and defend against predators. The peptide components bind a broad range of cellular targets with high affinity and selectivity, and appear to have remarkable structural diversity. Although spider venoms have been intensively investigated over the past few decades, venomic strategies to date have generally focused on high-abundance peptides. In addition, the lack of complete spider genomes or representative cDNA libraries has presented significant limitations for researchers interested in molecular diversity and understanding the genetic mechanisms of toxin evolution. In the present study, second-generation sequencing technologies, combined with proteomic analysis, were applied to determine the diverse peptide toxins in venom of the Chinese bird spider Ornithoctonus huwena. In total, 626 toxin precursor sequences were retrieved from transcriptomic data. All toxin precursors clustered into 16 gene superfamilies, which included six novel superfamilies and six novel cysteine patterns. A surprisingly high number of hypermutations and fragment insertions/deletions were detected, which accounted for the majority of toxin gene sequences with low-level expression. These mutations contribute to the formation of diverse cysteine patterns and highly variable isoforms. Furthermore, intraspecific venom variability, in combination with variable transcripts and peptide processing, contributes to the hypervariability of toxins in venoms, and associated rapid and adaptive evolution of toxins for prey capture and defense." @default.
• W2053002359 created "2016-06-24" @default.
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• W2053002359 date "2014-01-01" @default.
• W2053002359 modified "2023-09-23" @default.
• W2053002359 title "Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena." @default.
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• W2053002359 doi "https://doi.org/10.1371/journal.pone.0100682" @default.
• W2053002359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4065081" @default.
• W2053002359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24949878" @default.
• W2053002359 hasPublicationYear "2014" @default.
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